A5014709522- Mesenchymal stem cell research
- Bone Tissue Engineering Materials
- Sarcoma Diagnosis and Treatment
- Bone Tumor Diagnosis and Treatments
- Cardiac Arrest and Resuscitation
- Orthopedic Surgery and Rehabilitation
- Bone fractures and treatments
- Musculoskeletal synovial abnormalities and treatments
- Orthopaedic implants and arthroplasty
- Tissue Engineering and Regenerative Medicine
- Elbow and Forearm Trauma Treatment
- Periodontal Regeneration and Treatments
- Carcinogens and Genotoxicity Assessment
- Reconstructive Surgery and Microvascular Techniques
- Emergency and Acute Care Studies
- Toxic Organic Pollutants Impact
- Oral and Maxillofacial Pathology
- Trauma and Emergency Care Studies
- Food Safety and Hygiene
- Identification and Quantification in Food
- Disaster Response and Management
- Radiation Dose and Imaging
- RNA Interference and Gene Delivery
- Health, Environment, Cognitive Aging
- Dental Implant Techniques and Outcomes
National Institute of Public Health
2020-2025
Nara Medical University
2014-2024
Shimane University
2024
Nara Medical University Hospital
2001-2018
The University of Tokyo
2011-2013
University of Tokyo Hospital
2011-2012
Nippon Medical School
2012
University hospital Medical Information Network
2009
National Cancer Institute
2004-2005
National Institutes of Health
2004-2005
Background: Recent clinical studies have suggested that denosumab is associated with tumor response and reduced surgical morbidity in patients giant-cell of bone (GCTB). We therefore evaluated the recurrence-free survival rate who had GCTB an extremity were treated surgery denosumab, to determine influence factors on risk local recurrence. Methods: retrospectively reviewed medical records 408 for a single institution from 1990 through 2013. Two hundred forty-seven underwent curettage...
Osteocalcin (OC) is a bone-specific protein synthesized by osteoblasts that represents good marker for osteogenic maturation. We examined whether in vitro differentiation of rat bone marrow-derived mesenchymal stem cells (MSCs) could be simply assessed at earlier stages monitoring OC secretion into the conditioned medium, rather than measuring deposition on extracellular matrix (ECM), using sandwich enzyme immunoassay system involving specific anti-rat monoclonal antibody. During 16-day...
<b>Objective</b> To compare the effectiveness of cardiopulmonary resuscitation (CPR) with chest compression only and conventional CPR on outcomes after arrest out hospital. <b>Design</b> Nationwide population based observational study. <b>Setting</b> A nationwide emergency medical service system in Japan. <b>Population</b> All consecutive patients hospital arrest, January 2005 to December 2007 Japan, witnessed at moment collapse. Lay people attempted (n=20 707) or (mouth mouth ventilation...
We previously reported that in vivo bone formation could be observed composites of porous hydroxyapatite (HA) scaffolds and cultured mesenchymal stem cells (MSCs). In the present study, we developed a new method for transplantation MSCs without necessity using scaffold to form tissue. were culture-expanded lifted as cell sheet structures. These sheets, designated osteogenic matrix showed positive alkaline phosphatase (ALP) staining, high ALP activities osteocalcin (OC) contents, indicating...
Little is known about the effects of geographic variation on outcomes out-of-hospital cardiac arrest (OHCA). The present study investigated relationship between population density, time emergency call and ambulance arrival, survival OHCA, using All-Japan Utstein-style registry database, coupled with information system (GIS) data.We examined data from 101,287 bystander-witnessed OHCA patients who received medical services (EMS) through 4,729 ambulatory centers in Japan 2005 2007. Latitudes...
Most previous studies of pediatric out-of-hospital cardiac arrest have typically examined relatively small datasets from study regions. Although several reported the impact on adult arrest, little information is available telephone dispatcher assistance outcomes arrest. We set out to examine cardiopulmonary resuscitation instruction by arrest.Population-based, observational study.Japan-wide population-based setting.We identified 1,780 patients (67.8% male) with witnessed collapse a...
Abstract Introduction There are inconsistent data about the effectiveness of prehospital physician-staffed advanced cardiac life support (ACLS) on outcomes out-of-hospital arrest (OHCA). Furthermore, relative importance bystander-initiated cardiopulmonary resuscitation (BCPR) and ACLS their combination have not been clearly demonstrated. Methods Using a prospective, nationwide, population-based registry all OHCA patients in Japan, we enrolled 95,072 whose arrests were witnessed by bystanders...
Objectives: There is a paucity of data examining nationwide population-based incidences and outcomes pediatric out-of-hospital cardiac arrest. The objective this study to describe the detailed characteristics arrest by scholastic age category evaluate impact bystander cardiopulmonary resuscitation public access–automated external defibrillators on 1-month survival favorable neurological status patients. Design: A nationwide, population-based, observational study. Setting: Nationwide...
OBJECTIVE Transplantation of bone marrow stromal cells (BMSCs) is a theoretical potential as therapeutic strategy in the treatment spinal cord injury (SCI). Although scaffold sometimes used for retaining transplanted damaged tissue, it also known to induce redundant immunoreactions during degradation processes. In this study, authors prepared cell sheets made BMSCs, which are transplantable without scaffold, and investigated their effects on axonal regeneration, glial scar formation,...
We previously reported a new cell transplantation method in which mesenchymal stem cells (MSCs) were cultured as sheets. The MSC sheets showed high alkaline phosphatase (ALP) activities and osteocalcin (OC) contents. In the present study, we transplanted such by injection to assess whether injectable could form bone tissue at subcutaneous sites. At 4 weeks after injection, injected areas hard mass formation. Each consisted of newly formed bone, evaluated radiographic, histological gene...
Although the tangential sesamoid view is used to visualize position relative first metatarsal head, correctly evaluating patients with severe varus of difficult. Computed tomography (CT) can be helpful due its cross-sectional images in any plane. The purposes this study were evaluate alignment tibial and investigate relationship between malalignment degenerative change joint (SMJ) using simulated weight-bearing CT imaging hallux valgus.In total, 269 feet from 142 valgus included. mean age...
Once ingested, dioxins and dioxin-like compounds are excreted extremely slowly. Excretion can be evaluated by its half-life. Half-lives estimated from observed concentrations affected excretion ongoing exposure. We investigated the change in apparent half-life using a theoretical model based on exposure to dioxin compounds.We carried out longitudinal measurements of blood concentration Yusho cohort during 2002 2010. decay rates 2,3,4,7,8-PeCDF octachlorodibenzodioxin (OCDD) second-order...
Introduction : Dedifferentiated chondrosarcoma (DDCS) is a high-grade subtype of with poor prognosis. Treatment for localized DDCS generally involves wide resection; the effectiveness adjuvant radiotherapy and chemotherapy questionable. This research was designed to find prognostic factors evaluate impact therapies on cases. Methods One hundred thirty-two patients diagnosed by pathology in period 2006 2022 were identified Japanese National Bone Soft Tissue Tumor Registry database...
We investigated the in vivo osteogenic ability of cultured marrow cells subcultured porous hydroxyapatite. This was compared with that cancellous bone grafts. Fresh were obtained from young adult rat femora and a standard medium for 10 days, then trypsinized used to make constructs hydroxyapatite (HA) cells. An additional 2-week culture (subculture) performed construct without addition dexamethasone (Dex). The implanted into subcutaneous sites syngeneic rats. These implants harvested...