A5072320459- Antibiotic Resistance in Bacteria
- Adrenal Hormones and Disorders
- Neutropenia and Cancer Infections
- Bacterial Identification and Susceptibility Testing
- Urinary Tract Infections Management
- COVID-19 Clinical Research Studies
- Sexual Differentiation and Disorders
- Nosocomial Infections in ICU
- Diet and metabolism studies
- Pediatric Urology and Nephrology Studies
- Diabetes Management and Research
- Streptococcal Infections and Treatments
- Syphilis Diagnosis and Treatment
- Congenital Diaphragmatic Hernia Studies
- Healthcare cost, quality, practices
- Parathyroid Disorders and Treatments
- Salivary Gland Disorders and Functions
- Delphi Technique in Research
- Gastroesophageal reflux and treatments
- Cardiovascular Function and Risk Factors
- HIV, Drug Use, Sexual Risk
- Growth Hormone and Insulin-like Growth Factors
- Genetic Syndromes and Imprinting
- Clostridium difficile and Clostridium perfringens research
- Central Venous Catheters and Hemodialysis
Children's National
2021-2024
Eunice Kennedy Shriver National Institute of Child Health and Human Development
2023-2024
NewYork–Presbyterian Brooklyn Methodist Hospital
2019-2020
Brown University
2016-2017
Rhode Island Hospital
2016-2017
The impact of the COVID-19 pandemic on incidence pediatric type 1 (T1D) and 2 diabetes (T2D) severity presentation at diagnosis is unclear.A retrospective comparison 737 youth diagnosed with T1D T2D during initial 12 months in preceding years was conducted a tertiary care center.Incident cases rose from 152 to 158 before (3.9% increase) 182 (15.2% increase). prevalence diabetic ketoacidosis (DKA) increased over 3 (41.4%, 51.9%, 57.7%, p = 0.003); severe DKA as compared (16.8% vs. 28%,...
In recent years, a growing amount of research has begun to focus on the oral microbiome due its links with health and systemic disease. The numerous advantages that make it particularly useful for clinical studies, including non-invasive collection, temporal stability, lower complexity relative other niches, such as gut. Despite discoveries made in this area, is unknown how responds short-term hospitalization. Previous studies have demonstrated gut extremely sensitive hospitalization these...
Allgrove syndrome or triple A (3A) is a multisystem disorder which classically involves the triad of esophageal achalasia, alacrima, and adrenal insufficiency due to adrenocorticotropin hormone insensitivity. It follows an autosomal recessive pattern inheritance associated with mutations in AAAS (achalasia-addisonianism-alacrima syndrome) gene. Since its first description 1978, knowledge on clinical genetic characteristics has been expanding; however, current literature limited case reports...
There is emerging speculation that the inflammatory state associated with SARS-CoV-2 infection may trigger autoimmune conditions, but no causal link established. are reports of thyroiditis and adrenal insufficiency in adults post-COVID-19. We describe first pediatric report hypothyroidism after COVID-19.A 14-year-old previously healthy girl, vitiligo, presented shock following 1 week fever, lethargy, diarrhea, vomiting. Three weeks prior, she had congestion fatigue known familial exposure...
Background Advanced age, history of hospitalization, and antibiotic consumption are associated with the pathogenesis Clostridium difficile infection ( CDI ). Long‐term care facilities LTCF s) represent a setting where has been increasingly reported. We aimed to estimate actual attributable burden stay determine characteristics disease epidemiology in this setting. Design IRB ‐approved retrospective cohort study. Setting community. Participants One thousand seven hundred sixty‐one patients....
Gonorrhea is the second most commonly reported identifiable disease in United States (U.S.). Importantly, more than 25% of gonorrheal infections demonstrate antibiotic resistance, leading Centers for Disease Control and Prevention (CDC) to classify gonorrhea as an "urgent threat".We examined association infection rates with incidence HIV socioeconomic factors. A county-level multivariable model was then constructed.Multivariable analysis demonstrated that [Coefficient (Coeff): 1.26, 95%...
Primary hyperparathyroidism secondary to an ectopic parathyroid adenoma is rare among children and adolescents.We describe the case of 11-year-old girl with incidentally diagnosed primary intrathymic performed a review related literature.99mTechnetium sestamibi single-photon emission computerized tomography/computed tomography 4-dimensional computed confirmed location adenoma. The patient underwent thoracoscopic thymectomy remained normocalcemic elevated hormone showing downward trend....
Abstract Context Children with congenital adrenal hyperplasia (CAH) are at risk for early puberty. Gonadotropin-releasing hormone analog (GnRHa) is frequently used and can decrease bone mineral density (BMD). Objective Our aim was to investigate the effect of GnRHa therapy on BMD in a longitudinal study patients CAH spanning both childhood adulthood. Design Setting Sixty-one classic due 21-hydroxylase deficiency (20 treated GnRHa) were followed dual-energy X-ray absorptiometry (DXA) scans...
Abstract Context Measuring health-related quality of life (HRQoL) is a crucial aspect evaluating health care outcomes. Patients with congenital adrenal hyperplasia (CAH) often self-report deficiencies in HRQoL. Objective The aim our study was to develop disease-specific patient-reported outcome (PRO) instrument evaluate the HRQoL patients > 16 years old classic CAH. Methods Following FDA guidelines for developing PRO instruments, we developed conceptual framework instrument. A...
Abstract Disclosure: M.E. Flokas: None. L. Yang: K. Middleton: R.W. Persky: S. Kollender: M. Parker: D.P. Merke: Grant Recipient; Self; Diurnal, received unrelated research funds through the National Institutes of Health Cooperative Research and Development Agreement., D.P.M. from Neurocrine Biosciences Agreement. Objectives: Measuring health-related quality life (HRQoL) is a crucial often required process evaluating health care outcomes. The aim our study to develop disease-specific patient...