A5001634991- Neurogenesis and neuroplasticity mechanisms
- Peroxisome Proliferator-Activated Receptors
- Cell death mechanisms and regulation
- Nerve injury and regeneration
- Cancer Cells and Metastasis
- Axon Guidance and Neuronal Signaling
- Receptor Mechanisms and Signaling
- Cholesterol and Lipid Metabolism
- T-cell and B-cell Immunology
- Drug Transport and Resistance Mechanisms
- Retinal Diseases and Treatments
- CAR-T cell therapy research
- Immune Cell Function and Interaction
- Ocular Infections and Treatments
- Intraocular Surgery and Lenses
- Lung Cancer Research Studies
- Cancer Genomics and Diagnostics
- Glaucoma and retinal disorders
- Cardiac electrophysiology and arrhythmias
- Fatty Acid Research and Health
- Zebrafish Biomedical Research Applications
- Adipokines, Inflammation, and Metabolic Diseases
- Retinal and Optic Conditions
- Lymphoma Diagnosis and Treatment
- ATP Synthase and ATPases Research
University Hospital of Basel
2023
University of Basel
2023
Max Rubner Institut
2009-2018
SRH Wald-Klinikum Gera
2016-2017
Allergan (United States)
2013-2016
Georg Speyer Haus
2012-2013
Goethe University Frankfurt
2013
University of California, San Diego
2009-2012
TU Dresden
2009
University of California, Los Angeles
2004-2008
Reactive astrocytes are prominent in the cellular response to spinal cord injury (SCI), but their roles not well understood. We used a transgenic mouse model study consequences of selective and conditional ablation reactive after stab or crush SCI. Mice expressing glial fibrillary acid protein-herpes simplex virus-thymidine kinase transgene were given mild moderate SCI treated with antiviral agent ganciclovir (GCV) ablate dividing, reactive, transgene-expressing immediate vicinity Small...
Signaling mechanisms that regulate astrocyte reactivity and scar formation after spinal cord injury (SCI) are not well defined. We used the Cre recombinase (Cre)-loxP system under regulation of mouse glial fibrillary acidic protein (GFAP) promoter to conditionally delete cytokine growth factor signal transducer, transducer activator transcription 3 (STAT3), from astrocytes. After SCI in GFAP-Cre reporter mice, >99% cells exhibited activity as detected by expression were GFAP-expressing...
The inhibitor of apoptosis proteins (IAPs) regulate the caspase family cysteine proteases, which play an important role in execution programmed cell death. Human X-linked protein (XIAP) is a potent caspases-3, -7, and -9. Here we show that Bir3 domain minimal region XIAP needed for caspase-9 inhibition. three-dimensional structure XIAP, determined by NMR spectroscopy, resembles classical zinc finger consists five α-helices, three-stranded β-sheet, atom chelated to three cysteines one...
A series of oxamyl dipeptides were optimized for pan caspase inhibition, anti-apoptotic cellular activity and in vivo efficacy. This structure-activity relationship study focused on the P4 oxamides warhead moieties. Primarily basis vitro data, inhibitors selected a murine model alpha-Fas-induced liver injury. IDN-6556 (1) was further profiled additional models pharmacokinetic studies. first-in-class inhibitor is now subject two Phase II clinical trials, evaluating its safety efficacy use disease.
The fatty acid transport protein 5 (FATP5) is exclusively expressed in the liver and involved hepatic lipid bile metabolism. We investigated whether a variation FATP5 promoter (rs56225452) associated with steatosis further features of metabolic syndrome. A total 716 male subjects from Metabolic Intervention Cohort Kiel (MICK) 103 histologically proved nonalcoholic disease (NAFLD) were genotyped for this polymorphism rs56225452 phenotyped In MICK cohort, ALT activities, postprandial insulin,...
Repulsive Eph forward signaling from limb-derived ephrins guides the axons of lateral motor column (LMC) neurons. LMC also express ephrinAs, while their EphA receptors are expressed in limb mesenchyme. In vitro studies have suggested that reverse EphA4 to axonal ephrinAs might result attraction axons. However, genetic evidence for this function is lacking. Here we use Dunn chamber turning assay show proteins chemoattractants and elicit fast responses neurons . Moreover, ectopic expression...
Cefepime is recommended for treating infections caused by AmpC beta-lactamase-producing Enterobacterales (AmpC-PE), though supporting evidence limited. Therefore, this study compared outcomes associated with cefepime versus carbapenem therapy bloodstream (BSIs) AmpC-PE after phenotypic exclusion of ESBL-co-producing isolates.
Peroxisome proliferator-activated receptor (PPAR)γ is a key regulator in adipose tissue. The rare variant Pro12Ala of PPARγ2 associated with decreased risk insulin resistance. Being dietary PPARγ ligands, conjugated linoleic acids (CLAs) received considerable attention because their effects on body composition, cancer, atherosclerosis, diabetes, obesity and inflammation, although some were only demonstrated animal trials the results human studies not always consistent. In present study CLA...
The main goal of this experiment was to study the effect milk fat depression, induced by supplementing diet with plant oils, on bovine metabolism, special interest in cholesterol levels. For purpose 39 cows were divided three groups and fed different rations: a control group (C) without any oil supplementation two soybean (SO) or rapeseed (RO) added partial mixed ration (PMR). A decrease percentage observed both feedings higher −1·14 % SO than RO −0·98 compared physiological (−0·15 %)...
AbstractFatty acids binding proteins (FABPs) are involved in uptake, binding, transport and metabolism of fatty (FAs). Although FAs known to stimulate insulin secretion from pancreatic islets when transiently elevated, while contributing islet loss function, lipotoxicity apoptosis chronically almost nothing is regarding the FABPs this tissue. The present study aimed at exploring expression pattern regulation rat insulin-secreting INS-1E cells. Rat cells expressed heart/muscle type (FABP3)...
Abstract Ephrins and Eph receptor tyrosine kinases are cell‐surface molecules that serve a multitude of functions in cell–cell communication development, physiology, disease. EphA4 is promiscuous member the EphA subclass receptors can bind to both EphrinAs EphrinBs. In addition its well‐established roles guiding development neuronal connectivity, has been implicated for role synaptic plasticity, vascular formation, axon regeneration, central nervous system repair following injury. However,...
Familial non-Hodgkin lymphoma (NHL) cases were classified according to the histologic criteria (modified) of Rappaport, determine extent morphologic similarities tumors. In four families affected members had different tumor histologies that may be observed in an individual patient as progresses. two families, relatives tumors seemingly discordant histology. These nonetheless etiologically related indicated by pattern laboratory abnormalities, especially immunologic, well unaffected members....