A5060516072- Platelet Disorders and Treatments
- Antiplatelet Therapy and Cardiovascular Diseases
- Blood properties and coagulation
- Antioxidant Activity and Oxidative Stress
- Venous Thromboembolism Diagnosis and Management
- Laser Applications in Dentistry and Medicine
- Atherosclerosis and Cardiovascular Diseases
- Adrenal Hormones and Disorders
- Lipoproteins and Cardiovascular Health
- Eicosanoids and Hypertension Pharmacology
- Inflammatory mediators and NSAID effects
- Glycosylation and Glycoproteins Research
- Vitamin K Research Studies
- Synthesis and biological activity
- Blood disorders and treatments
- Cerebrovascular and Carotid Artery Diseases
- Vitamin C and Antioxidants Research
- Blood Coagulation and Thrombosis Mechanisms
- Ocular and Laser Science Research
- Nitric Oxide and Endothelin Effects
- Peroxisome Proliferator-Activated Receptors
- Estrogen and related hormone effects
- Diabetes Treatment and Management
- Geological Formations and Processes Exploration
- Fatty Acid Research and Health
University of Szeged
2021-2022
HUN-REN Szegedi Biológiai Kutatóközpont
2022
Institute of Genetics
2022
Hungarian Research Network
2022
St Bartholomew's Hospital
1986-1999
William Harvey Research Institute
1991-1999
University of Cambridge
1984-1989
King's College School
1986-1988
King's College Hospital
1981-1988
Thrombosis Research Institute
1986-1988
Plasma lipid peroxide concentrations were measured in 100 patients with occlusive arterial disease proved angiographically (50 ischaemic heart disease, 50 peripheral disease) and compared values 75 control no clinical evidence of atherosclerosis. Lipid significantly higher both (median 4.37 mumol/l (interquartile range 3.85-5.75 mumol/l); p less than 0.001) (3.88-5.21 controls 3.65 3.29-3.89 mumol/l). Overall there was a significant but weak correlation between plasma triglyceride (rs =...
The indirect flight muscle is a widely used model for studying sarcomere structure and development due to its extremely regular architecture. Nevertheless, precise measurement of the basic sarcomeric parameters remains challenge even in this greatly ordered tissue. In study, we identified several factors affecting reliability developed software tool precise, high-throughput length myofibril width. accuracy new was validated against simulated images blinded manual measurements. To extend...
SUMMARY Experiments are described which show that the in vitro synthesis of corticosterone under influence ACTH is inhibited by hydrocortisone, prednisolone and dexamethasone relative potency these three substances corresponds to their clinical anti-inflammatory activity. It suggested a direct adrenal inhibitory mechanism plays physiological pharmacological role, addition regulatory controlling steroid function mediated pituitary.
The only certain physiological function of platelets is their aggregation in injured vessel walls as haemostatic plugs. association thrombocytopenia with petechial haemorrhages suggests that are somehow required for the functional integrity small vessels, but no mechanism has yet been established. pathological thrombi atherosclerotic arteries commonly, if not always, initiated by haemorrhage. In artificial tend to aggregate on wherever blood flow non-laminar. mural prevented...
The contribution of the net negative charge excess due to sialic acids on endothelium in preventing adhesion circulating platelets vivo was investigated anaesthetized rabbits. Platelets rabbit's circulation were selectively labelled with radioactive 5-hydroxytryptamine vivo. Segments carotid arteries temporarily isolated from perfused one or other two commercial preparations neuraminidase; opposite artery similarly without enzyme, as control. A neuraminidase preparation Behringwerke free...
The specificity of an iodometric assay for measuring lipid peroxides in lipoproteins was tested, compared with the fluorimetric thiobarbituric acid assay, and adopted detecting peroxide plasma samples. Oxidation low density vitro by Cu2+, lipoxidase, phagocytosing polymorphonuclear leucocytes sensitively detected assay. Unlike neither non-lipid substances commonly present plasma, nor platelet or leucocyte by-products interfered measured a normal mean (SD) concentration 10.8 (2.1) microM; n =...
Abstract Aggregation of red cells rat in saline suspension was induced by gelatin, high molecular weight dextran and fibrinogen. Except chloroquine, non-steroidal anti-inflammatory agents (NAIA) inhibited macromolecule-induced cell aggregation vitro. Glucocorticoids failed to inhibit even large concentrations. Of many drugs examined, only the NAIA certain antihistamines, having experimental effects proved be effective inhibitors gelatin-induced aggregation,