A5027843867- Amyloidosis: Diagnosis, Treatment, Outcomes
- Inflammasome and immune disorders
- Renal Diseases and Glomerulopathies
- Gout, Hyperuricemia, Uric Acid
- Chronic Lymphocytic Leukemia Research
- Peripheral Neuropathies and Disorders
- interferon and immune responses
- Multiple Myeloma Research and Treatments
- Parathyroid Disorders and Treatments
- Urticaria and Related Conditions
- Alzheimer's disease research and treatments
- Sarcoidosis and Beryllium Toxicity Research
- Autoimmune and Inflammatory Disorders Research
- Inflammatory Myopathies and Dermatomyositis
- S100 Proteins and Annexins
- Dermatological and Skeletal Disorders
- IL-33, ST2, and ILC Pathways
- Biomarkers in Disease Mechanisms
- Spondyloarthritis Studies and Treatments
- Drug-Induced Hepatotoxicity and Protection
- Chronic Kidney Disease and Diabetes
- Rheumatoid Arthritis Research and Therapies
- Mitochondrial Function and Pathology
- Biomedical Research and Pathophysiology
- IgG4-Related and Inflammatory Diseases
Sechenov University
2015-2024
Pirogov Russian National Research Medical University
2022
Lomonosov Moscow State University
2020
First Pavlov State Medical University of St. Petersburg
2020
Eastbridge Hospital
2020
Peoples' Friendship University of Russia
2019
Belgorod National Research University
2019
The article presents the case report of a rare hereditary form systemic ATTR-amyloidosis in Russian patient with discussion approaches to diagnosis and treatment this form, also based on own experience management such patients. Modern ideas about pathogenesis disease as well detailed information clinical manifestations amyloid cardiopathy other organs are presented. nature structural hemodynamic changes heart is discussed basis experience, including own, ultrasound examination patients...
The term «monoclonal gammopathies of undetermined significance» (MGUS) was introduced by R. Kyle in 1978 to designate the condition characterized presence ofsmall amounts ofM-protein serum. In some patients, such remains benign for a long time but predetermines development multiple myeloma and other B-lymphocytic tumours. Also, it can provoke non-cancerous diseases due toxic action monoclonal proteins (immunoglobulins free light chains) on various organs, especially kidneys. MGUS-associated...
Monoclonal gammopathy of renal significance (MGRS) is a new nosology in modern nephrology and oncohematology. MGRS defined as kidney injury due to nephrotoxic monoclonal immunoglobulin produced by the B-cell line clone which does not reach hematological criteria for specific treatment initiation. protein’s pathological effects on parenchyma result irreversible decline function till end stage disease that with position International Consensus hematologists nephrologists determinates critical...
Особенности эволюции и прогностическое значение поражения сердца у больных системным AL-амилоидозомВ.В.Рамеев, Л.В.Козловская, А
Aim. To investigate an influence of the currently changed etiologic structure AA-amyloidosis on diagnosis and treatment tactics. Materials methods. In 110 patients with АА-amyloidosis followed during full disease duration (1 month 29 years) etiology, clinical manyfestations approaches to diagnose were evaluated. With ELISA levels amyloid precursor acute phase inflammation reactant SAA neutrophil activity marker S100A12 measured. Results. Among most common causes at present stage, in addition...
An article reviews the current concepts of pathogenesis and management gout hyperuricemia.Available evidence suggests that complications hyperuricemia, including arterial hypertension metabolic syndrome, are partly related to persisting low-grade inflammation.Treatment for should include medications reduce serum uric acid level inhibit autoinflammation.The authors report a rare case AA-amyloidosis in patient with chronic gout.
Monoclonal gammopathy of renal significance (MGRS) is a new nosology in modern nephrology and oncohematology. MGRS defined as kidney injury due to nephrotoxic monoclonal immunoglobulin produced by the B-cell line clone which does not reach hematological criteria for specific treatment initiation. protein’s pathological effects on parenchyma result irreversible decline function till end stage disease that with position International Consensus hematologists nephrologists determinates critical...
