A5065731046- Cervical Cancer and HPV Research
- Women's cancer prevention and management
- Protease and Inhibitor Mechanisms
- Hepatitis B Virus Studies
- Cancer-related molecular mechanisms research
- Essential Oils and Antimicrobial Activity
- Molecular Biology Techniques and Applications
- T-cell and Retrovirus Studies
- Phytochemistry Medicinal Plant Applications
- Reproductive tract infections research
- Ginger and Zingiberaceae research
- Phytochemistry and Bioactive Compounds
- Genital Health and Disease
- Phytochemicals and Antioxidant Activities
- MicroRNA in disease regulation
- Head and Neck Cancer Studies
- Wound Healing and Treatments
- Infectious Diseases and Mycology
- Immune Response and Inflammation
- Moringa oleifera research and applications
- Helicobacter pylori-related gastroenterology studies
- Natural product bioactivities and synthesis
- Plant Toxicity and Pharmacological Properties
- Colorectal and Anal Carcinomas
- Lymphoma Diagnosis and Treatment
Universidade Federal de Pernambuco
2016-2025
Centro de Tecnologias Estratégicas do Nordeste
2024
Universidade Federal de Alagoas
2012
Instituto Adolfo Lutz
2004
Recently, our research group identified and reported 1,8-cineole (CIN), a monoterpene that naturally occur in many aromatic plants, as one of the major constituent essential oil from leaves Hyptis martiusii (EOHM), well characterized gastroprotective action this oil. The aim study was to investigate mechanisms involved antiulcer healing activity CIN, order confirm its correlation with effect EOHM. Wistar rats were exposed different protocols (acute ulceration, gastrointestinal motility...
The rapid advancement of the pandemic caused by SARS-CoV-2 and its variants reinforced importance developing easy-to-edit vaccines with fast production, such as multi-epitope DNA vaccines. present study aimed to construct a synthetic antigen produce vaccine. A database previously predicted Spike Nucleocapsid protein epitopes was created, these were analyzed for immunogenicity, conservation, population coverage, molecular docking. 15 considered immunogenic, conserved even in face that able...
Spondias mombin L. is used in folk medicine for the treatment of inflammation and gastrointestinal diseases. Our study investigated antiulcer activity S. ethanolic extract (SmEE) its majority compounds gallic acid (GA) ellagic (EA). Phytochemical characterization was performed by HPLC. The SmEE screened vitro antioxidant activities using phosphomolybdenum, ABTS, DPPH, FRAP assays. SmEE, GA, EA, or GA + EA evaluated gastric lesion models induced absolute ethanol indomethacin. Following this,...
The aim of this study was to report circulating cell-free DNA using ALU247 and ALU247/ALU115 biomarkers in serum operated non-operated patients with colorectal cancer (CRC).To undertake this, 90 blood samples were collected, including 30 from healthy volunteers; 27 CRC 33 CRC-operated patients. Circulating verified through quantitative real-time PCR (qPCR) ALU115 primers.With regard the ALU115-qPCR biomarker, increased levels significant when compared control (p<0.05). Moreover, ALU247-qPCR...
Ethnomedicinal studies in the Amazon community and Northeast region of Brazil highlight use Libidibia ferrea fruits for treatment gastric problems. However, there are no data literature this pharmacological activity. Thus, aim paper is to provide a scientific basis dry extract L. pods (DELfp) peptic ulcers. Phytochemical characterization was performed by HPLC/MS. In vitro antioxidant activity assessed using DPPH, ABTS, phosphomolybdenum, superoxide radical scavenging The gastroprotective...
Galactomannan films from Cassia grandis seeds, associated or not with Cramoll 1,4, were used on topical wounds of rats for the evaluation healing process during 14days. All evaluated by cytotoxic assay, FTIR and lectin hemagglutinating activity (HA). Forty-five male submitted to aseptic dermal (Ø=0.8cm) divided in groups (n=15): control, test 1, 2, treated respectively saline, galactomannan film immobilized 1,4. Macroscopic evaluations performed clinical observations area measurements,...
Spondias mombin L. (yellow mombin) is a tree with nutritional fruit that commonly consumed in the North and Northeast of Brazil, as juice its pulp rich antioxidant compounds. This study aimed to investigate gastroprotective ulcer healing activities yellow (YMJ) Wistar rats, elucidate possible involved mechanisms. Phytochemical characterization lyophilized was performed by high-performance liquid chromatography (HPLC). The activity YMJ investigated ethanol (25, 50, 100% YMJ) indomethacin...
