A5054035808- Ion Channels and Receptors
- Pain Mechanisms and Treatments
- Dermatology and Skin Diseases
- Molecular Sensors and Ion Detection
- Advanced biosensing and bioanalysis techniques
- Herpesvirus Infections and Treatments
- Luminescence and Fluorescent Materials
- Ion channel regulation and function
- Peripheral Neuropathies and Disorders
- Carbon and Quantum Dots Applications
- Toxin Mechanisms and Immunotoxins
- Stress Responses and Cortisol
- Urticaria and Related Conditions
- Pharmacological Effects of Natural Compounds
- Liver Disease Diagnosis and Treatment
- Per- and polyfluoroalkyl substances research
- Mycotoxins in Agriculture and Food
- MicroRNA in disease regulation
- Sulfur Compounds in Biology
- Blood properties and coagulation
- Respiratory and Cough-Related Research
- Exercise and Physiological Responses
- Olfactory and Sensory Function Studies
- Berberine and alkaloids research
- Advanced Nanomaterials in Catalysis
Duke University
2021-2025
University of Maryland Eastern Shore
2016-2024
China Agricultural University
2020-2023
Duke University Hospital
2022
Duke Medical Center
2022
China Three Gorges University
2015
Significance Osteoarthritis is a global health problem that affects load-bearing joints, causing loss of mobility and enormous healthcare costs. However, disease-modifying approaches are lacking. Here, we report cellular mechanism inflammatory signaling in chondrocytes, the component cartilage. We show how osteoarthritis-relevant levels interleukin-1α reprogram articular chondrocytes so they become more susceptible to mechanical trauma, which sense via Piezo1/2-mechanosensitive ion channels....
Background & AimsLimited understanding of pruritus mechanisms in cholestatic liver diseases hinders development antipruritic treatments. Previous studies implicated lysophosphatidic acid (LPA) as a potential mediator pruritus.MethodsPruritogenicity lysophosphatidylcholine (LPC), LPA's precursor, was examined naïve mice, and nonhuman primates. LPC's pruritogenicity involving keratinocyte TRPV4 studied using genetic pharmacologic approaches, cultured keratinocytes, ion channel physiology,...
Senescent hepatocytes accumulate in metabolic dysfunction-associated steatotic liver disease (MASLD) and are linked to worse clinical outcomes. However, their heterogeneity lack of specific markers have made them difficult target therapeutically. Here, we define a senescent hepatocyte gene signature (SHGS) using vitro vivo models show that it tracks with MASLD progression/regression across mouse large human cohorts. Single-nucleus RNA-sequencing functional studies reveal SHGS+ originate from...
Aflatoxin B1 (AFB1) is a kind of potently carcinogenic fungal metabolite in food threatening human health, and it crucial challenging to develop advanced nonimmune approaches for AFB1 determination. Addressing this challenge, we successfully constructed nanoassembly (PdE-PDI/SDS) by noncovalently coupling cationic perylene diimide derivative (PdE-PDI) sodium dodecyl sulfate (SDS), exhibiting high-density charges specific surface area rapid sensing AFB1. The large electronic conjugate...
AIM:To determine the role of Notch1 and Hes1 in regulating activation hepatic stellate cells (HSCs) whether is regulated by transforming growth factor (TGF)/bone morphogenetic protein (BMP) signaling. METHODS:Immunofluorescence staining was used to detect expression desmin, glial fibrillary acidic myofibroblastic marker α-smooth muscle actin (α-SMA) after freshly isolated, normal rat HSCs had been activated culture for different numbers days (0, 1, 3, 7 10 d).The α-SMA, collagen1α2 (COL1α2),...
Developing a rapid and simple method for the detection of berberine chloride (BBC), one kind natural antibiotic, is significant to ensure reasonable control administration antibiotic residues in food other feed. In this report, sensitive selective fluorescent probe based on water-soluble perylene diimide derivative (PDI-Asp) has been screened (BBC). The sensing performance mechanism were systematically investigated by using UV–vis fluorescence spectroscopic techniques. Meanwhile, influencing...
Herpes simplex virus-type 1 (HSV-1) infection of sensory neurons may lead to a significant reduction in the expression voltage-activated Na+ and Ca2+ channels, which can disrupt transmission pain information. Viral also results secretion various pro-inflammatory cytokines, including interleukin (IL)-6. In this work, we tested whether IL-6 regulates channels post-HSV-1 ND7/23 sensory-like neurons. Our demonstrate that HSV-1 causes decrease protein Cav3.2 T-type channel subunit, despite...
Abstract is missing (Short communication)
In this work, we report a novel fluorimetric sensing system for the visual and rapid detection of bipyridylium herbicides (paraquat diquat) using polyelectrolyte-induced nanoassembly strategy in 100% aqueous media. This approach relies on formation supramolecular assemblies between pyrenyl probe (N,N,N-trimethyl-4-(pyren-1-yl)butan-1-aminium bromide, PyBTA) polyelectrolyte (poly(4-styrenesulfonic acid), PSS), which could promote paraquat complexation by synergy noncovalent forces such as...
There is an unmet need to identify new therapeutic targets for temporomandibular disorder (TMD) pain because current treatments are limited and unsatisfactory. TMEM100, a two-transmembrane protein, was recently identified as regulator weaken the TRPA1-TRPV1 physical association, resulting in disinhibition of TRPA1 activity sensory neurons. Recent studies have also shown that Tmem100, Trpa1, Trpv1 mRNAs were upregulated trigeminal ganglion (TG) after inflammation joint (TMJ) associated...
The molecular mechanisms of pain associated with alphaherpesvirus latency are not clear. We hypothesize that the voltage-gated sodium channels (VGSC) on dorsal root ganglion (DRG) neurons controlling electrical impulses may have abnormal activity during latent viral infection and reactivation. used herpes simplex virus 1 (HSV-1) to infect human DRG-derived neuronal cell line HD10.6 in order study establishment maintenance latency, reactivation, changes functional expression VGSCs....
Herpes Simplex Virus Type -1 (HSV-1) infections can cause serious complications such as keratitis and encephalitis. The goal of this study was to identify any changes in the concentrations volatile organic compounds (VOCs) produced during HSV-1 infection epithelial cells that could potentially be used an indicator a response stress. An additional objective if VOCs released from acute may influence subsequent neuronal facilitate latency. To investigate these hypotheses, Vero were infected...
Low intraneuronal chloride in spinal cord dorsal horn (SCDH) pain relay neurons is of critical relevance for physiological transmission primary sensory afferents because low dictates GABA-ergic and glycin-ergic neurotransmission to be inhibitory. If neuronal rises unphysiological levels, the gate becomes corrupted, with resulting behavioral hallmarks hypersensitivity allodynia, example pathological pain. relies on robust gene expression Kcc2 sustained transporter function KCC2...