Recent work in several model organisms has revealed that apoptotic cells are able to stimulate neighboring surviving undergo additional proliferation, a phenomenon termed apoptosis-induced proliferation. This process depends critically on caspases such as Dronc, the Caspase-9 ortholog Drosophila, and may have important implications for tumorigenesis. While it is known Dronc can induce activity of Jun N-terminal kinase (JNK) mechanistic details this activation largely unknown. It also...

Coronavirus disease 2019 (COVID-19) is an infectious caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has resulted in a vast number of infections and deaths that deeply affect the world. When virus encounters host cell, it binds to angiotensin-converting enzyme 2, then S protein broken down transmembrane protease serine with help furin, allowing enter cell. The elevated inflammatory cytokines suggest cytokine storm, also known as release syndrome, may play major role...

Many studies have shown that honey with high phenolic contents prevents cancer formation. Furthermore, recent demonstrated can be used for the treatment of as well prevention. Antineoplastic effects are often associated their antioxidant contents. However, very few dealt association honeys in terms antiproliferative effects. The aim this study was, therefore, to elucidate cytotoxic, genotoxic, apoptotic, and reactive oxygen species (ROS) generating samples on basis flavonoid Fourteen...

The cancer stem cell hypothesis emphasizes that cancers are driven by cells having properties, and it is believed (CSCs) may be responsible for resistance against therapeutic approaches recurrent tumors. Since the biology of normal breast requires large numbers cells, has been thought play an important role in initiating cancer. A better characterization CSCs appears to essential step improve understanding its management. scope this study was isolate from a line (MCF-7) using surface...

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) poses ongoing global health challenges due to its propensity for mutations, which can undermine vaccine efficacy. With no definitive treatment available, urgent research into affordable and biocompatible therapeutic agents is extremely urgent. Angiotensin converting enzyme-2 (ACE-2), transmembrane protease serine subtype (TMPRSS2), Furin enzymes, allow the virus enter cells, are particularly important as potential drug targets...

The myotonic dystrophies are prototypic toxic RNA gain-of-function diseases. Myotonic dystrophy type 1 (DM1) and 2 (DM2) caused by different unstable, noncoding microsatellite repeat expansions -- (CTG)DM1 in DMPK (CCTG)DM2 CNBP. Although transcription of mutant repeats into (CUG)DM1 or (CCUG)DM2 appears to be necessary sufficient cause disease, their pathomechanisms remain incompletely understood. To study the mechanisms toxicity develop a convenient model for drug screening, we generated...

In this study, we investigated the combined treatment of 5-fluorouracil (5-FU) and Anatolian propolis extract (PE) on colorectal cancer (CRC)using in vitro vivo studies. We exposed luciferase-transfected (Lovo-Luc CRC) cells healthy colon (CCD-18Co) to varying concentrations 5-FU PE assess their genotoxic, apoptotic, cytotoxic effects, as well intracellular reactive oxygen species (iROS) levels. also developed a xenograft model nude mice evaluated anti-tumor effects using various methods....

Spontaneous cartilage regeneration is poor after a defect occurs by trauma, surgical, and other reasons. Importance of producing chondrocytes from stem cells using tissues to repair getting popular. The aim this study was compare the effects injectable produced differentiated adipose tissue-derived mesenchymal chondrocyte isolated directly tissue.Mesenchymal were rat tissue characterized cell-surface markers. Then, they cells. function compared with in terms collagen glycosaminoglycan...

The aim of this in vitro study was to investigate cytotoxic effects dual-cure bulk-fill resin materials polymerized with a third-generation LED light-curing unit (LCU) on L929 fibroblast cells terms morphology and viability. Three novel dual-cure, flowable (Fill-Up!™), bioactive material (ACTIVA™ BioACTIVE-RESTORATIVE™), composite (HyperFIL® HAp) by LCU (VALO™ Cordless) were tested. Each placed plastic rings (4 mm × 5 mm) single layer. Unpolymerized filled each direct contact then...

