Background: Conventional interferon and lamivudine monotherapy are unsatisfactory in treating hepatitis B virus (HBV) infection. Objective: To evaluate the efficacy safety of pegylatedinterferon-α2b combination therapy for chronic B. Design: Randomized, controlled, open-label trial. Setting: Outpatient clinic a referral center. Participants: 100 treatment-naive patients with e antigen (HBeAg)–positive moderately elevated alanine aminotransferase levels. Measurement: The primary end point was...

OBJECTIVE Histological assessment of liver fibrosis is important in the management chronic hepatitis B (CHB) infection but poorly accepted by patients because its invasiveness. The aim this study was to develop a noninvasive model assess CHB using clinical and routine laboratory data. PATIENTS AND METHODS This retrospective on 235 treatment-naïve viremic patients. Univariate analysis data from training cohort (n = 150) followed multivariate logistic regression were performed identify...

Increased serum haptoglobin concentration and changes in its glycosylation have been reported certain cancer types. Information for hepatocellular carcinoma (HCC) has not yet available. In this study, we aimed to carry out a systematic analysis of concentrations (Hp) glycoforms the patients with HCC noncancer only chronic liver diseases (CLD) examine their clinical values. This study was divided into two major parts, (1) measurement Hp concentration, investigation value diagnosis HCC, (2)...

ABSTRACT One hundred forty-six hepatitis B e antigen (HBeAg)-positive chronic patients were followed up for 32 ± 13 months. All six with hepatocellular carcinoma had virus (HBV) genotype C. Disease activity was greater in infected by HBV C than those the HBeAg-positive phase but not after HBeAg seroconversion.

Abstract Background: Most noninvasive predictive models of liver fibrosis are complicated and have suboptimal sensitivity. This study was designed to identify serum proteomic signatures associated with develop a proteome-based fingerprinting model for prediction fibrosis. Methods: Serum proteins from 46 patients chronic hepatitis B (CHB) were profiled quantitatively on surface-enhanced laser desorption/ionization (SELDI) ProteinChip arrays. The identified fibrosis-associated fingerprint used...

Non-alcoholic fatty liver disease (NAFLD) is the most common chronic in affluent countries. Serum alanine aminotransferase (ALT) level commonly performed to monitor NAFLD patients, but its clinical relevance unclear.To evaluate metabolic and histological features of patients with different ALT levels.A total 173 consecutive biopsy-proven were studied. Patients persistently normal those abnormal compared.Patients had lower steatosis grade than ALT, they similar degree lobular inflammation,...

Nonalcoholic fatty liver disease (NAFLD) is increasing in prevalence worldwide. This study aimed to validate the NAFLD fibrosis score Chinese population.NAFLD patients were prospectively recruited for biopsy and blood tests. The was calculated as -1.675 + 0.037 x age (yr) 0.094 BMI (kg/m(2)) 1.13 impaired fasting glucose/diabetes (yes = 1, no 0) 0.99 AST/ALT ratio-0.013 platelet (x10(9)/L)-0.66 albumin (g/dL). Advanced defined stage 3 4 fibrosis.One hundred sixty-two (age 46 +/- 10 yr, male...

Purpose. To investigate the uptake and delivery of anti-allergy drug ketotifen fumarate (KF) by commercially available contact lenses. Methods. A total 14 different lenses were investigated, including five frequent-replacement silicone hydrogels, three conventional six daily disposable Lenses soaked in a 0.025% KF loading solution for 24 h, concentration over time was determined ultraviolet absorbance at 297 nm. After 24-h period, placed fresh vials containing borate buffered saline, release...

The purpose of this study was to evaluate ciprofloxacin-releasing silicone hydrogel contact lens materials in vitro and vivo for the treatment microbial keratitis.Model were manufactured using a molecular imprinting technique modify ciprofloxacin release kinetics. Various properties, including light transmission surface wettability, determined, kinetics elucidated fluorescence spectrophotometry. then evaluated their ability inhibit Pseudomonas aeruginosa growth an rabbit model...

Summary Background Non‐alcoholic fatty liver disease is prevalent in affluent countries and strongly associated with metabolic syndrome. Aim To study the prevalence of undiagnosed diabetes postchallenge hyperglycaemia Chinese patients non‐alcoholic disease. Methods 73 consecutive biopsy‐proven no history underwent comprehensive screening. Diagnosis impaired glucose regulation was based on 2006 American Diabetes Association criteria. Results The tolerance 33% 29%, respectively. Among 2‐h...

