A5041648058- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Neurobiology and Insect Physiology Research
- Impact of Technology on Adolescents
- Digital Mental Health Interventions
- Sleep and related disorders
- Animal Behavior and Reproduction
- Evolution and Genetic Dynamics
- Genetics, Aging, and Longevity in Model Organisms
- Circadian rhythm and melatonin
- Genetic diversity and population structure
- Sleep and Work-Related Fatigue
- Insect and Arachnid Ecology and Behavior
- Plant and animal studies
- Plant Reproductive Biology
- Advanced Technologies in Various Fields
- Insect Resistance and Genetics
- Social Media in Health Education
- Viral Infectious Diseases and Gene Expression in Insects
- Cancer, Hypoxia, and Metabolism
- Spaceflight effects on biology
- Emotion and Mood Recognition
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Data Mining and Machine Learning Applications
- Invertebrate Immune Response Mechanisms
- Behavioral Health and Interventions
University of Oregon
2011-2023
University of Nevada, Reno
2014-2016
University of Southern California
2010-2012
Abstract Background Drosophila melanogaster females show changes in behavior and physiology after mating that are thought to maximize the number of progeny resulting from most recent copulation. Sperm seminal fluid proteins induce post-mating females, however, very little is known about gene expression female head central nervous system tissues contribute response. Results We determined temporal 0-2, 24, 48 72 hours mating. Females each time point had a unique response, with having largest...
Feeding state and food availability can dramatically alter an animals' sensory response to chemicals in its environment. Dynamic changes the expression of chemoreceptor genes may underlie some these state-dependent chemosensory behavior, but mechanisms underlying are unknown. Here, we identified a KIN-29 (SIK)-dependent chemoreceptor, srh-234, C. elegans whose ADL neuron type is regulated by integration internal feeding signals. We show that addition KIN-29, signaling mediated DAF-2...
Background. Evaluating the social and emotional capabilities of large language models (LLMs), such as their ability to recognize human facial emotion is critical role in human-computer interactions (HCIs) expands, particularly healthcare applications. Facial expressions convey affective clinical information, useful for detecting emotions, contextualizing language, understanding interpersonal dynamics, identifying potential mental health neurocognitive disorders. However, LLMs' accurately...
The metamorphosis of Drosophila melanogaster is accompanied by elimination obsolete neurons via programmed cell death (PCD). Metamorphosis regulated ecdysteroids, including 20-hydroxyecdysone (20E), but the roles and modes action hormones in regulating neuronal PCD are incompletely understood.We used targeted expression GFP to track fate a larval motoneuron, RP2, ventral ganglia. RP2s abdominal neuromeres two through seven (A2 A7) exhibited fragmented DNA 15 hours after puparium formation...
Abstract Long-term memory formation in Drosophila melanogaster is an important neuronal function shaping the insect’s behavioral repertoire by allowing individual to modify behaviors on basis of previous experiences. In conditioned courtship or suppression, male flies that have been repeatedly rejected mated females during advances are less likely than naïve males subsequently court another female. This long-term suppression can last for several days after initial rejection period. Although...
Food and feeding-state dependent changes in chemoreceptor gene expression may allow Caenorhabditis elegans to modify their chemosensory behavior, but the mechanisms essential for these remain poorly characterized. We had previously shown that of a feeding state-dependent gene, srh-234, ADL sensory neuron C. is regulated via MEF-2 transcription factor. Here, we show acts together with basic helix-loop-helix (bHLH) factors regulate srh-234 as function state. identify cis-regulatory MEF2...
The impact of digital device use on health and well-being is a pressing question. However, the scientific literature this topic, to date, marred by small unrepresentative samples, poor measurement core constructs, limited ability address psychological behavioral mechanisms that may underlie relationships between well-being. Recent authoritative reviews have made urgent calls for future research projects these limitations. critical role identify which patterns are associated with benefits...
Reducing muscle atrophy following orthopedic surgery is critical during the postoperative period. Our previous work in patients who underwent total knee arthroplasty (TKA) showed that vast majority of occurs within 2 wk and essential amino acid (EAA) supplementation attenuates this atrophy. We used RNA-sequencing (RNA-seq) to identify genes associated with after TKA without EAAs. Analysis overrepresented gene-ontology terms revealed p53 signaling cytokine-cytokine receptor pathways were...
Meiotic recombination is a critical process that ensures proper segregation of chromosome homologs through DNA double-strand break repair mechanisms. Rates are highly variable among various taxa, within species, and genomes with far-reaching evolutionary genomic consequences. The genetic basis rate variation therefore crucial in the study biology but remains poorly understood. In this study, we took advantage set experimental temperature-evolved populations Drosophila melanogaster heritable...
Abstract Introduction The Digital Wellbeing Study is an IRB approved joint study between the University of Oregon and Google to investigate how smartphone usage interacts with objective subjective parameters well-being such as sleep, exercise stress. recruited a demographically diverse population who each wore smartwatch installed app linked study. Participants completed demographic health questionnaires including PROMIS Sleep Disturbance (SD) Short Form. Aims included (a) whether sleep...
Abstract Introduction Wearables offer scalable, passive and objective measures of sleep, but how well do they capture feelings sleep disturbance impairment? We studied a large, diverse group (n=2992 adults) using wearables compared metrics to self-reported impairment. Methods Participants in the Digital Wellbeing Study wore one several wearable devices (Fitbit) capable tracking such as Total Sleep Time (TST), bedtime, wake-up time, estimated stage durations etc. over 4-week period under...
Abstract Electrodermal activity (EDA) is a measure of sympathetic arousal that has been linked to depression in laboratory experiments. However, the inability EDA passively over time and real-world limited conclusions can be drawn about as an indicator mental health status outside controlled settings. Recent smartwatches have begun incorporate wrist-worn continuous sensors enable longitudinal measurement every-day life. This work (N=237, 4-week observation period) examines association...
<sec> <title>BACKGROUND</title> The impact of digital device use on health and well-being is a pressing question. However, the scientific literature this topic, to date, marred by small unrepresentative samples, poor measurement core constructs, limited ability address psychological behavioral mechanisms that may underlie relationships between well-being. Recent authoritative reviews have made urgent calls for future research projects these limitations. critical role identify which patterns...
The impact of digital device use on health and well-being is a pressing question to which individuals, families, schools, policy makers, legislators, designers are all demanding answers. However, the scientific literature this topic date marred by small and/or unrepresentative samples, poor measurement core constructs (e.g., use, smartphone addiction), limited ability address psychological behavioral mechanisms that may underlie relationships between well-being. A number recent authoritative...
Abstract Meiotic recombination plays a critical evolutionary role in maintaining fitness response to selective pressures due changing environments. Variation rate has been observed amongst and between species populations within genomes across numerous taxa. Studies have demonstrated link changes selection, but the extent which fine-scale varies evolved during period selection is under active research. Here, we utilize set of 3 temperature-evolved Drosophila melanogaster that were shown...
Abstract Meiotic recombination plays a critical evolutionary role in maintaining fitness response to selective pressures due changing environments. Variation rate has been observed amongst and between species populations within genomes across numerous taxa. Studies have demonstrated link changes selection but the extent which fine scale varies evolved during period is under active research. Here we utilize set of three temperature-evolved Drosophila melanogaster that were shown diverged...