A5005477835- Histone Deacetylase Inhibitors Research
- Protein Degradation and Inhibitors
- Epigenetics and DNA Methylation
- Chromatin Remodeling and Cancer
- Glioma Diagnosis and Treatment
- RNA modifications and cancer
- Cancer-related gene regulation
- Molecular Biology Techniques and Applications
- RNA and protein synthesis mechanisms
- Angiogenesis and VEGF in Cancer
- Neuroblastoma Research and Treatments
- Marine Sponges and Natural Products
- ATP Synthase and ATPases Research
- Phagocytosis and Immune Regulation
- Adenosine and Purinergic Signaling
- CRISPR and Genetic Engineering
- Inflammasome and immune disorders
- Genomics and Phylogenetic Studies
- Genomics and Chromatin Dynamics
- Sympathectomy and Hyperhidrosis Treatments
- Vanadium and Halogenation Chemistry
- Peptidase Inhibition and Analysis
- Genetics and Neurodevelopmental Disorders
- Cancer-related Molecular Pathways
- Lymphatic System and Diseases
Monash University
2011-2023
Hudson Institute of Medical Research
2016-2023
Monash Institute of Medical Research
2011-2014
Data61
2012
The University of Melbourne
2012
Abstract Motivation: Shotgun sequence read data derived from xenograft material contains a mixture of reads arising the host and graft. Classifying to separate two allows for more precise analysis be performed. Results: We present technique, with an associated tool Xenome, which performs fast, accurate specific classification xenograft-derived data. have evaluated it on RNA-Seq human, mouse human-in-mouse datasets. Availability: Xenome is available non-commercial use...
Aberrant activation of Wnt/β-catenin pathway is a key driver colorectal cancer (CRC) growth and great therapeutic importance. In this study, we performed comprehensive CRISPR screens to interrogate the regulatory network signaling in CRC cells. We found marked discrepancies between artificial TOP reporter activity β-catenin-mediated endogenous transcription redundant roles T cell factor/lymphoid enhancer factor factors transducing β-catenin signaling. Compiled functional genomic analysis...
Initiation and maintenance of transcriptional states are critical for controlling normal tissue homeostasis differentiation. The cyclin dependent kinases CDK8 CDK19 (Mediator kinases) regulatory components Mediator, a highly conserved complex that orchestrates enhancer-mediated output. While Mediator have been implicated in the transcription genes necessary development growth, its function mammals has not well defined. Using genetically defined models pharmacological inhibitors, we showed...
Improved treatment strategies are required for bladder cancer due to frequent recurrence of low-grade tumors and poor survival rate from high-grade with current therapies. Histone deacetylase inhibitors (HDACi), approved as single agents specific lymphomas, have shown promising preclinical results in solid but could benefit identification biomarkers response. Loss activating transcription factor 3 (ATF3) expression is a feature tumor progression correlates survival. We investigated the...
Here we investigate the function of innate immune molecule protein kinase R (PKR) in intestinal inflammation. To model a colitogenic role PKR, determine physiological response to dextran sulfate sodium (DSS) wild-type and two transgenic mice strains mutated express either kinase-dead PKR or ablate expression kinase. These experiments recognize kinase-dependent -independent protection from DSS-induced weight loss inflammation, against increase susceptibility injury. We propose these effects...
Abstract Cell lines represent the most versatile and widely used models of cancer and, as such, are critical for identifying advancing new therapies. Strikingly, there is a significant gap in both number childhood brain cell their characterisation compared to adult counterparts. To address this inequity, we established line atlas (publicly available at vicpcc.org.au/dashboard) encompassing over 180 CNS-derived lines, representing 20 tumour types 11 molecular subtypes. characterized by whole...
Abstract BACKGROUND: Bladder cancer is the fifth most common affecting Western world. About 90% of bladder superficial and remaining 10% muscle invasive. Surgery followed by platinum based chemotherapy standard treatment for high grade tumors, results in <50% 5 year survival rate following surgery. ATF3 can play a key role as either an oncogenic suppressor or inducer depending on degree malignancy. Decreased expression has been associated with tumor progression reduced [1]....
<p>Figure S1. Pracinostat reactivates acetylation of non-histone protein tubulin at higher doses. Figure S2. Alteration in malignant behavior cancer cell lines vitro with treatment. S3. ATF3 regulates the transcriptional activation RB1. S4. treatment inhibits vivo tumor growth. S5. production proangiogenic factor VEGF- A vitro. S6. reactivation is crucial determining sensitivity HDACi bladder cancer. S7. The level expression HDAC enzymes may dictate degree different Supplementary...
<p>Figure S1. Pracinostat reactivates acetylation of non-histone protein tubulin at higher doses. Figure S2. Alteration in malignant behavior cancer cell lines vitro with treatment. S3. ATF3 regulates the transcriptional activation RB1. S4. treatment inhibits vivo tumor growth. S5. production proangiogenic factor VEGF- A vitro. S6. reactivation is crucial determining sensitivity HDACi bladder cancer. S7. The level expression HDAC enzymes may dictate degree different Supplementary...
<div>Abstract<p>Improved treatment strategies are required for bladder cancer due to frequent recurrence of low-grade tumors and poor survival rate from high-grade with current therapies. Histone deacetylase inhibitors (HDACi), approved as single agents specific lymphomas, have shown promising preclinical results in solid but could benefit identification biomarkers response. Loss activating transcription factor 3 (ATF3) expression is a feature tumor progression correlates...
<div>Abstract<p>Improved treatment strategies are required for bladder cancer due to frequent recurrence of low-grade tumors and poor survival rate from high-grade with current therapies. Histone deacetylase inhibitors (HDACi), approved as single agents specific lymphomas, have shown promising preclinical results in solid but could benefit identification biomarkers response. Loss activating transcription factor 3 (ATF3) expression is a feature tumor progression correlates...
Abstract Atypical teratoid rhabdoid tumours (ATRTs) are high-grade malignant paediatric brain with a less than one-year survival rate after diagnosis. Current treatment for ATRT, which includes high-intensive radiotherapy and chemotherapy, results in long-term side effects on ATRT patients. Hence, there is an urgent need to discover targeted therapies that could be used treat patients ATRT. As part of the Hudson Monash Paediatric Precision Medicine Program, we have collected 23 cell lines...
Abstract The precise decoding of human genomes facilitated by the advancements in next-generation sequencing has led to a better understanding genetic underpinnings pediatric brain cancers. Indeed, it is now evident that tumours same type harbour distinct driving mutations and molecular aberrations can result different prognosis treatment outcomes. profounder insight into identity, amount types paved way for advent targeted therapies precision medicine. Nevertheless, less than 10% cancer...