A5076020192- Regulation of Appetite and Obesity
- Circadian rhythm and melatonin
- Birth, Development, and Health
- Nuts composition and effects
- Antioxidant Activity and Oxidative Stress
- Sleep and Wakefulness Research
- Estrogen and related hormone effects
- Coconut Research and Applications
- Hypothalamic control of reproductive hormones
- Growth Hormone and Insulin-like Growth Factors
- Parkinson's Disease Mechanisms and Treatments
- Stress Responses and Cortisol
- Biochemical Analysis and Sensing Techniques
- Nutrition, Genetics, and Disease
- Neurological disorders and treatments
- Nutritional Studies and Diet
- Restless Legs Syndrome Research
- Eating Disorders and Behaviors
- Sexual Differentiation and Disorders
- Adipose Tissue and Metabolism
- Hormonal and reproductive studies
- Muscle metabolism and nutrition
- Dementia and Cognitive Impairment Research
- Lipid metabolism and disorders
- Diet and metabolism studies
Universidade de Santiago de Compostela
2023-2024
Universidad Europea
2022-2024
Universidad Villanueva
2022-2024
Instituto de Salud Carlos III
2022-2024
Escuela Nacional de Sanidad
2020-2023
National University of Distance Education
2020-2023
Hospital de Santa Cruz
2010
Hospital de Basurto
2007
Universidad de Granada
1999-2001
Complejo Hospitalario Universitario de Granada
2000
Abstract Parkinson's disease (PD) is a neurodegenerative disorder that imposes an important burden upon the patient's caregiver. This study aims at assessing caregiver (CB) and analyzing its relationship with sociodemographic, emotional, functional factors, as well health‐related quality of life (HRQoL). The following measures were applied to 80 patients PD: Hospital Anxiety Depression Scale (HADS); EuroQoL (for HRQoL); PD‐specific (Hoehn Yahr staging SCOPA‐Motor ADL subscale). Patients'...
G protein-coupled estrogen receptor (GPER) in the amygdala and dorsal hippocampus mediates actions of estradiol on anxiety, social recognition spatial memory. In addition, GPER participates estrogenic regulation synaptic function process adult neurogenesis dentate gyrus. While distribution canonical receptors α β are well characterized, little is known about regional these brain regions whether this affected by sex or stages estrous cycle. study we performed a morphometric analysis...
Tree nuts and peanuts (henceforth, nuts) are nutrient-dense foods rich in neuroprotective components; thus, their consumption could benefit cognitive health. However, evidence to date is limited inconsistent regarding the potential benefits of for function.To prospectively evaluate association between nut 2-y changes performance older adults at decline risk.A total 6,630 participants aged 55 75 y (mean age 65.0±4.9 y, 48.4% women) with overweight/obesity metabolic syndrome completed a...
Sex steroid hormones, such as androgens and estrogens, are known to exert organizational action at perinatal periods activational effects during adulthood on the brain peripheral tissues. These essential for establishment of biological axes responsible regulating behaviors, reproduction, stress, emotional responses. Estradiol (E2), testosterone, their metabolites through genomic non-genomic mechanisms, bounding canonical receptors, estrogen receptor (ER)α, ERβ, androgen (AR) or membrane G...
An interaction between melatonin and adrenocorticotropin (ACTH) seems to occur in humans both hormones respond beta‐adrenergic stimulation. As lower animal species, human pineal gland also contains α 2 ‐adrenergic receptors as does the hypothalamus‐pituitary axis. In this study response of hypothalamus‐pituitary‐adrenal axis stimulation was assessed. Twenty‐nine children (21 males, mean age 11.2±0.6 yr eight females, 9.1±1.1 yr) from University Granada Hospital were studied. The diagnosed...
The involvement of androgens in the regulation energy metabolism has been demonstrated. main objective present research was to study both programming and regulatory peptides associated with feeding. For this purpose, androgen receptors metabolic pathways testosterone were inhibited during first five days postnatal life male female Wistar rats. Pups received a daily s.c. injection from day birth, (P) 1, P5 Flutamide (a competitive inhibitor receptors), Letrozole (an aromatase inhibitor),...
Aim . To relate dental age and bone to chronological in a group of children with isolated growth hormone deficiency (GHD). Design A 25 between the ages 6 18 years, diagnosed as having GHD were studied. Of these, 16 male nine female, undergoing replacement therapy (GH) over 2·5 years. Dental (DA) was estimated from orthopantograms (Haavicko Methods) compared (BA) by Greulich Pyle Standards, (CA). Results CA versus BA – there statistically significant difference 1·52 years average ( t = 5·61,...
