A5025641243- Cardiac Valve Diseases and Treatments
- Acute Myocardial Infarction Research
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiovascular Function and Risk Factors
- Coronary Interventions and Diagnostics
- Cardiac Structural Anomalies and Repair
- Venous Thromboembolism Diagnosis and Management
- Gout, Hyperuricemia, Uric Acid
- Atrial Fibrillation Management and Outcomes
- Mechanical Circulatory Support Devices
- Inflammasome and immune disorders
- Cardiac Imaging and Diagnostics
- Pulmonary Hypertension Research and Treatments
- Cardiac Arrhythmias and Treatments
- Cardiac pacing and defibrillation studies
- Cardiac Arrest and Resuscitation
- Coronary Artery Anomalies
- Infective Endocarditis Diagnosis and Management
- Acute Kidney Injury Research
- Adipokines, Inflammation, and Metabolic Diseases
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Congenital Heart Disease Studies
- Aortic Disease and Treatment Approaches
- Inflammatory Biomarkers in Disease Prognosis
- Cardiac and Coronary Surgery Techniques
Policlinico San Matteo Fondazione
2019-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2018-2025
Ospedale Vito Fazzi
2023-2025
University of Pavia
2017-2023
Ospedale Policlinico San Martino
2022
Leiden University Medical Center
2021
Foundation Center
2020
University of the Sacred Heart
2018
Università Cattolica del Sacro Cuore
2018
There is a lack of evidence to guide treatment patients with concomitant indication for transcatheter aortic valve implantation (TAVI) and complex, high-risk percutaneous coronary intervention (PCI). We aimed assess different strategies PCI timing in this TAVI cohort. The ASCoP registry retrospectively included clinical both at least 1 criterion complex or PCI. primary endpoint was composite all-cause death unplanned rehospitalisation cardiovascular causes. secondary death, stroke, acute...
Coronary artery ectasia (CAE) is described in 5% of patients undergoing coronary angiography. Previous studies have shown controversial results regarding the prognostic impact CAE. The prevalence and value CAE with acute myocardial infarction (AMI) remain unknown. In 4788 presenting AMI referred for angiography presence (defined as dilation a segment diameter ≥1.5 times adjacent normal segment) was confirmed 174 (3.6%) (age 62 ± 12 years; 81% male), present culprit vessel 79.9%. Multivessel...
Abstract Background Transcatheter edge‐to‐edge repair (TEER) for severe functional mitral regurgitation (FMR) in patients with reduced left ventricular ejection fraction (LVEF) may lead to an acute increase afterload, termed afterload mismatch (AM). This study aimed redefine AM clinically, analyse its determinants, and assess prognostic impact post‐TEER FMR patients. Methods A multicenter case–control was conducted, involving LVEF ≤35% undergoing TEER. defined as the (within 24 h) need...
Aims Elevated serum uric acid (eSUA) was associated with unfavorable outcome in patients ST-segment elevation myocardial infarction (STEMI). However, the effect of eSUA on reperfusion injury and infarct size has been poorly investigated. Our aim to correlate size, shrinkage, grade long-term mortality STEMI undergoing primary percutaneous coronary intervention. Methods We performed a post-hoc patients-level analysis two randomized controlled trials, testing strategies for ischemia/reperfusion...
Abstract Aims Dual antiplatelet therapy (DAPT) with a P2Y12 inhibitor on top of aspirin is the cornerstone after acute coronary syndromes (ACS). Nonetheless, safest and most efficacious for older patients who are both at high ischaemic bleeding risk remains uncertain. We aimed to examine effect available inhibitors endpoints in adults ACS. Methods results Randomized clinical trials that reported separately >70 years least primary endpoint [composite death, myocardial infarction (MI),...
Mandurino-Mirizzi, Alessandro; Demarchi, Andrea; Ruffinazzi, Marta; Cornara, Stefano; Somaschini, Alberto; Crimi, Gabriele; Ferlini, Marco; Camporotondo, Rita; Gnecchi, Massimiliano; Ferrario, Maurizio; Oltrona Visconti, Luigi; De Ferrari, Gaetano Maria Author Information
Background and Objectives. Recent guidelines have downgraded the routine use of intra-aortic balloon pump (IABP) in patients with cardiogenic shock (CS) due to ST-elevation myocardial infarction (STEMI). Despite this, its clinical practice remains high. The aim this study was evaluate prognostic impact IABP STEMI complicated by CS undergoing primary PCI (pPCI), focusing on anterior MI whom a major benefit has been previously hypothesized. Materials Methods. We enrolled 2958 consecutive pPCI...
Transcatheter edge-to-edge repair (TEER) with the MitraClip system (Abbott; Menlo Park, California, USA) represents a therapeutic option for functional mitral regurgitation (FMR) by reducing symptoms and improving clinical outcomes in selected patients.1, 2 In chronic MR, long-standing volume overload left-sided chambers leads to development of pulmonary hypertension (PH).3 The right ventricle (RV) initially responds increased afterload remodelling enlargement, but eventually ventricular...
Abnormal blood viscosity favors atherosclerosis owing to endothelial dysfunction and changes in shear stress. Its effect on coronary microvasculature during percutaneous intervention (PCI) is still unknown. We aimed investigate the role of hemorheological parameters incidence microvascular obstruction (MVO) periprocedural necrosis after primary or elective PCI, secondarily, we evaluated their prognostic significance.We enrolled 25 patients with ST-elevation myocardial infarction (STEMI), 30...