Matrix metalloproteinases (MMP) have been identified as biomarkers for several diseases, including cancer. The increase in the expression of these enzymes has related to greater tumor aggressiveness. MMP-26 is expressed constitutively endometrium and some cancer cells epithelial origin. However, there a lack studies on its prostatic carcinoma. In this study, evaluation reactivity by immunohistochemistry (IHC) was carried out 150 paraffinized samples representative benign malignant lesions....
A number of recent studies have catalogued global gene expression patterns in a panel normal, tumoral cervical tissues so that potential biomarkers can be identified. The qPCR has been one the most widely used technologies for detecting these biomarkers. However, few investigated correct strategy normalization data assays tissues. aim this study was to validate reference genes ensure accurate quantification mRNA and miRNA levels carcinogenesis. For purpose, some issues obtaining reliable...
This study showed the prevalence of human papillomavirus (HPV) variants as well nucleotide changes within L1 gene and LCR HPV16, HPV31, HPV58 found in cervical lesions women from North-East Brazil.
Hyptis martiusii Benth. is an aromatic plant found in abundance northeastern Brazil that used ethnomedicine to treat gastric disorders. The aim of this study was elucidate the mechanisms action involved gastroprotection essential oil (EOHM) and evaluate its healing capacity. Wistar rats were exposed different protocols subsequently treated with 1% Tween-80 aqueous solution (negative control), pantoprazole, carbenoxolone, N-acetylcysteine (depending on specificity each model) or EOHM....
The aim of this study was to examine the prevalence and genetic variability capsid L1 gene rare HPV genotypes that were found in cervical lesions women from North-East Brazil. A total number 263 patients included study. detection performed using PCR followed by direct sequencing MY09/11, as well type-specific detect Alpha-9 species. Epitope prediction determine whether or not variants are inserted B-cell T-cell epitopes. types be 9.47%. detected HPV-53, 54, 56, 61, 62, 66, 70, 81. involved...
Copaiba oil, extracted from Copaifera multijuga Hayne, Fabaceae, is widely used for medicinal purposes, especially to treat inflammatory processes.However, there no report regarding its effect on reproductive performance after in repeated doses orally.The present study evaluated the effects of oral administration oil (at 200, 500 or 2500 mg/kg) water (control) eight weeks male Wistar rats.Treated males mated untreated females, and parameters as fertility rates, absolute relative mass...
The aim of this study was to describe the prevalence human papillomavirus (HPV), distribution different HPV types, and putative risk factors for infection among HPV-positive women from State Alagoas, Northeast Brazil. We analyzed data 515 patients attending public private health centers. DNA cervical samples extracted genotyping performed by polymerase chain reaction using MY09/11 consensus primers followed direct sequencing. chi-squared test independence used assess statistical differences...
The MDM2 gene is the major negative regulator of p53, a tumor suppressor protein. Single nucleotide polymorphism in promoter region leads to increased expression resulting higher levels This event increases attenuation p53 pathway. Polymorphisms this can interfere regulation cellular proliferation. We evaluated whether SNP309 (rs2278744) associated or not with use oral contraceptive heighten susceptibility development cervical lesions women HPV infected.MDM2 was genotyped total 287 patients...
Simarouba amara stem bark decoction has been traditionally used in Brazil to treat malaria, inflammation, fever, abdominal pain, diarrhea, wounds and as a tonic. In this study, we investigate the hepatoprotective effects of aqueous extract S. (SAAE) on CCl4-induced hepatic damage rats. SAAE was evaluated by high performance liquid chromatography. The animals were divided into six groups (n = 6/group). Groups I (vehicle—corn oil), II (control-CCl4), III, IV, V VI pretreated during 10...
Hyptis martiusii Benth. (Lamiaceae) is found in abundance Northeastern Brazil where it used traditional medicine to treat gastric disorders. Since there are no studies reporting the toxicity and safety profile of this species, we investigated repeated-doses essential oil (EOHM). Swiss mice both sexes were orally treated with EOHM (100 500 mg/kg) for 30 days, biochemical, hematological, morphological parameters determined. No signs or deaths recorded during treatment EOHM. The body weight...