A5070626119- Advanced Chemical Sensor Technologies
- Olfactory and Sensory Function Studies
- Shoulder and Clavicle Injuries
- Metabolomics and Mass Spectrometry Studies
- Muscle and Compartmental Disorders
- Trauma Management and Diagnosis
- Pelvic and Acetabular Injuries
- Respiratory Support and Mechanisms
- Shoulder Injury and Treatment
- Antimicrobial Resistance in Staphylococcus
- Advanced X-ray Imaging Techniques
- Management of metastatic bone disease
- Inhalation and Respiratory Drug Delivery
- Mass Spectrometry Techniques and Applications
- X-ray Spectroscopy and Fluorescence Analysis
- Surgical Sutures and Adhesives
- Bacterial Identification and Susceptibility Testing
- Dialysis and Renal Disease Management
- Cardiovascular Health and Disease Prevention
- Hip disorders and treatments
- Renal function and acid-base balance
- Neurological and metabolic disorders
- Biochemical Analysis and Sensing Techniques
- Acute Kidney Injury Research
- Foot and Ankle Surgery
Saarland University
2014-2023
Universitätsklinikum des Saarlandes
2021
Max Planck Institute for Informatics
2014
University of Freiburg
2009
Chirurgische Universitätsklinik Heidelberg
1981
University of Münster
1978-1980
<b><i>Introduction:</i></b> Rhabdomyolysis is characterized by destruction of muscle fibers various causes and diagnosed increased creatine kinase concentrations in the blood. Myoglobin released into blood may cause acute kidney injury. In this randomized controlled study, we hypothesized that myoglobin elimination would be faster when a hemoadsorber was added to continuous veno-venous hemodialysis (CVVHD). <b><i>Methods:</i></b> Four patients...
Multicapillary column ion-mobility spectrometry (MCC-IMS) may identify volatile components in exhaled gas. The authors therefore used MCC-IMS to evaluate gas a rat model of sepsis, inflammation, and hemorrhagic shock.Male Sprague-Dawley rats were anesthetized ventilated via tracheostomy for 10 h or until death. Sepsis was induced by cecal ligation incision rats; sham operation performed others. In other rats, endotoxemia intravenous administration mg/kg lipopolysaccharide. final shock mean...
The x-ray dark-field contrast accessible via grating interferometry is sensitive to features at length scales well below what resolvable by a detector system. It commonly explained as arising from small-angle scattering (SAXS), and can be implemented both synchrotron beamlines with low-brilliance sources such tubes. Here, we demonstrate that for tube based setups the underlying process of image formation fundamentally different. For focal spots or pixels comprise multiple periods, show...
Background: This study evaluated the impact of three-dimensional (3D) volume-rendering computed tomography (CT) reconstructions on inter-and intraobserver reliability six commonly used classification systems in assessment calcaneal fractures. Methods: Four independent observers with different levels clinical training 64 fractures according to classifications Orthopaedic Trauma Association (OTA), Essex-Lopresti, Sanders, Crosby, Zwipp, and Regazzoni, using two-dimensional (2D) CT scans...
X-ray grating interferometry is one among various methods that allow extracting the so-called phase and visibility contrasts in addition to well-known transmission images. Crucial achieving a high image quality are absorption gratings employed. Here, we present an in-depth analysis of how type lamella heights influence final Benchmarking two different designs, show frequently used proxy for quality, grating's visibility, insufficient predict contrast-to-noise ratios (CNRs). Presenting scans...
Long-term animal studies are needed to accomplish measurements of volatile organic compounds (VOCs) for medical diagnostics. In order analyze the time course VOCs, it is necessary ventilate these animals. Therefore, a total 10 male Sprague-Dawley rats were anaesthetized and ventilated with synthetic air via tracheotomy 24 h. An ion mobility spectrometry coupled multi-capillary columns (MCC-IMS) was used expired air. To identify background contaminations produced by respirator itself, six...
Breath analysis of rats using multi-capillary column ion-mobility spectrometry (MCC-IMS) revealed alterations in acetone and other ketones, including 3-pentanone, during inflammation. The seem likely to result from oxidative branched-chain keto acid (BCKA) catabolism. We therefore tested the hypothesis that 3-pentanone arises inflammation increased BCKA oxidation liver with consequent accumulation propionyl-CoA its condensation products.
Zusammenfassung Über Mykosen bei Krokodilen ist fast nichts bekannt. Es werden zwei Fälle von beschrieben, die in einem süddeutschen Reptilien-Zoo gehalten wurden. Neben der Anamnese und makroskopischen Symptomatik kulturelle, histologische elektronenmikroskopische Befunde sowie mutmaßlichen Primärnoxen diskutiert. Summary Very little is known about mycoses crocodiles. Two cases of crocodiles, which have been kept a reptilia zoo Southern Germany, are described. The anamneses, the...
Ischemia and reperfusion alter metabolism. Multi-capillary column ion-mobility spectrometry (MCC-IMS) can identify volatile organic compounds (VOCs) in exhaled gas. We therefore used MCC-IMS to evaluate gas a rat model of hemorrhagic shock with reperfusion. Adult male Sprague-Dawley rats (n = 10 control group, n 15 intervention group) were anaesthetized ventilated via tracheostomy for 14 h or until death. Hemorrhagic was maintained 90 min by removing blood from the femoral artery target MAP...
Abstract Background The unrestricted use of linezolid has been linked to the emergence linezolid-resistant Staphylococcus epidermidis (LRSE). We report effects combined antibiotic stewardship and infection control measures on spread LRSE in an intensive care unit (ICU). Methods Microbiological data were reviewed identify all detected clinical samples at ICU southwest Germany. Quantitative antibiotics with Gram-positive coverage obtained defined daily doses (DDD) per 100 patient-days (PD). In...
Systemic inflammation alters the composition of exhaled breath, possibly helping clinicians diagnose conditions such as sepsis. We therefore evaluated changes in breath rats given tumor necrosis factor-alpha (TNF-α). Thirty male Sprague-Dawley were randomly assigned to three groups (n = 10 each) with intravenous injections normal saline (control), 200 µg·kg-1 bodyweight TNF-α (TNF-α-200), or 600 (TNF-α-600), and observed for 24 h until death. Animals ventilated highly-purified synthetic air...
Inflammation may alter volatile organic compounds (VOCs) in exhaled breath. We therefore used ion mobility spectrometry (IMS) to evaluate breath components two non-infectious inflammatory models. Fifty male Sprague Dawley rats were anesthetized and ventilated for 24 h. Five treatments randomly assigned: (1) lipopolysaccharide low dose [5 mg/kg]; (2) high [10 (3) alpha toxin [40 µg/kg]; (4) [80 and, (5) NaCl 0.9% as control group. Gas was sampled from the expiratory line of ventilator every...
Low-dose isoflurane stimulates spontaneous breathing. We, therefore, tested the hypothesis that compared to propofol sedation for at least 48 h is associated with increased respiratory drive in intensive care patients after stop. All our unit receiving of or 2019 were included. The primary outcome was over 72 stop, defined as an arterial carbon dioxide pressure below 35 mmHg and a base excess more than -2 mmol/L. Secondary outcomes acid-base balance ventilatory parameters. We analyzed 64...
Wir berichten über einen 22jährigen Unfallverletzten, bei dem der linke Harnleiter ohne weitere Verletzung zwischen zwei verhakten Fragmenten des frakturierten Beckens eingeklemmt war. Nach primärer Schienung wurde durch eine operative Mobilisation Fragmente befreit und hierdurch in seiner Funktion normalisiert.