Allison Goodman
A5075985939- Immune Cell Function and Interaction
- CAR-T cell therapy research
- Immunotherapy and Immune Responses
- Phagocytosis and Immune Regulation
- Immune cells in cancer
- Monoclonal and Polyclonal Antibodies Research
- Cancer Immunotherapy and Biomarkers
- T-cell and Retrovirus Studies
- Biosimilars and Bioanalytical Methods
- Nanofabrication and Lithography Techniques
- Advanced Biosensing Techniques and Applications
- Gender Diversity and Inequality
- Cultural Industries and Urban Development
- Technology Assessment and Management
- Protein purification and stability
- Neuroscience and Neural Engineering
- Career Development and Diversity
AbCellera (Canada)
2023-2024
ArtCenter College of Design
2024
Bureau of Labor Statistics
2024
United States Department of Labor
2024
Tumor-associated macrophages (TAM) play an important role in maintaining the immunosuppressive state of tumor microenvironment (TME). High levels CD163+ TAMs specifically are associated with poor prognosis many solid types. Targeting may represent a key approach development next generation cancer immune therapeutics. Members leukocyte immunoglobulin-like receptor B (LILRB) family, including LILRB2 (ILT4), known to transmit inhibitory signals and other myeloid cells. Leveraging bulk single...
Abstract Accessing peptides from intracellular tumor antigens displayed on MHC class I (pMHC) can expand the T-cell engager (TCE) target pool for solid applications. A challenge limiting TCE development pMHC targets is identification of rare, high-affinity, and high-specificity pMHC-binders. In this work, we describe TCEs in a 1 × format with potent tumor-cell killing activity high specificity MAGE-A4, antigen expressed multiple cancer types. We identified functional MAGE-A4 x CD3 affinity...
<h3>Background</h3> CD3 T-cell engagers (TCEs) represent a promising approach in cancer immunotherapy, yet challenges efficacy and safety have hindered clinical development. To address these barriers, we developed TCE platform comprised of novel CD3-binding antibodies, bispecific engineering technology, high-throughput process for identifying pairs CD3- tumor-binding antibodies with desired properties. By assessing hundreds formats, identified rare CD3-binders that can be used to create TCEs...
Abstract The research detailed in this paper focuses on the career experiences of women who obtained degrees between 1979 and 1983. Exploring women's achievements, challenges, reflections their work STEM professions using Social Cognitive Career Theory, recommendations are provided for educators to prepare both men long term professional careers. Especially women, being equipped with research-based, practical skills strategies has potential increase retention these professions.
Abstract In this study, we used a functional approach to generate CD3 T-cell engager (TCE) molecules targeting prostate-specific membrane antigen (PSMA). We present data on the robust in vitro characterization of activity and selection for further assessment. TCE function is dictated by interplay between multiple factors that form immune synapse, including binding kinetics, geometry, epitopes CD3- tumor-binding arms. To diversify synapse parameters, engineer hundreds bispecific from highly...
Abstract In this study, we present data from four T-cell engager (TCE) programs in which leveraged our highly diverse CD3-binding antibodies to generate functional bispecifics for each tumor target. By aggregating tumor-cell killing and cytokine across targets with different properties target expression levels, have gained novel insights into target-specific considerations the development of CD3 TCEs. TCEs recapitulate a synapse between T cells cells. cell function downstream is determined...
<p>Sensitivity of LILRB2 as a predictive biomarker for pharmacodynamic response measured by the macrophage polarization score in histoculture explant cultures.</p>
<p>Example gating strategy for blood monocytes</p>
<p>Example gating strategy in vitro differentiated GM-CSF and IL-4 Dendritic Cells</p>
<p>Changes in gene expression by JTX-8064 both macrophages and dendritic cells 6 days on treatment during differentiation</p>
<p>Example gating strategy in vitro differentiated M-CSF macrophages</p>
<p>Example gating strategy for tumor samples in order to acquire CD163 and LILRB2 + cells</p>
<p>A Neutrophil activation assay which measures the frequency CD11b high expression by flow on neutrophils isolated from whole blood</p>
<p>Pembrolizumab pharmacodynamic response in histoculture as measured by IFN gamma signature score</p>
<p>Tumor samples used in flow cytometry analysis, this table the tumor type, pathology, total events and number of CD11b+ cells are shown</p>
<p>A set of 23 anti-LILRB2 antibodies were tested for their ability to block HLA-G tetramer binding LILRB2 and induce TNF alpha in a macrophage activation assay.</p>
<div>Abstract<p>Tumor-associated macrophages (TAM) play an important role in maintaining the immunosuppressive state of tumor microenvironment (TME). High levels CD163<sup>+</sup> TAMs specifically are associated with poor prognosis many solid types. Targeting may represent a key approach development next generation cancer immune therapeutics. Members leukocyte immunoglobulin-like receptor B (LILRB) family, including LILRB2 (ILT4), known to transmit inhibitory signals...
<p>Example gating strategy in vitro differentiated GM-CSF and IL-4 Dendritic Cells</p>
<p>Tumor samples used in flow cytometry analysis, this table the tumor type, pathology, total events and number of CD11b+ cells are shown</p>
<p>Sensitivity of LILRB2 as a predictive biomarker for pharmacodynamic response measured by the macrophage polarization score in histoculture explant cultures.</p>
<p>Example gating strategy in vitro differentiated M-CSF macrophages</p>
<p>A set of 23 anti-LILRB2 antibodies were tested for their ability to block HLA-G tetramer binding LILRB2 and induce TNF alpha in a macrophage activation assay.</p>
<p>A Neutrophil activation assay which measures the frequency CD11b high expression by flow on neutrophils isolated from whole blood</p>