A5051630199- Lymphatic System and Diseases
- Vascular Tumors and Angiosarcomas
- Vascular Malformations and Hemangiomas
- Immune cells in cancer
- Biomarkers in Disease Mechanisms
- Angiogenesis and VEGF in Cancer
- Nitric Oxide and Endothelin Effects
- Kruppel-like factors research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Sympathectomy and Hyperhidrosis Treatments
- RNA regulation and disease
- RNA Research and Splicing
- CRISPR and Genetic Engineering
- Cancer Mechanisms and Therapy
- Cell Adhesion Molecules Research
- interferon and immune responses
- Ubiquitin and proteasome pathways
- RNA Interference and Gene Delivery
- Viral Infections and Outbreaks Research
- Cancer Diagnosis and Treatment
- Signaling Pathways in Disease
- Prostate Cancer Treatment and Research
University of California, San Diego
2020-2021
Sanford Consortium for Regenerative Medicine
2020
University of Lausanne
2014-2019
Ludwig Cancer Research
2019
University Hospital of Lausanne
2014-2015
Monash University
2011-2012
Monash Institute of Medical Research
2011-2012
Hudson Institute
2009
Significance Tumor recognition by the immune system can occur spontaneously but has usually little impact on tumor growth. However, cellular and molecular mechanisms that drive these responses could be exploited therapeutically to generate efficacious antitumor immunity. Here, we show stimulator of IFN genes (STING), a molecule involved in cytosolic DNA sensing required for generation spontaneous responses, targeted intratumoral injection cGAMP boost immunity control The response induced...
Background Dysfunctional lymphatic vessel formation has been implicated in a number of pathological conditions including cancer metastasis, lymphedema, and impaired wound healing. The vascular endothelial growth factor (VEGF) family is major regulator cell (LEC) function lymphangiogenesis. Indeed, dissemination malignant cells into the regional lymph nodes, common occurrence many cancers, stimulated by VEGF members. This effect generally considered to be mediated via VEGFR-2 VEGFR-3....
Inflammation-dependent base deaminases promote therapeutic resistance in many malignancies. However, their roles human pre-leukemia stem cell (pre-LSC) evolution to acute myeloid leukemia cells (LSCs) had not been elucidated. Comparative whole-genome and whole-transcriptome sequencing analyses of FACS-purified pre-LSCs from myeloproliferative neoplasm (MPN) patients reveal APOBEC3C upregulation, an increased C-to-T mutational burden, hematopoietic progenitor (HSPC) proliferation during...
Prostate cancer disseminates to regional lymph nodes, however the molecular mechanisms responsible for node metastasis are poorly understood. The vascular endothelial growth factor (VEGF) ligand and receptor family have been implicated in spread of prostate via activation blood vasculature lymphatic systems. purpose this study was comprehensively examine expression pattern VEGF ligands receptors glandular epithelium, stroma, vessels cancer.The localization VEGF-A, VEGF-C, VEGF-D, (VEGFR)-1,...
Calcineurin/NFAT signaling is active in endothelial cells and proposed to be an essential component of the tumor angiogenic response. Here, we investigated role calcineurin vivo physiological pathological angiogenesis metastasis. We show that this pathway dispensable for retinal angiogenesis, but it implicated vessel stabilization. While ablation does not affect progression primary tumors or cell extravasation, potentiate outgrowth lung metastases. identify Bmp2 as a downstream target...
Abstract Introduction: Lymphangiogenesis (growth of nascent lymphatic vessels in vivo and proliferation, migration tube formation endothelial cells (LECs) vitro) plays a key role lymph node metastasis number tumour types (1), including prostate cancer. Mechanisms underlying tumor cell-lymphatic vessel interactions are critical to understand. Thus determining the molecular basis LEC motility its relationship lymphangiogenesis subsequent will play an important part developing novel strategies...
Abstract Dissemination of malignant cells into the regional lymph nodes is a common occurrence in many cancers. The vascular endothelial growth factor (VEGF) family major regulator spread cancer to via induction lymphangiogenesis. We have used primary lymphatic and clinical material investigate VEGF-C/VEGF receptor (VEGFR)-3 signalling pathways. found that treatment with VEGF-C induced activation PI3K/Akt MEK/Erk cells. Furthermore, by VEGF-C/VEGFR-3 resulted phosphorylation P70S6K, eNOS,...