A5079261875- Cervical Cancer and HPV Research
- Folate and B Vitamins Research
- Hepatitis B Virus Studies
- Pharmaceutical Economics and Policy
- Reproductive tract infections research
- Hormonal Regulation and Hypertension
- Public Health in Brazil
- Menopause: Health Impacts and Treatments
- Lipoproteins and Cardiovascular Health
- Antioxidant Activity and Oxidative Stress
- Hormonal and reproductive studies
- Adolescent Sexual and Reproductive Health
- Gout, Hyperuricemia, Uric Acid
- Computational Drug Discovery Methods
- Adipokines, Inflammation, and Metabolic Diseases
- Nutrition, Genetics, and Disease
- T-cell and Retrovirus Studies
- Analytical Methods in Pharmaceuticals
- Genital Health and Disease
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Liver Disease Diagnosis and Treatment
- Renin-Angiotensin System Studies
- Blood Pressure and Hypertension Studies
- Dietary Effects on Health
- Poxvirus research and outbreaks
Universidade Federal de Ouro Preto
2015-2025
Coordenação de Aperfeicoamento de Pessoal de Nível Superior
2022
Universidade Federal de Minas Gerais
2013-2015
Instituto Butantan
2008
A epidemia de HIV se configura como um grave problema saúde pública desde 1981, resultando em doenças oportunistas e altos índices morbimortalidade. O tratamento das complicações não é mais suficiente, uma vez que gera elevados custos para o sistema saúde. Este estudo teve objetivo avaliar a relação entre gastos morbimortalidade por HIV/AIDS no Brasil, investigando seu impacto socioeconômico nas macrorregiões do país. Foi conduzido ecológico série temporal, analisando dados 2012 2021 obtidos...
Globally, cervical cancer is an increasing public health issue, and vaccination against HPV has proven to be effective strategy reduce this neoplasia. The purpose of study was assess the effectiveness quadrivalent vaccine in reducing prevalence incidence infection women, aged 18 24 years old, cities Ouro Preto Mariana, Minas Gerais, Brazil. A concurrent cohort performed, with initial follow-up 12 months. selected young women were interviewed divided into two groups: vaccinated unvaccinated....
Persistent high-risk (HR) human papillomavirus (HPV) infection is necessary for development of precursor lesions and cervical cancer. We investigate persistence clearance HPV infections cofactors in unvaccinated women. Cervical samples 569 women (18–75 years), received routine evaluation the Health Department Ouro Preto, Brazil, were collected subjected to PCR (MY09/11 or GP5+/6+ primers), followed by RFLP sequencing. All interviewed collect sociodemographic behavioral information. Viral was...
The antitumor activity of resveratrol, a polyphenolic compound found mainly in grapes, has been studied several types cancer. In bladder cancer, its antiproliferative effects have already demonstrated; however, mechanism action is not completely understood. aim this study was to evaluate resveratrol (12.5, 25, 50, 100, 150, 200, and 250 μM) possible mechanisms tumor cells with different TP53 gene status (RT4, grade 1, wild type; 5637‐grade 2 T24‐grade 3, mutated). Cell proliferation,...
Abstract Background Infections with Human Papillomavirus (HPV) are the main cause of cervical cancer. Since 2014, HPV vaccine was introduced in Brazilian National Vaccination Calendar. The purpose this study to assess knowledge adolescent girls and their mothers/guardians about vaccine, identify factors associated knowledge, evaluate immunization dropout rate. Methods This a cross-sectional involving mothers/guardians. Participants underwent an interview that addressed sociodemographic data,...
The influence of apolipoprotein E alleles and genotypes on plasma lipid levels was determined in 185 individuals mixed ethnicity living Ouro Preto, Brazil. DNA obtained from blood samples the were by an RFLP-PCR procedure. *3 allele most frequent (72%), followed *4 (20%) *2 (8%); frequency higher lower dyslipidemic group than normal control group. carriers presented LDL total cholesterol compared to carriers. All six expected observed genotyped: E2/2 (2.1%), E4/4 (2.7%), E2/4 (3.7%), E2/3...
Human papillomavirus (HPV) has been extensively studied concerning genomic structure, infection mechanisms, and diversity of types, as well disease progression stages development vaccines.HPV type prevalence can differ in specific populations different countries, according to ethnicity.This is the first report an integrated project evaluate incidence HPV types regions Brazil order obtain data for vaccine development.Cervical samples were collected from women seen at a public hospital...
