Background: Curcuma longa L., commonly known as turmeric, is renowned for its therapeutic benefits attributed to bioactive compounds, namely curcumin (Cur) and aromatic turmerone (Tur), present in rhizome. These compounds exhibit diverse properties, including anti-inflammatory, antioxidant, anti-tumor effects. However, the topical application of these has a significant potential inducing skin irritation. This study focuses on formulating solid lipid nanoparticle (SLN) carriers encapsulating...

Phytochemicals such as curcumin have great potential in cancer prevention and treatment. However, instability low aqueous solubility of free weaken its anticancer potential. These undesirable problems can be avoided upon loading into nanoparticles containing biocompatible biodegradable polymers poly lactic-co-glycolic acid (PLGA), liposomes or micelles. The interaction drugs release control further enhanced inclusion clay minerals the PLGA nanoparticles. Such offer a new way for drug...

To assess and compare the cytotoxic, genotoxic, apoptotic reactive oxygen species (ROS) generating effects of naringenin (NG) its new derived compound naringenin-oxime (NG-Ox) on MCF-7, HT-29, PC-12 cancer L-929 normal cell lines. The cells were incubated with different doses NG-Ox NG (50–1 000 μmol/L) for 24 h. viability was assessed based ATP assay. Intracellular accumulation ROS determined using fluorescent probes 2′7′-dichlorodihydrofluorescin diacetate. Genotoxic evaluated by alkaline...

ADVERTISEMENT RETURN TO ISSUEPREVLetter to the EditorNEXTA Realistic View on "The Essential Medicinal Chemistry of Curcumin"Fatemeh Bahadori† and Mutlu Demiray*‡§View Author Information† Faculty Pharmacy, Department Pharmaceutical Biotechnology, Bezmialem Vakif University, 34093 Istanbul, Turkey‡ Medical Oncology, Medicana International Istanbul Hospital, 34520 Turkey§ KTO Karatay 42020 Konya, Turkey*E-mail: [email protected]. Tel: +90 332 221 72 00. Fax: 202 00 44.Cite this: ACS Med. Chem....

CCHFV has the potential for human-to-human transmission, and there is no effective approved vaccine or treatment. Therefore, development of an against critical importance. Building on success mRNA-based vaccines during COVID-19 pandemic, this study reports a mRNA candidate expressing NP CCHFV. The in vitro transcript (IVT) was designed with pseudouridine (Ψ) nucleoside modification. As part preclinical characterization IVT candidate, biochemical immunological properties were confirmed Huh-7...

Reversed-phase HPLC analyses of the methanol extract leaves Erica arborea afforded a novel phenylpropanoid glucoside, named ericarborin, together with five flavonoids, dihydromyricetin 3-O-α-L-rhamnopyranoside, quercetin 3-O-β-D-glucopyranoside, apigenin 7-O-β-D-glucopyranoside and 7-O-β-D-(6-O-acetyl-glucopyranoside). While structure ericarborin was determined by extensive 1D 2D NMR analyses, structures all known flavonoids were direct comparison their spectroscopic data respective...

Two amphiphilic block copolymers using hydrophobic poly(ε-caprolactone) (PCL) and hydrophilic poly(ethylene glycol) (PEG) were successfully synthesized. One of them is an (A-b-B)4 type star polymer [(PCL-b-PEG)4] the other one a Y-shaped PEG–(PCL)2. A star-shaped (PCL-b-PEG)4 was prepared by ring-opening polymerization (ROP) ε-caprolactone continued click reaction (PCL-azide)4 PEG-alkyne. The synthesis PEG–(PCL)2 copolymer carried out via Diels-Alder furan protected maleimide...

In continuation of our studies on the genus Salvia fourteen alcoholic extracts species were evaluated for their anticholinesterase activity. Among them, most active extract at 200 μg/mL was found to be S. staminea with inhibition 55.17 and 79.75% against enzymes AChE BChE, respectively. Pure isolated compounds from investigated activity μM, abietane diterpenoids ferruginol taxodione promising isolates, which then further five different concentrations, both exhibited high activity,...

Utilizing carbon dioxide in chemical processes is one of the suggested remedies for reducing its atmospheric concentration. In this paper, simulation propylene carbonate production process using 1,2-propanediol and has been performed. The impact temperature was examined between 75 400°C. It found that as rises, reaction conversion increases. Additionally, recycling ratio range 0.1-0.5, which demonstrates a rise recycle results fall conversion. Furthermore; it observed pressure initially...

We investigated antigenotoxic and antioxidative effects of newly derivatized compound naringenin-oxime (NG-Ox) compared to its mother naringenin (NG) against oxidative damage induced by hydrogen peroxide (HP) in human peripheral blood mononuclear cells (PBMC). Antigenotoxic activity was assessed using alkaline single cell gel electrophoresis assay (comet assay). Oxidative status evaluated measurement total antioxidant status, oxidant lipid hydroperoxide levels the cells. stress index also...

Self-assembly systems (SAS) mainly consist of micelles, and liposomes are the classes Nano Drug Delivery Systems with superior properties compared to traditional therapeutics in targeting cancer tumors. All commercially available nano-formulations chemotherapeutics currently SAS. According our knowledge, a specific toxicity comparison based on material differences has not yet been performed. The purpose this study was evaluate compare two SAS consisting Sterically Stabilized Micelles (SSM)...

Alzheimer's Disease (AD) is one of the most prevalent causes dementia in world, and no drugs available that can provide a complete cure. Cholinergic neurons cerebral cortex AD patients are lost due to increased activity cholinesterase enzymes.Acetylcholinesterase (AChE) Butyrylcholinesterase (BuChE) two major classes cholinesterases mammalian brain. The involvement oxidative stress progression known. Thus, objective this study determine strong ChE inhibitors with anti-oxidant activity.In...

G protein-coupled receptor (GPCR) 87, is overexpressed in various cancer cells especially pancreatic and plays a critical role tumor cell survival. Nano-particles (NP) have become the essential vehicles for nucleotide internalization to cell, due negative charge of nucleotides their poor stability blood circulation. In this study, HEK293T linewas transfected with GPR87-plasmid after which double-stranded RNA molecules targeting GPR87 gene were prepared purified. 1.1B4 lines used as model...

Protection of drug molecules from digestive enzymes and providing their controlled release at the site intestinal inflammation are most important aims oral nano delivery systems (NDDSs).Encapsulation 5-aminosalicylic acid (5-ASA), which is a well-known anti-inflammatory drug, for effective treatment Crohn's disease, ulcerative colitis inflammatory bowel disease (IBD) were aimed in this study.For preparation core-shell structured NDDSs, 5-ASA loaded sodium alginate (Na-Alg) cores with...