A5102024294- Dementia and Cognitive Impairment Research
- Frailty in Older Adults
- Nutrition and Health in Aging
- Health Systems, Economic Evaluations, Quality of Life
- Health disparities and outcomes
- Stroke Rehabilitation and Recovery
- Employment and Welfare Studies
- CAR-T cell therapy research
- Blood Pressure and Hypertension Studies
- Monoclonal and Polyclonal Antibodies Research
- Health and Well-being Studies
- Health, psychology, and well-being
- Cerebral Palsy and Movement Disorders
- Alzheimer's disease research and treatments
- Functional Brain Connectivity Studies
- Biosimilars and Bioanalytical Methods
- Chronic Disease Management Strategies
- Primary Care and Health Outcomes
- Nutritional Studies and Diet
- Migration and Labor Dynamics
- Geriatric Care and Nursing Homes
- Interprofessional Education and Collaboration
- T-cell and B-cell Immunology
- Health and Wellbeing Research
- Psychosomatic Disorders and Their Treatments
AbCellera (Canada)
2024
Chinese University of Hong Kong
2010-2023
Hong Kong Jockey Club
2021-2023
University of Toronto
2015
Tai Po Hospital
2010
University of Hong Kong
2008
Abstract Objectives We reported the interim findings of a randomized controlled trial (RCT) to examine effects mind body physical exercise (Tai Chi) on cognitive function in Chinese subjects at risk decline. Subjects 389 older persons with either Clinical Dementia Rating (CDR 0.5) or amnestic‐MCI participated an program. The intervention lasted for 1 year; 171 were trained 24 forms simplified Tai Chi (Intervention, I) and 218 stretching toning (Control, C). comprised advised sessions least...
Background: studies have suggested that neuropsychiatric (NP) symptoms influence the development of dementia among older adults. But, results are inconsistent and there is limited information about NP in population-based samples.
To examine whether intrinsic capacity (IC) could predict frailty, declines in specific domains of IC lead to and different combinations represent risks developing frailty.
(1) Objective: This study examined the effects of a combined intervention Brainastic computerized cognitive training (CCT) preceded by physical exercise (PE) for improving frailty status and function in older adults. (2) Methods: Older adults aged 50 years or attending elderly centers, without frailty/history impairment, were randomly allocated into either 12-week (i) multi-domain CCT + PE (n = 117), (ii) two-domain 116) (iii) video watching (i.e., control, n 114). is an online application...
In Hong Kong, older Chinese adults generally have a low level of education. This study examined the effect education on very mild Alzheimer's disease (AD), as quantified by Clinical Dementia Rating (CDR) scale (CDR 0.5 versus 0), in community. The Cantonese version Mini-Mental State Examination (C-MMSE) was used to estimate cognitive abilities that were related education, and turn serve protective factors for AD.A total 788 community-dwelling (383 CDR 0 405 0.5) recruited this...
Abstract Engagement of the CD28 co-receptor by T-cell engager (TCE) molecules can enhance activation, proliferation, and anti-tumor activities, particularly in immunosuppressive tumor microenvironments. In this study, we present data on a diverse panel CD28-binding IgG heavy chain-only (HCAb) antibodies for co-stimulation. Our add co-stimulatory building blocks to our TCE repertoire. Using single B cell-screening, identified fully human HCAb binders non-human primate with high degree...
<h3>Background</h3> CD3 T-cell engagers (TCEs) represent a promising approach in cancer immunotherapy, yet challenges efficacy and safety have hindered clinical development. To address these barriers, we developed TCE platform comprised of novel CD3-binding antibodies, bispecific engineering technology, high-throughput process for identifying pairs CD3- tumor-binding antibodies with desired properties. By assessing hundreds formats, identified rare CD3-binders that can be used to create TCEs...
Evidence on the effectiveness of cooking activities as a well-being promotion intervention for older adults with subjective cognitive decline (SCD) and their caregivers is scarce. In view this, randomized controlled trial was conducted to examine whether dyadic cooking-based can improve health SCD caregivers, well competence former group. Randomized trial. Community. Sixty pairs community-dwelling aged 60 years or above (mean age = 78.4 years) 65.3 were randomly assigned group (N 30 pairs)...
This study examined the psychometric properties of Cantonese version SarQoL® questionnaire.A total 118 (including 60 non-sarcopenic and 58 sarcopenic) community-dwelling older adults aged 65 years or above with as their mother tongue.Translation cultural adaptation SarQoL were conducted using a standardized protocol. To validate SarQoL, including discriminative power, reliability internal consistency test-retest reliability), construct validity convergent divergent validity), well floor...