Climacteric women often experience unfavorable metabolic changes. Consequently, identifying markers that may contribute to such undesirable changes is imperative. This study aimed evaluate serum uric acid (UA) concentration and its association with clinical parameters in climacteric women. We selected 672 between 40 65 years performed interviews, biochemical analyses, blood pressure, anthropometric measurements. UA levels were determined using the enzymatic-colorimetric method. compared...
Cervical cancer has high prevalence and mortality rates in worldwide female population. Persistent infection by high-risk Human Papillomavirus (hr-HPV) is the main cause of this cancer. However, many environmental, genetical, epigenetical cofactors can modulate viral cervical carcinogenesis. Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism a genetic factor that been associated with pathologies, including Nevertheless, studies presented controversial results, varied according to...
We examined the prevalence of human papillomavirus (HPV) infection in a sample Brazilian women presenting normal cervical cytology.Possible interactions between patient characteristics and HPV were analyzed order to provide background data improve cancer screening prophylaxis.Cervical samples 399 women, received for routine evaluation Health Department Ouro Preto, MG, Brazil, subjected HPV-DNA testing by PCR with MY09/11 primers.HPV-positive specimens typed RFLP.A structured epidemiological...
Este trabalho foi composto por um estudo transversal, feito em Ouro Preto, Minas Gerais, Brasil, para avaliar os fatores associados à qualidade de vida mulheres no climatério. Foram usados o questionário SF‐36 e uma entrevista sobre dados socioeconômicos, demográficos, uso medicamentos hábitos vida. A média idade das 113 participantes 53,3 ± 4,4 anos. Dessas, 49,6% conviviam com companheiro 77,4% eram usuárias exclusivas do Sistema Único Saúde. Foi observado que a renda 54% delas era menor...
Papillomaviruses have been reported to be very difficult grow in cell culture.Also, there are no descriptions of cultures from lesions bovine cutaneous papillomatosis, with identification different papilloma virus (BPV) DNA se-different sequences.In the present report, we describe primary
Abstract Background Cervical cancer is caused by high-risk Human Papillomavirus (hr-HPV) infection associated with cofactors that has been analyzed as predictors of the remission or persistence cytological abnormalities persistence. These can be either environmental, epigenetic, genetic. Polymorphism in genes enzymes act on one-carbon metabolism alter their activity and also may cervical carcinogenesis because they affect DNA synthesis repair, gene expression. Therefore, this study aimed to...
Resumo Fundamento Genes e suas variantes associadas a fatores ambientais contribuem para o desenvolvimento do fenótipo hipertenso. O gene da subunidade beta 3 proteína G ( GNB3 ) está envolvido no processo de sinalização intracelular têm sido relacionadas à suscetibilidade hipertensão arterial. Objetivo Determinar associação variante (rs5443:C>T) com arterial, parâmetros bioquímicos, idade obesidade em indivíduos hipertensos normotensos Ouro Preto, Minas Gerais. Método A identificação das foi [...]
Simvastatin is commercially available as tablets and compounded capsules in Brazil. Very few reports regarding these capsules' quality, consequently their efficacy, are available. The pharmaceutical quality of 30 batches 20 mg simvastatin from the market was evaluated by weight determination, content uniformity, disintegration (Brazilian Pharmacopeia), assay dissolution test (USP32 tablet monograph). A HPLC method developed for assay, uniformity test, specifications were also established....
Abstract Objective: The number of specific scales to measure menopausal symptoms has increased significantly in the last decades. However, lack standardization as well prioritization which scale should be used exploring poses problems most populations. Thus, we aimed at demonstrating correlation among four questionnaires evaluating symptoms: Menopause Rating Scale (MRS), Greene Climacteric (GCS), Kupperman Menopausal Index, and Women's Health Questionnaire (WHQ). Methods: We recruited 336...
Background and Objectives: Bacterial vaginosis (BV) is the most common cause of vaginal discharge in world. The study aimed to estimate prevalence identify risk factors associated with bacterial vaginosis. Methods: A cross-sectional was conducted Ouro Preto, Brazil, between February December 2017. Three hundred forty-one women aged 18 years or older, users Brazilian Unified Health System, participated this study. Women who used oral topical antibiotics four weeks prior sample collection had...