This study aims to investigate the effects of co-administration nano-Curcumin on anticancer effect nano-Pirarubicin considering fact that clinical use Pirarubicin and other anthracyclines has been limited by development multidrug resistance (MDR) based previous data which have shown Curcumin can down-regulate MDR proteins suppress activity Nuclear factor-kappa B (NF-κB) a protein involved in chemoresistance.Nano micellar formulations both were separately synthesized using...

Objective: Studies have focused on use of non-expired composites. Unfortunately some clinicians still expired composite resins without considering their effects. The objective this in vitro preliminary research was to investigate cytotoxicity expired(6-months) and resins. Materials methods: Expired (E) (NE) samples one bulk-fill (Tetric N-Ceram Bulk-fill [TNB], Ivoclar Vivadent), two nano-hybrid [TN], Vivadent; Clearfil Majesty ES-2 [CM], Kuraray) were tested L929 fibroblast cells. Medium...

Polyphenolic compounds of plant origin are growing interest in cancer prevention and treatment especially because their antioxidant potential contributing anticarcinogenic antimutagenic effects. The diversity Turkeys' flora is remarkable for the development new nutraceuticals or pharmaceuticals. In present study, five local underutilized species: Kaldırık (Trachystemon orientalis), Sirken (Chenopodium album), Yağlı Mancar (Rumex spp.1), Efelek spp.2), Ebegümeci (Malva spp.) that located Bolu...

Objective Intranasal analgesic sprays represent a safe, efficacious method for pain relief, with shorter working time compared to oral painkillers. This study aimed develop nasal using commonly available over-the-counter analgesics, providing an alternative treatment option that is more convenient and potentially effective in managing pain, particularly pediatric patients. Methods Three different spray formulations the contents of diclofenac sodium, ibuprofen, paracetamol were created,...

Background: Cancer is a life-threatening condition with an economic burden on societies. Phytotherapy rapidly taking place in cancer research to increase the success of treatment and quality life. Thymoquinone (TQ) main active phenolic compound obtained from essential oil Nigella sativa (black cumin) plant seed. For long time, black cumin has been used traditionally for remedy different diseases because its various biological effects. It shown that most these effects seeds are due TQ. TQ...

Aim: Glioblastoma, known for its aggressiveness, accounts most malignant gliomas and the efficiency of treatment is still not enough showing remarkably poor prognosis even though a complex approach. Hedera helix an evergreen plant mostly effects on respiratory function, especially in chronic bronchial asthma, as well antimicrobial, anti-inflammatory, antioxidant, potential antitumor properties, while effect glioblastoma cancer underlying mechanism has been elucidated yet. The aim this study...

Aim: To evaluate the effects of theranekron in respect autophagy on gastric cancer that is fifth leading type worldwide.Metods: In present study, metastatic AGS and non-metastatic MKN-45 human cell lines were used together with HEK-293 non-cancer cells as controls.Cytotoxic effect besides appropriate treatment time was investigated through proliferation by using Cell Proliferation assay Kit (MTT) different concentrations drug.The autophagic drug determined LC3-GFP translocation western blot...

Amaç: Işkın bitkisi (Rheum ribes L.) Çin, Hindistan, İran ve Türkiye’de yabani olarak yetişmekte olup birçok tıbbi amaç için kullanılmaktadır. Bu çalışmanın amacı ışkın bitkisinin kök, gövde kabuklarının etanol ekstraktlarının malign melanoma hücrelerine karşı anti-kanser etkinliğini araştırmaktır. Gereç Yöntem: Bitkinin oda sıcaklığında kurutulan kabuk kısımları mikser ile toz haline getirilip %50 24 saat inkübe edildi. Organik faz rotary evaporatörde uçurulup, su fazı liyofilizatörde...

Abstract Objective: We aimed to identify the role of major respiratory viruses in aetiology human nasal polyps using polymerase chain reaction technique. Methods: Thirty patients with and a group 20 healthy (control group) were included this study. Mucosa was obtained from polyposis middle turbinate control by means biopsy. The samples stored at −80 °C until molecular analysis carried out. Results: In group, coronavirus rhinovirus diagnosed one syncytial virus another. polyposis, influenza B...