Abstract Background Alignment of RNA secondary structures is important in studying functional motifs. In recent years, much progress has been made motif finding and structure alignment. However, existing tools either require a large number prealigned or suffer from high time complexities. This makes it difficult for the to process RNAs whose are unavailable very databases. Results We present here an efficient tool called RSmatch aligning detection. Motivated by widely used algorithms...

Background: Salvianolic acid B (Sal B) is one of the main active ingredients Sa lvia miltiorrhiza Bunge . In China, many traditional Chinese medicines have been modified into injections for higher bioavailability and better efficacy. injection has widely used in clinic. Objective: This phase 1, randomized, double-blind, placebo-controlled, single-center study aimed to evaluate safety, tolerance, pharmacokinetics Sal healthy volunteers. Methods: For single-ascending-dose study, forty-seven...

Abstract It has been demonstrated that many promising thermoelectric materials, such as tetradymite compounds are also three-dimensional topological insulators. In both cases, a fundamental question is the evaluation of carrier relaxation time, which usually rough task due to complicated scattering mechanisms. Previous works using simple deformation potential theory or considering complete electron-phonon coupling are, however, restricted small systems. By adopting data-driven method named...

XML is increasingly important in data exchange and information management. A large amount of efforts have been spent developing efficient techniques for storing, querying, indexing accessing documents. In This work we propose a new approach to clustering data. contrast previous work, which focused on documents defined by different DTDs, the proposed method works with same DTD. Our extract features from documents, modeled ordered labeled trees, transform vectors high-dimensional Euclidean...

UnTranslated Regions (UTRs) of mRNAs contain regulatory elements for various aspects mRNA metabolism, such as localization, translation, and stability. Several RNA stem-loop structures in UTRs have been experimentally identified, including the histone 3' UTR structure (HSL3) iron response element (IRE). These are conserved among mammalian orthologs, exist a group genes encoding proteins involved same biological pathways. It is not known to what extent like these all UTRs.In this paper we...

The further integration of emerging technologies such as artificial intelligence (AI), mobile edge computing (MEC), blockchain, have recently emerged a powerful weapon with the Internet Things (IoT). A data-centric IoT network is particularly important for ensuring data and privacy security. Based on this, this paper proposes secure framework that integrates these to enable system work efficiently. With transformation IoT, puts forward higher requirements rate support real-time reliable...

Cloud computing is a new way of data storage, where users tend to upload video cloud servers without redundantly local copies. However, it keeps the out users' hands which would conventionally control and manage data. Therefore, becomes key issue on how ensure integrity reliability stored in for provision streaming services end users. This paper details verification methods encrypted using fully homomorphic crytosystems context computing. Specifically, we apply dynamic operation with method...

XML is increasingly important in data exchange and information management. A great deal of efforts have been spent developing efficient techniques for storing, querying, indexing accessing documents. In this paper we propose a new approach to clustering data. contrast previous work, which focused on documents defined by different DTDs, the proposed method works with same DTD. Our extract features from documents, modeled ordered labeled trees, transform vectors high-dimensional Euclidean...

Rv3899c, a hypothetical protein from Mycobacterium tuberculosis that is conserved within the mycobacteria, predicted to be secreted and has been found in culture filtrates. Here, Rv3899c cloned, expressed Escherichia coli purified using standard chromatographic techniques. The hanging-drop vapour-diffusion method with PEG 3350 as precipitant was used crystallize protein. N-terminal sequencing results showed amino-acid sequence of crystallized began GATAG, indicating it fragment containing...

Abstract To assess the bioequivalence of two 5‐mg olanzapine orally disintegrating tablet (ODT) products, 2 randomized, open‐label, single‐dose, 2‐way crossover studies were carried out under fasting or fed conditions. Blood samples collected at scheduled times according to study protocol. Statistical analysis area concentration‐time curve from time 0 168 hours (AUC 0‐t ), zero infinity 0‐∞ and peak plasma concentration (C max ) was conducted. Two formulations considered bioequivalent if 90%...

The side effects and drug resistance during chemotherapy seriously affect the outcome of may lead to failure for patients with hepatoma. aim present study was investigate association between expression ATP-binding cassette transporter G2 (ABCG2) in hepatoma cells An MTT assay used determine half-maximal inhibitory concentration (IC50) Adriamycin (ADM) HepG2 after treatment ADM 24 h. ADM-resistant cell subline, HepG2/ADM, generated from line through a stepwise selection doses 0.01 0.1 µg/ml....

Cinitapride (CIN) is a drug for functional dyspepsia. The purpose of the study was to investigate pharmacokinetics and tolerability CIN in healthy Chinese volunteers. A randomized, open-label, single- multiple-dose conducted 12 Three different doses (1, 2, 4 tablets) were given six groups single-dose study, one tablet (1 mg) administered three times day study. Blood samples collected at predetermined time intervals after dosing analyzed by LC-MS/MS. Eleven volunteers completed After single...

This study proposes an improved speech assessment algorithm and English (as a foreign language in China) system based on robust recognition to assess learners' pronunciation more accurately noisy environments. In this paper, the traditional framework of is studied by literature analysis method survey research method. At same time, principle are further studied. Furthermore, feature compensation Vector Taylor Series (VTS) developed. Finally, developed analysed perceptual quality (PESQ) mean...