The objective of this study was to investigate the orexin and POMC populations in hypothalamic nuclei male Wistar rats after activity-based anorexia (ABA) procedure. Four groups were established based on food restriction activity: activity (A), ABA, diet (D) control (C). ABA protocol consisted free access a running wheel for period 22 h 1 h. When animals group reached criterion, sacrificed, their brains collected serially sectioned. free-floating sections processed immunostaining. number...
The pineal gland in humans is under both α‐ and β‐adrenergic control, although it seems that β 1 ‐adrenoceptors are mainly implicated melatonin secretion. In the present study, we evaluated role of innervation on production its relation with growth hormone (GH). Thirty‐four children (15 males 19 females, mean age 10.5±0.8 years) from University Granada Hospital were studied. included a protocol for evaluation delay using propranolol+exercise test. This standardized test allowed us to study...
In recent years we have witnessed a growing tendency to opt for the use of dopamine agonists (DA) as treatment Parkinson's disease (PD), with aim delaying far possible development fluctuations and dyskinesias. Yet, levodopa continues be most effective antiparkinson drug is probably one that improves greatest number symptoms disease. This article reports on results comprehensive review literature dealing benefits risks in patients PD which was conducted by group expert neurologists members...
Phytoestrogens are considered beneficial for health, but some studies have shown that they may cause adverse effects. This study investigated the effects of genistein administration during second week life on energy metabolism and circuits regulating food intake. Two different doses, 10 or 50 µg/g, were administered to male female rats from postnatal day (P) 6 P13. Physiological parameters, such as body weight caloric intake, then analyzed at P90. Moreover, proopiomelanocortin (POMC)...
To assess the existence of a possible nocturnal ultradian rhythm melatonin in children, we analyzed 28 pediatric patients (mean age, 9.08 +/- 2.2 yr) with GH-dependent and GH-independent growth delay. Plasma was measured by RIA children sampled every 30 min between 2100-0900 h. Statistical analysis consisted cluster to examine presence peaks troughs. The pattern levels related cause delay, although means concentrations were similar all children. Interestingly, GH deficit showed nearly normal...
Background Malnutrition during the early stages of development produces alterations that can compromise functioning hypothalamic circuits regulate food intake. The purpose this study is to analyze effects a low-protein and low-calorie diet has on morphology arcuate nucleus (ARC) hypothalamus in newborn male female rats. Methods On gestational day 6 (G6), six pregnant rats were divided into two groups. One group was made up three rats, which fed ad libitum with control (20% casein), other one...
In the present work we analyzed effects of postnatal exposure to two doses genistein (10 μg/g or 50 μg/g) from (P) day 6 P13, on morphology arcuate nucleus (Arc). The analyses Arc coronal brain sections at 90 days showed that ArcMP had higher values in volume, Nissl-stained neurons and GPER-ir males than females treatment with abolished these sex differences most parameters studied. Moreover, males, but not females, decreased increased ArcL both genistein. ArcLP, population lowest highest...
<p><strong>Background</strong>: Tree nuts and peanuts (henceforth, nuts) are nutrient-dense foods rich in neuroprotective components; thus, their consumption could benefit cognitive health. However, evidence to date is limited inconsistent regarding the potential benefits of for function.</p> <p><strong>Objective</strong>: To prospectively evaluate association between nut 2-y changes performance older adults at decline risk.</p>...
<p><strong>Background</strong>: Tree nuts and peanuts (henceforth, nuts) are nutrient-dense foods rich in neuroprotective components; thus, their consumption could benefit cognitive health. However, evidence to date is limited inconsistent regarding the potential benefits of for function.</p> <p><strong>Objective</strong>: To prospectively evaluate association between nut 2-y changes performance older adults at decline risk.</p>...
This study objective was to investigate the expression of orexin and POMC in hypothalamic nuclei male Wistar rats after activity-based anorexia (ABA) procedure. Methods: Four groups were established based on food restriction activity: activity (A), ABA, diet (D) control (C). When animals ABA group reached criterion (when their weights dropped below 75% for two consecutive days), sacrificed, brains collected, frozen serially sectioned along coronal plane at a thickness 40 μm. The...