A5051768989- Plant biochemistry and biosynthesis
- Microbial Natural Products and Biosynthesis
- Phytochemistry and biological activities of Ficus species
- Antioxidant Activity and Oxidative Stress
- Alkaloids: synthesis and pharmacology
- Piperaceae Chemical and Biological Studies
- Banana Cultivation and Research
- Phytochemicals and Antioxidant Activities
- Phytochemistry and biological activity of medicinal plants
- Marine Sponges and Natural Products
- Plant Physiology and Cultivation Studies
- Biological and pharmacological studies of plants
- Plant Pathogens and Fungal Diseases
- Phytochemistry and Biological Activities
- Plant Pathogenic Bacteria Studies
- Vitamin C and Antioxidants Research
Victoria University of Wellington
2022-2023
Maurice Wilkins Centre
2022-2023
University of Otago
2015-2021
The significant structural diversity and potent bioactivity of the fungal indole diterpenes (IDTs) has attracted considerable interest in their biosynthesis. Although substantial skeletal is generated by action noncanonical terpene cyclases, comparatively little known about these enzymes, particularly those involved generation subgroup containing emindole SA DA, which show alternate terpenoid skeletons. Here, we describe IDT biosynthetic machinery generating unusual architectures from...
Abstract Nodulisporic acids (NAs) are structurally complex potent antiinsectan indole diterpenes. We previously reported the biosynthetic gene cluster for these metabolites in Hypoxylon pulicicidum and functionally characterised first five steps of pathway. Here we reveal a highly array, furnishing multiple end products through expression components Penicillium paxilli . show that seven additional cluster‐encoded comprise machinery elaborate precursor NAF this branched The combined action...
Cytotoxic amides have been isolated from the fruits of endemic New Zealand medicinal plant kawakawa, <i>Macropiper excelsum</i> (Piperaceae). The main amide was piperchabamide A and this is first report rare compound outside genus <i>Piper</i>. Eleven other were purified including two new compounds with unusual 3,4-dihydro-1(2H)-pyridinyl group. fully characterized by 2D NMR spectroscopy, which showed a slow exchange between rotamers about bond, they chemically synthesized. In view antitumor...
Indole terpenoids make up a large group of secondary metabolites that display an enticing array bioactivities. While indole diterpene (IDT) and rarely sesquiterpene (IST) pathways have been found individually in filamentous fungi, here we show both cluster types are encoded within the genome Tolypocladium album. Through heterologous reconstruction, demonstrate SES encodes for IST biosynthesis can tailor IDT substrates produced by TER cluster.
2-O-β-d-Glucopyranosyl l-ascorbic acid (AA-2βG) is a stable, bioavailable vitamin C (AA) derivative. We report the distribution and seasonal variation of AA-2βG in apples its occurrence other domesticated crops wild harvested Ma̅ori foods. Liquid chromatography–mass spectrometry analyses showed high concentrations crab (Malus sylvestris) but low apples. Leaves apple cultivars contained similar intermediate concentrations. Fruits leaves were analyzed: mainly Rosaceae also Actinidiaceae...
Abstract Nodulisporic acids (NAs) are structurally complex potent antiinsectan indole diterpenes. We previously reported the biosynthetic gene cluster for these metabolites in Hypoxylon pulicicidum and functionally characterised first five steps of pathway. Here we reveal a highly array, furnishing multiple end products through expression components Penicillium paxilli . show that seven additional cluster‐encoded comprise machinery elaborate precursor NAF this branched The combined action...