Summary Background : Non‐alcoholic fatty liver disease is an important cause of chronic hepatitis and cryptogenic cirrhosis. The natural history non‐alcoholic not well understood especially in Asian populations. Aim To investigate the histological progression Chinese patients with biopsy‐proven disease. Methods who had biopsy at least 3 years ago confirmed to have were invited for a second biopsy. Clinical laboratory parameters related their function metabolic syndrome recorded analysed....

Objectives To investigate the uptake and release kinetics of synthetic glucocorticoid anti-inflammatory drug dexamethasone into various conventional silicone hydrogel contact lens materials. Methods Three six lenses were used in this study. A 0.1% solution was formulated to dope The measured using a UV-visible light spectrophotometer at time points during period 24 hr for each phase. Results Statistical analysis showed that all took up significant amount dexamethasone. Alphafilcon...

Objectives. To investigate the uptake and release characteristics of antibiotic ciprofloxacin-HCl in conventional silicone hydrogel lenses, evaluate their potential as therapeutic drug delivery devices. Methods. Nine differing soft contact lens materials were soaked a 0.3% solution at 34°C. The into lenses was measured by change concentration over 24 hours using fluorescence spectrophotometry. then placed buffered saline solution, from also Results. varied 0.016 ± 0.004 mg/lens for...

To determine the 2-year survival and prognostic indicators of hepatitis B virus-related cirrhosis after onset hepatic decompensation.Chronic (CHB) patients with resultant decompensation have reduced survival. However, natural history these has not been well characterized in previous studies. Better understanding is essential management patients, especially determining who should be candidates for orthotopic liver transplantation.This a retrospective longitudinal study 96 CHB-related...

We have previously demonstrated that combination peginterferon and lamivudine treatment has superior antiviral efficacy to monotherapy in chronic hepatitis B. In this study, we investigated the long-term posttreatment virological response treatment. Sustained of patients who completed 32-week 52-week was compared monotherapy. defined as sustained B e antigen (HBeAg) loss HBV DNA < 100,000 copies/mL from cessation until end follow-up. Forty-eight receiving 47 were studied. The follow-up...

Hypoadiponectinemia and high tumor necrosis factor-alpha (TNF-alpha) levels are associated with the development of nonalcoholic fatty liver disease (NAFLD). This study aimed to investigate genetic polymorphisms adiponectin TNF-alpha in Chinese NAFLD patients their association severity.Seventy-nine histology-proven (61 simple steatosis 18 stage 2-4 fibrosis) 40 controls were tested for nucleotide at -11 391, 377, +45, +276 promoters -863, -308, -238.There was no significant deviation gene...

Contact lenses, as an alternative drug delivery vehicle for the eye compared to drops, are desirable due potential advantages in dosing regimen, bioavailability and patient tolerance/compliance. The challenge has been engineer develop these materials sustain a long period of time. In this study, model silicone hydrogel were created using molecular imprinting strategy deliver antibiotic ciprofloxacin. Acetic acrylic acid used functional monomers, interact with ciprofloxacin template...

BackgroundOcular infections caused by antibiotic-resistant pathogens can result in partial or complete vision loss. The development of pan-resistant microbial strains poses a significant challenge for clinicians as there are limited antimicrobial options available. Synthetic peptoids, which sequence-specific oligo-N-substituted glycines, offer potential alternative agents to target multidrug-resistant bacteria.MethodsThe activity synthesised peptoids against (MDR) ocular was evaluated using...

SIGNIFICANCE Although human adenoviruses are the leading cause of acute viral conjunctivitis, there is a lack data surrounding efficacy contact lens care products against these viruses. PURPOSE This study investigates antiviral activity several commercially available solutions adenovirus type 5 (Ad5). METHODS Six (Biotrue, Boston Simplus, OPTI-FREE Puremoist, Clear Care, cleadew, and cleadew GP) were investigated. Quantitative suspensions tests conducted on Ad5 after interaction with...

Myopia or near-sightedness is a global vision problem. Atropine eye drops and myopia-controlling contact lenses can help to slow down its progression, but neither sufficient alone. The present research work was conducted design lens embedded with an atropine base within microemulsion system. goal improve the stability of facilitate release from lens, preventing rapid clearance observed drops. Two microemulsions, one pH 7.4 other 6.5, were developed using surfactant D-alpha-tocopherol...