A5051506193- Acute Myeloid Leukemia Research
- Piperaceae Chemical and Biological Studies
- Cancer, Lipids, and Metabolism
- Histiocytic Disorders and Treatments
- Genetic and rare skin diseases.
- Phagocytosis and Immune Regulation
- Retinoids in leukemia and cellular processes
- Cell Adhesion Molecules Research
- Histone Deacetylase Inhibitors Research
- Pharmaceutical and Antibiotic Environmental Impacts
- Natural product bioactivities and synthesis
- Biological Activity of Diterpenoids and Biflavonoids
- Metabolomics and Mass Spectrometry Studies
- Colorectal Cancer Treatments and Studies
- Protein Hydrolysis and Bioactive Peptides
- Chronic Myeloid Leukemia Treatments
- Ubiquitin and proteasome pathways
- Phytochemistry and Bioactive Compounds
- Molecular Biology Techniques and Applications
- Genomics, phytochemicals, and oxidative stress
- Transgenic Plants and Applications
- Garlic and Onion Studies
- Vascular Malformations and Hemangiomas
- SARS-CoV-2 and COVID-19 Research
- Chemotherapy-induced organ toxicity mitigation
Pontificia Universidad Javeriana
2022-2025
Instituto Nacional de Cancerología
2018-2019
Abstract Although the antitumor effect of P. nigrum has been widely studied, research related to its possible immunomodulatory effects is relatively scarce. Here, and activity an ethanolic extract were evaluated in murine models 4T1 breast cancer B16-F10 melanoma. In vitro evaluations showed that cytotoxic activity, induces apoptotic cell death, a pro-oxidant both lines, but it regulates glucose uptake differently decreasing not B16-F10. significantly reduced tumor size decreased occurrence...
The analysis of tumor metabolism offers promising opportunities for developing new therapeutic strategies. Plant-derived polymolecular drugs can regulate cellular metabolism, making them potential candidates treatment. This study examined the metabolic effects plant-derived drugs—P2Et, Anamu-SC, and Esperanza—on leukemic cell lines (lymphoid myeloid types) primary blasts. included oxidative status, glucose consumption, extracellular acidification, oxygen mitochondrial dynamics, untargeted...
The main limits of current antitumor therapies are chemoresistance, relapses, and toxicity that impair patient quality life. Therefore, the discovery therapeutic alternatives, such as adjuvants to conventional therapy modulate intracellular oxidation state or immune response, remains a challenge. Owing traditional medicine, several uses plants known, indicating promising immunomodulatory effect. We evaluated effect ethanolic extract T. usneoides in vitro vivo models 4T1 breast cancer B16-F10...
Tumor metabolism is a crucial aspect of cancer development, and mitochondria plays significant role in the aggressiveness metastasis tumors. As result, have become promising therapeutic target treatment, leading to development compounds known as mitocans. In our group, we consolidated search anticancer therapies based on natural products derived from plants, obtaining extracts such P2Et Caesalpinia spinosa Anamu-SC Petiveria alliacea, which been shown antitumor activities different models....
Acute leukemias (AL) are aggressive neoplasms with high mortality rates. Metabolomics and oxidative status have emerged as important tools to identify new biomarkers clinical utility. To the metabolic differences between healthy individuals (HI) patients AL, a multiplatform untargeted metabolomic lipidomic approach was conducted using liquid gas chromatography coupled quadrupole-time-of-flight mass spectrometry (LC-QTOF-MS or GC-QTOF-MS). Additionally, total antioxidant capacity (TAC)...
Natural products obtained from Petiveria alliacea (Anamu-SC) and Caesalpinia spinosa (P2Et) have been used for cancer treatment, but the mechanisms by which they exert their antitumor activity appear to be different. In present work, we show that Anamu-SC extract reduces tumor growth in 4T1 murine mammary carcinoma model not B16-F10 melanoma model, unlike standardized P2Et extract. Both extracts decreased levels of interleukin-10 (IL-10) only increased necrosis factor alpha (TNFα) interferon...
Previously, studies have shown that leukemic cells exhibit elevated glycolytic metabolism and oxidative phosphorylation in comparison to hematopoietic stem cells. These metabolic processes play a crucial role the growth survival of Due plasticity tumor cells, use natural products has been proposed as therapeutic alternative due their ability attack several targets including those could modulate metabolism. In this study, potential Petiveria alliacea K562 cell lysates was evaluated by...
<h3>Background</h3> The main limits of current antitumor therapies are chemoresistance, relapses and toxic effects that impair a patient's quality life. Therefore, the discovery therapeutic alternatives, such as adjuvants to conventional therapy modulate intracellular oxidation state, or immune response activation remains challenge.<sup>1 2</sup> Although <i>P. nigrum</i> well-documented, studies on its potential immunomodulatory limited.<sup>3 4</sup> This study assessed activities an...
<h3>Background</h3> Targeting energy metabolism, mitochondrial, and redox homeostasis in acute leukemia can directly affect tumor progression indirectly influence immune cells the microenvironment. Natural products from plants have been extensively studied shown to regulate metabolism both indirectly. Isolated natural or standardized complex extracts Petiveria alliacea, Tillandsia usneoides, Piper nigrum, Caesalpinia spinosa exhibit cytotoxic cytostatic activities on various cell lines...
The Covid-19 infection outbreak led to a global epidemic, and although several vaccines have been developed, the appearance of mutations has allowed virus evade immune response. Added this is existing risk new emerging viruses. Therefore, it necessary explore novel antiviral therapies. Here, we investigate potential