A5010290058- Glaucoma and retinal disorders
- Ocular Surface and Contact Lens
- Ocular Infections and Treatments
- Immunotoxicology and immune responses
- Retinal Diseases and Treatments
- Retinal Development and Disorders
- Animal testing and alternatives
- Retinal and Optic Conditions
- Ocular Diseases and Behçet’s Syndrome
- Monoclonal and Polyclonal Antibodies Research
- Toxoplasma gondii Research Studies
- PARP inhibition in cancer therapy
- Anesthesia and Sedative Agents
- Ocular Disorders and Treatments
- Retinal and Macular Surgery
- Complement system in diseases
- Zebrafish Biomedical Research Applications
- Adenosine and Purinergic Signaling
- Ocular Oncology and Treatments
- Calcium signaling and nucleotide metabolism
- Veterinary Pharmacology and Anesthesia
- Retinoids in leukemia and cellular processes
- Virus-based gene therapy research
- Animal Behavior and Reproduction
- Biotin and Related Studies
AbbVie (United States)
2016-2024
Regeneron (United States)
2016
Allergan (United States)
2011-2013
The expansion of a hexanucleotide (GGGGCC) repeat in C9ORF72 is the most common cause amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Both function mechanism by which drives neuropathology are unknown. To examine whether haploinsufficiency induces neurological disease, we created C9orf72-deficient mouse line. Null mice developed robust immune phenotype characterized myeloid expansion, T cell activation, increased plasma cells. Mice also presented with elevated...
The eye, which is under constant exposure to environmental pathogens, has evolved various anatomic and immunological barriers critical the protection of tissues lacking regenerative capacity, maintenance a clear optic pathway essential vision. By bypassing ocular barriers, intravitreal (IVT) injection become mainstay for delivery drugs treat conditions that affect back eye. Both small molecules biotherapeutics have been successfully administered intravitreally, several approved treatment...
Nicotinamide phosphoribosyltransferase (NAMPT) has been investigated as a target for oncology because it catalyzes rate-limiting step in cellular energy metabolism to produce nicotinamide adenine dinucleotide. Small molecule inhibitors of NAMPT have promising drug candidates but preclinical development hindered due associated retinal toxicity. Here we demonstrate that larval zebrafish can predict toxicity with this mechanism revealing an attractive alternative method identifying such...
Nonclinical rodent studies with repeat slow intravenous dosing, such as safety assessments of anticancer therapeutics, often require the use animals surgically implanted catheters. Catheterization is a relatively short surgical procedure but requires anesthesia. Ketamine/xylazine injectable anesthesia typically used because it has advantages over inhalation including ease administration, and predictability effects, low cost. However, ketamine/xylazine in rodents can also be associated...
A Working Group of the Society Toxicologic Pathology's Scientific and Regulatory Policy Committee conducted a technical scientific review current practices relating to fixation, trimming, sectioning nonrodent eye identify key points species-specific anatomical landmarks consider when preparing evaluating eyes rabbits, dogs, minipigs, nonhuman primates from ocular general toxicity studies. The topics addressed in this Points Consider article include determination situations more comprehensive...
Monthly blood samples, daily mating observations from Galapagos tortoises (Chelonoidis nigra), and local rainfall temperature were collected at the Honolulu Zoo as part of a fertility evaluation. Testosterone concentrations measured for males (n = 6), two which seen copulating considered sexually active. Estrone sulfate progesterone female 9), nested only one had laid eggs. profiles similar both active inactive males, positively correlated with but not rainfall. Peak testosterone (12.0 ± 1.4...
Dysfunction of the visual system remains a leading cause human disability worldwide. Preclinical studies are key component efforts to develop drugs and devices ameliorate impairment. Although new opportunities for delivery targeted ocular therapeutics have been created, clinical success has confounded by unique challenges drug development eye. This Special Issue brings together broad range articles that augment our current understanding highlight methods assessing toxicity some in...