To determine the possibility of using serum proinflammatory calcium-binding protein, or calgranulin C (S100A12), to assess activity and therapeutic efficiency in patients with periodic disease (PD) other familial fevers (FPFs).Thirty-five PD FPDs, which were verified by molecular genetic study, examined. In accordance activity, divided into 2 groups. The investigators determined concentration S100A12 solid-phase enzyme immunoassay that acute-phase inflammatory markers (erythrocyte...
Aim. To describe prognostic meaning of cardiac and other principal clinical manifestations systemic AL-amyloidosis in their interrelations. Material methods . It has been made long-time survival analysis 147 patients with AL-amyloidosis. In the special investigation group (n=58) AL (n=55) ATTR (n=3) amyloidotic cardiopathy there were evaluated prognostically important structural functional changes myocardium standard impulse-wave tissue dopplerometric echocardiography comparison NTproBNP...
AA amyloidosis complicates various chronic inflammatory disorders and is characterized by the accumulation of amyloid fibrils composed serum A protein, an acute phase reactant. In recent decades, role infections rheumatoid arthritis in ethiology have decreased significantly as a result their treatment improvement, whereas both monogenic (familial Meditarranean fever, cryopirin-associated periodic syndrome, etc.) or polygenic (ankylosing spondilitis, psoriatic arthritis, adult onset Still’s...
The aim – to present the experience of diagnosis, management, and therapy with IL-1 inhibitors in patients Schnitzler’s syndrome (SchS) according a multicenter Russian cohort. Materials methods . In an observational retrospective study for 10-year period (2012–2022), 17 SchS who were admitted hospital or observed on outpatient basis, among them 8 women, 9 men, included study. diagnosis all corresponded Strasbourg diagnostic criteria. Results age ranged from 25 81 years (Me 53 [46; 56]...
The emergence of effective therapy for AL amyloidosis with cardiac involvement raises the challenge a comprehensive assessment risk SCD and its prevention. This problem should be approached individually possibility ICD implantation considered in patients ventricular arrhythmias: frequent extrasystoles unstable tachycardia. With development rhythm conduction disturbances amyloidosis, one keep mind myocarditis, who have suffered new coronavirus infection, possible role induction both...
Paraproteinemic polyneuropathies (PPN) occur generally infrequently and arise from diseases, associated with formation accumulation of a pathological protein, commonly known as paraprotein, which is typically an immunoglobulin or its free light chain. Such diseases include the following: monoclonal gammopathy undetermined significance, multiple myeloma, Waldenström’s macroglobulinemia, AL amyloidosis, POEMS syndrome, etc. Diagnosis PPN challenging due to nonspecific, indistinct atypical...
Lifelong administration of colchicine is the mainstay treatment for familial Mediterranean fever (FMF), whereas canakinumab, a monoclonal antibody that blocks effects interleukin (IL)-1β, can be used in case resistance or its poor tolerability.
This clinical case series presents descriptions of 3 patients with familial Mediterranean fever (FMF) who have atypical manifestations and abnormal inheritance mechanisms in terms Gregor Mendel's laws. Although molecular genetic testing can help disease diagnosis, it is not always conclusive. The primary need for cases to explain the mechanism inflammation select optimal therapy. These observations demonstrate changes spectrum phenotypic FMF context widespread introduction methods.
In the history of amyloidosis studying concept liquids dyscrasia has been predominated and finally it is resulted in accepting a serum protein-precursor as leading amyloidogenic factor disease pathogenesis. Consequently basic diagnostic treatment strategy was aimed to find eliminate this protein from blood approach evidenced high effectiveness most frequent AA AL-amyloidosis characterized with anomaly levels precursors blood. At same time there are less slower progressing inheritant forms...
Monoclonal gammopathy of renal significance (MGRS) is a new nosology in modern nephrology and oncohematology. MGRS defined as kidney injury due to nephrotoxic monoclonal immunoglobulin produced by the B-cell line clone which does not reach hematological criteria for specific treatment initiation. protein’s pathological effects on parenchyma result irreversible decline function till end stage disease that with position International Consensus hematologists nephrologists determinates critical...