A5080442417- Cervical Cancer and HPV Research
- Hepatitis B Virus Studies
- T-cell and Retrovirus Studies
- Immune Response and Inflammation
- Genital Health and Disease
- Molecular Biology Techniques and Applications
- Colorectal and Anal Carcinomas
- Cancer-related molecular mechanisms research
- Cancer-related Molecular Pathways
- Infectious Diseases and Mycology
- Cytomegalovirus and herpesvirus research
- NF-κB Signaling Pathways
- Obesity, Physical Activity, Diet
- Glutathione Transferases and Polymorphisms
- Head and Neck Cancer Studies
- Antimicrobial Peptides and Activities
- Endometrial and Cervical Cancer Treatments
- Poxvirus research and outbreaks
- Herpesvirus Infections and Treatments
- Muscle metabolism and nutrition
- Immunotherapy and Immune Responses
- Reproductive tract infections research
- Women's cancer prevention and management
- Diet and metabolism studies
Universidade Federal de Pernambuco
2012-2024
This study showed the prevalence of human papillomavirus (HPV) variants as well nucleotide changes within L1 gene and LCR HPV16, HPV31, HPV58 found in cervical lesions women from North-East Brazil.
Human papillomavirus (HPV) has been extensively studied concerning genomic structure, infection mechanisms, and diversity of types, as well disease progression stages development vaccines.HPV type prevalence can differ in specific populations different countries, according to ethnicity.This is the first report an integrated project evaluate incidence HPV types regions Brazil order obtain data for vaccine development.Cervical samples were collected from women seen at a public hospital...
We performed an association between high-grade squamous intraepithelial lesions (HSIL), low-grade (LSIL) and single or multiple vaccine-target as well non-vaccine target Human papillomavirus (HPV) types. Using bead-based HPV genotyping, 594 gynecological samples were genotyped. An lesion (SIL) presence of HPV16, 18, 31, 58 56 types calculated. The risk was estimated by using odds ratio (OR) 95% confidence intervals (CI). A total 370 (62.3%) women positive. Among these, 157 (42.7%) presented...
The aim of this study was to examine the prevalence and genetic variability capsid L1 gene rare HPV genotypes that were found in cervical lesions women from North-East Brazil. A total number 263 patients included study. detection performed using PCR followed by direct sequencing MY09/11, as well type-specific detect Alpha-9 species. Epitope prediction determine whether or not variants are inserted B-cell T-cell epitopes. types be 9.47%. detected HPV-53, 54, 56, 61, 62, 66, 70, 81. involved...
The MDM2 gene is the major negative regulator of p53, a tumor suppressor protein. Single nucleotide polymorphism in promoter region leads to increased expression resulting higher levels This event increases attenuation p53 pathway. Polymorphisms this can interfere regulation cellular proliferation. We evaluated whether SNP309 (rs2278744) associated or not with use oral contraceptive heighten susceptibility development cervical lesions women HPV infected.MDM2 was genotyped total 287 patients...
Human papillomavirus (HPV) is responsible for high-grade cervical lesions and cancer. The inflammation plays a key role in cancer progression. In this context, studies propose an association between TNFα IL10 SNPs susceptibility to HPV infection. present work aimed investigate the possible promoter polymorphisms infection carcinogenesis risk women from Brazil. A total of 654 samples was evaluated study. detection performed by PCR genotyping sequencing positive MY09/11 product. Genotyping...
The human beta defensin 1 (hBD-1) antimicrobial peptide is a member of the innate immune system known to act in first line defence against microorganisms, including viruses such as papillomavirus (HPV). In this study, five functional polymorphisms (namely g-52G>A, g-44C>G and g-20G>A 5'UTR c.*5G>A c.*87A>G 3'UTR) DEFB1 gene encoding for hBD-1 were analysed investigate possible involvement these genetic variants susceptibility HPV infection development HPV-associated lesions population...
This study evaluated the presence of Human Papillomavirus (HPV) DNA in cervix and peripheral blood women with cervical intraepithelial neoplasia (CIN I, II, III) healthy individuals. Overall, 139 paired samples CIN III (n = 68) were tested for HPV by using standard procedures. Polymerase chain reaction (PCR) sequencing determined types. Quantification HPV16 E6 E2 genes was performed to determine viral load physical state. detected (21.1% individuals; 48.8-55.5% patients), (46.4% 44.1-77.7%...
The persistence of the human papillomavirus type 16 (HPV16) infection on cervical epithelium contributes to progression cancer. Studies have demonstrated that HPV16 genetic variants may be associated with different risks developing However, E5 oncoprotein HPV16, which is related several cellular mechanisms in initial phases and thus carcinogenesis, still little studied. Here we investigate oncogene assess effects mutations biological function protein. We detected analyzed polymorphisms their...
Human papillomavirus (HPV) infection is considered a risk factor for cervical cancer.Even if the high-risk HPV (HR-HPV) necessary, environmental co-factors and genetic susceptibility also play an important role in cancer development.In this study, possible B.S. Chagas et al.Genetics Molecular Research 16 (3): gmr16039742 association of rs1695 GSTP1 polymorphisms, HR-HPV infection, oral contraceptive use with lesion development women was investigated.The study population comprised 441...
Abstract Cervical carcinoma is the fourth leading cause of death among women worldwide. Epidemiological studies claim that human papillomavirus (HPV) infection a necessary condition for cervical cancer development. Knowledge geographic distribution HPV important in guiding introduction prophylactic vaccines. This study analyzed prevalence samples obtained from with abnormal histopathological diagnosis Northeast Brazil. The included an analysis 211 whose was confirmed intraepithelial...
Cervical cancer is associated with persistent infections by high-risk HPV types that may have nucleotide polymorphisms and, consequently, different oncogenic potentials. Therefore, the objective of this study was to evaluate genetic variability and structural effects E7 oncogene HPV58 in cervical scraping samples from Brazilian women. The carried out patients hospitals metropolitan area Recife, PE, Brazil. most frequent type HPV16, 18 58, respectively. Phylogenetic analysis showed isolates...
Cervical cancer is associated with persistent infections by high-risk Human Papillomavirus (HPV) types that may have nucleotide polymorphisms and, consequently, different oncogenic potentials. Therefore, this study aimed to evaluate the genetic variability and structural effects of E7 oncogene HPV58 in cervical scraping samples from Brazilian women. The was developed patients hospitals metropolitan area Recife, PE, Brazil. most frequent HPV were, descending order abundance, HPV16, 31, 58....
RESUMO -O Papilomavírus humano (HPV) é responsável por lesões cervicais de alto grau e câncer cervical. A inflamação desempenha um papel fundamental na progressão do O presente trabalho teve como objetivo investigar a possível associação entre o polimorfismo promotor TNFα infecção HPV no risco carcinogênese Um total 654 amostras foi avaliada neste estudo. detecção genotipagem foram realizadas PCR. -308 (rs1800629) realizada com sonda fluorogênica alelo-específica.Nossos dados mostram uma...
Objetivo: Propor um protocolo de estudo para perda peso saudável baseado em dieta com restrição carboidratos e exercício intermitente alta intensidade.
 Método: O foi gerado clínico randomizado controlado, visando a baseada na adoção ou sem carboidratos, contínuo (caminhada corrida) intensidade (circuito exercícios funcionais). Participarão do estudo, adultos sobrepesados sedentários, integrantes da comunidade universitária. Os participantes serão avaliados antes após as 12 semanas...