A5103019740- Analytical chemistry methods development
- Effects and risks of endocrine disrupting chemicals
- Bacterial Identification and Susceptibility Testing
- Antibiotics Pharmacokinetics and Efficacy
- Metabolomics and Mass Spectrometry Studies
- Gallbladder and Bile Duct Disorders
- Advanced biosensing and bioanalysis techniques
- Antibiotic Resistance in Bacteria
- Alcohol Consumption and Health Effects
- Biliary and Gastrointestinal Fistulas
- Pediatric Hepatobiliary Diseases and Treatments
- Pharmaceutical and Antibiotic Environmental Impacts
- RNA Interference and Gene Delivery
- Electrochemical Analysis and Applications
- Metabolism and Genetic Disorders
- DNA and Nucleic Acid Chemistry
Shanghai East Hospital
2019-2022
University of the Pacific
2020
Wenzhou Medical University
2016
Abstract In this paper, we report the synthesis of a phenanthroline and neomycin conjugate ( 7 ). Compound binds to human telomeric G‐quadruplex G1 ) with higher affinity compared its parent compounds (phenanthroline neomycin), which is determined by several biophysical studies. shows good selectivity for (G4) DNA over duplex DNA. The binding predominantly enthalpy‐driven, stoichiometry one tight‐binding event as ESI mass spectrometry. A plausible mode synergistic effect end‐stacking groove...
This study aimed to explore the alteration of bile acid (BA) profiles in patients with choledocholithiasis (CDC) and construct a prediction model for evaluating risk common duct stone (CBDS) recurrence after endoscopic treatment.A total 320 (218 CDC 102 nonneoplastic polyps) were enrolled. The serum BA compared between groups. Both diagnostic score prognostic CBDS based on BAs established by least absolute shrinkage selection operator regression. A nomogram was developed combining clinical...
Objective To establish an ultra high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) method for detecting α-hydroxybutyrate (α-HB) in serum. Methods Electrospray ionization negative ion and multiple reaction monitoring mode were used to detect serum α-HB. The linearity, low limits of quantification, precision, recovery interference UHPLC-MS/MS evaluated. reference interval this was established 130 samples (62 males 68 females) from Shanghai East Hospital....