A5011540560- Telomeres, Telomerase, and Senescence
- Mitochondrial Function and Pathology
- Cancer-related Molecular Pathways
- DNA Repair Mechanisms
- Genetics, Aging, and Longevity in Model Organisms
- T-cell and Retrovirus Studies
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cytomegalovirus and herpesvirus research
- CRISPR and Genetic Engineering
- Immune Cell Function and Interaction
- Nuclear Receptors and Signaling
- Chromosomal and Genetic Variations
Brigham and Women's Hospital
2021
Harvard University
2014-2021
Université Libre de Bruxelles
2021
École Normale Supérieure de Lyon
2011-2013
Université Claude Bernard Lyon 1
2011-2013
Centre National de la Recherche Scientifique
2011-2013
Université Côte d'Azur
2011
Inserm
2011
Laboratoire de Biologie et Modélisation de la Cellule
2011
Significance The naked mole rat is a longest lived and cancer-resistant rodent. Tumor resistance in the mediated by signals from extracellular matrix component hyaluronan triggering induction of INK4 (inhibitors cyclin dependent kinase 4) locus expression. human mouse encodes three critical tumor-suppressor proteins, p15 INK4b , ARF (alternate reading frame), p16 INK4a which are among most frequently mutated cancer. Furthermore, implicated aging senescence. Here, we show that an additional...
Naked mole rat TRF1 enhances telomeric and metabolic functions in hypoxia through an evolutionary gain of function.