A5058950442- Acute Myeloid Leukemia Research
- RNA Research and Splicing
- MicroRNA in disease regulation
- RNA Interference and Gene Delivery
- Neuroscience and Neural Engineering
- Ion channel regulation and function
- Anodic Oxide Films and Nanostructures
- Hedgehog Signaling Pathway Studies
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Hematopoietic Stem Cell Transplantation
- Advanced biosensing and bioanalysis techniques
- Cardiac electrophysiology and arrhythmias
- Circular RNAs in diseases
- Epigenetics and DNA Methylation
Martin Luther University Halle-Wittenberg
2019-2021
MicroRNAs (miRs) contribute to different aspects of cardiovascular pathology, among others cardiac hypertrophy and atrial fibrillation. The aim our study was evaluate the impact miR-221/222 on electrical remodeling. Cardiac miR expression analyzed in a mouse model with altered electrocardiography parameters severe heart hypertrophy. Next generation sequencing revealed 14 differentially expressed miRs hypertrophic hearts, miR-221 -222 being strongest regulated miR-cluster. This increase...
MicroRNAs (miRs) contribute to different aspects of cardiovascular pathology, among them cardiac hypertrophy and atrial fibrillation. Cardiac miR expression was analyzed in a mouse model with structural electrical remodeling. Next-generation sequencing revealed that miR-208b-3p ~25-fold upregulated. Therefore, the aim our study evaluate impact miR-208b on protein expression. First, an undirected approach comparing whole RNA data miR-walk 2.0 3'-UTR targets 58 potential being regulated. We...
Abstract Background Cardiovascular disease is the leading cause of death worldwide. Cardiac electrical remodeling including altered ion channel expression and imbalance calcium homeostasis can have detrimental effects on cardiac function. While it has been extensively reported that miR-221/222 are involved in structural remodeling, their role still to be evaluated. We previously subunits L-type Ca 2+ (LTCC) direct targets miR-221/222. Furthermore, HL-1 cells transfected with miR-221 or -222...
7042 Background: Surface antigen expression evaluation is part of the standard work-up at acute myeloid leukemia (AML) diagnosis. The biological & prognostic implications surface patterns in normal karyotype (NK) AML patients (pts) remain unknown. Methods: diagnostic mononuclear cells bone marrow (BM) 111 NK-AML pts were assessed using a flow cytometric panel. At diagnosis common gene mutations (mut) levels analyzed. Pts received stem cell transplantation (SCT, 98% allogeneic, 2%...