Computer-aided drug design (CADD) often involves virtual screening (VS) of large compound datasets and the availability such is vital for discovery protocols. We assess bioactivity "drug-likeness" a relatively small but structurally diverse dataset (containing >1,000 compounds) from African medicinal plants, which have been tested proven wide range biological activities. The geographical regions collection plants cover entire continent Africa, based on data literature sources information...

Computer-aided drug design (CADD) often involves virtual screening (VS) of large compound datasets and the availability such is vital for discovery protocols. We present CamMedNP - a new database beginning with more than 2,500 compounds natural origin, along some their derivatives which were obtained through hemisynthesis. These are pure have been previously isolated characterized using modern spectroscopic methods published by several research teams spread across Cameroon. In study, 224...

Malaria is an endemic disease affecting many countries in Tropical regions. In the search for compound hits design and/or development of new drugs against disease, research teams have resorted to African medicinal plants order identify lead compounds. Three-dimensional molecular models were generated anti-malarial compounds origin (from 'weakly' active 'highly' active), which identified from literature sources. Selected computed descriptors related absorption, distribution, metabolism,...

Onchocerciasis caused by Onchocerca volvulus is the world’s second leading infectious cause of blindness. There currently no cure for disease. Ivermectin, current drug choice only microfilaricidal and suboptimal response to it increasingly being reported. Thus, in contributing search a cure, crude extracts chromatographic fractions Craterispermum laurinum Morinda lucida were screened vitro, against bovine most popular model parasite, ochengi. Extracted parasites cultured RPMI-1640 based...

The lack of a safe and effective adult worm drug the emergence resistant animal parasite strains to only recommended drug, microfilaricide, ivermectin put many at risk devastating effects onchocerciasis. present study was undertaken investigate acclaimed anti-Onchocerca activity roots/rhizomes Cyperus articulatus in traditional treatment onchocerciasis North Western Cameroon assess plant as new source potential filaricidal lead compounds. Crude extracts were prepared from dried parts using...

Abstract Background The global burden of bacterial infections is high and has been further aggravated by increasing resistance to antibiotics. In the search for novel antibacterials, three medicinal plants: Peperomia vulcanica, fernandopoioana (Piperaceae) Scleria striatinux (Cyperaceae), were investigated antibacterial activity toxicity. Methods Crude extracts these plants tested disc diffusion method against six test organisms followed bio-assay guided fractionation, isolation testing pure...

Drug metabolism and pharmacokinetic (DMPK) assessment has come to occupy a place of interest during the early stages drug discovery today. Computer-based methods are slowly gaining ground in this area often used as initial tools eliminate compounds likely present uninteresting profiles unacceptable levels toxicity from list potential candidates, hence cutting down cost drug. In study, we an silico DMPK profile our recently published natural products database 1,859 unique derived 224 species...

Onchocerciasis is the world's second leading infectious cause of blindness. Its control currently hampered by lack a macrofilaricidal drug and severe adverse events observed when lone recommended microfilaricide, ivermectin administered to individuals co-infected with Loa loa. Therefore, there need for safe effective that will be able cure infection break transmission cycles, or at least, an alternative microfilaricide does not kill L. loa microfilariae (mf). Fourteen extracts from two...

We screened forty crude extracts of twenty Cameroonian medicinal plants commonly used to treat bacterial infections for broad spectrum antibacterial activity, as a more affordable alternative against resistant organisms. The were on common pathogenic gram negative and positive bacteria initially by the disc diffusion method followed tube dilution method. Using discs containing 30µg extract, Escherichia coli showed sensitivity 23 with diameter zone inhibition ranging from 7 – 19mm, fifteen...

Okundoperoxide (1) was isolated by bioassay-guided fractionation of extracts from Scleria striatinux (syn. S. striatonux). The compound contains a cyclic endoperoxide structural moiety and possesses moderate antimalarial activity.

The aims of this investigation were to isolate active ingredients from the roots/rhizomes Cyperus articulatus used as herbal medicine in Cameroon for treatment human onchocerciasis and assess efficacy metabolites on Onchocerca worm. antifilarial activity was evaluated vitro microfilariae (Mfs) adult worms bovine derived ochengi, a close relative volvulus. Cytotoxicity assessed monkey kidney epithelial cells. structures compounds determined using spectroscopic methods their drug-likeness...

A phytochemical study of the methylene chloride/methanol (1/1) extract leaves Glossocalyx brevipes Benth. (Monimiaceae) afforded three new derivatives homogentisic acid, methyl 2-(1′β-geranyl-5′β-hydroxy-2′-oxocyclohex-3′-enyl)acetate (1), 2-(1′β-geranyl-5′β-hydroxy-2′-oxocyclohex-3′-enyl)acetic acid (2), 2-(1′β-geranyl-5′β-hydroxy-4′β-methoxy-2′-oxocyclohexyl)acetate (3), and two known alkaloids, aristololactam BII liriodenine. Compounds 1 2 liriodenine showed modest in vitro activity...

A new iboga-vobasine-type isomeric bisindole alkaloid named voacamine (1), along with eight known compounds—voacangine (2), voacristine (3), coronaridine (4), tabernanthine (5), iboxygaine (6), (7), voacorine (8) and conoduramine (9)—were isolated from the stem bark of Voacangaafricana. The structures compounds were determined by comprehensive spectroscopic analyses. Compounds 1, 2, 3, 4, 6, 7 8 found to inhibit motility both microfilariae (Mf) adult male worms Onchocerca ochengi, in a...

This review is intended to highlight the relevance of natural products in drug discovery paying particular attention those derived from Southern African medicinal plants with diverse biological activities.

Chemical investigation of the leaves Manniophyton fulvum led to isolation seven flavonoid glycosides: myricetin-3-O-β-Dd-rhamnoside (1), kaempferol-3-O-β-d-rhamnoside (2), quercetin-3-O-β-d-glucoside (3), quercetin-3-O-β-d-rhamnoside (4), quercetin-3-O-β-d-galactoside (5), rutin (6) and quercetin (7). The structures compounds were established by spectroscopic analyses as well comparison with published data. Some showed strong antioxidant activity which validates traditional use plant. An...

Aims :This study investigated the antiplasmodial activity of crude extracts, fractions and pure isolates ofP. vulcanicaand P. fernandopoioana(Piperaceae). Toxicity interaction between most active natural products were also assessed. Study Design: Bioassay-guided approach was used to identify further investigate components against chloroquine -sensitive resistant falciparumstrains. Place Duration Study:Departments Biochemistry Molecular Biology, Chemistry Biotechnology Unit, Faculty Science,...

A novel ligand, 1-(4-methoxybenzylidene)-4-methylthiosemicarbazone (MBT) derived from 4-methoxybenzaldehyde was synthesized and characterized by spectroscopic methods (IR, 1H NMR, 13C NMR), single crystal X-ray diffraction technique physical means. MBT showed antibacterial activity in vitro with MICs of 64 μg/mL (a strain Salmonella typhi (ATCC 6539)), 128 (Salmonella typhi), paratyphi A), B) typhimurium). The results that demonstrated moderate against a 6539), A, typhimurium, indicating its...

As a whole, the African continent is highly endowed with huge floral biodiversity.

Scleria striatonux (Cyperaceae), a spice traditionally used in Cameroon, displayed an antiplasmodial activity. Two new sesquiterpenes, 1 (sclerienone A) and 2 B), have subsequently been isolated from the methylene chloride/methanol extract of rhizome. Their separation involved combination methods including repeated silica gel open column chromatography, Sephadex LH-20 semi-preparative HPLC. Structure elucidation was achieved by means chemical tests extensive spectral studies.