A5047754861- Inflammatory Bowel Disease
- Microscopic Colitis
- Cancer-related molecular mechanisms research
- Helicobacter pylori-related gastroenterology studies
- Immunodeficiency and Autoimmune Disorders
- Cannabis and Cannabinoid Research
- MicroRNA in disease regulation
- Respiratory viral infections research
- Gut microbiota and health
- Bacteriophages and microbial interactions
- Asthma and respiratory diseases
- Eosinophilic Esophagitis
- Substance Abuse Treatment and Outcomes
- Aortic aneurysm repair treatments
- Prenatal Substance Exposure Effects
- IL-33, ST2, and ILC Pathways
- Epigenetics and DNA Methylation
- Aortic Disease and Treatment Approaches
- Gastroesophageal reflux and treatments
- Microbial infections and disease research
- Circular RNAs in diseases
- Male Breast Health Studies
- Celiac Disease Research and Management
- BRCA gene mutations in cancer
- Hippo pathway signaling and YAP/TAZ
National and Kapodistrian University of Athens
2015-2024
Creative Research Enterprises (United States)
2016
Alcohol use disorder (AUD) represents a major public health issue which affects millions of people globally and consist chronic relapsing condition associated with substantial morbidity mortality. The gut microbiome plays crucial role in maintaining overall has emerged as significant contributor to the pathophysiology various psychiatric disorders. Recent evidence suggests that is intimately linked development progression AUD, alcohol consumption directly impacting its composition function....
Background: To date, the elucidation of serum protein alterations in male breast cancer (MBC) has not been extensively studied, due to rarity disease. Materials and Methods: In present work, two-dimensional gel electrophoresis (2-DE) matrix-assisted laser desorption ionization-time flight mass spectrometry (MALDI-TOF MS) were employed detect differences expression between patients with MBC healthy controls. Results: A panel differentially expressed proteins was identified, including involved...
BACKGROUND: Long non-coding RNAs (lncRNAs) are emerging as candidate biomarkers of cancer, having regulatory functions in both oncogenic and tumor-suppressive pathways. Concerning pancreatic cancer (PC), deregulation lncRNAs involved tumor initiation, invasion, metastasis seem to play a k ey role. However, data is scarce about mechanism lncRNA expression. OBJECTIVE: The aim our study was investigate the contribution two polymorphisms (rs1561927 rs4759313 PVT1 HOTAIR, respectively) PC...
Abstract Background Anti-TNF agents have been a cornerstone of IBD therapy; however, response to treatment has variable, and clinically applicable biomarkers are urgently needed. We hypothesized that the type I II interferon (IFN) signatures may be confounding factor for antitumor necrosis (TNF) via interactions with host its gut microbiota. Methods Peripheral blood from 30 patients 10 healthy controls was subjected real-time quantitative polymerase chain reaction IFN genes (IFNGs), both at...
Inflammatory bowel disease (IBD) seems to arise from an interplay between genetic and environmental factors.
Canine inflammatory bowel disease (IBD) is a group of chronic gastrointestinal (GI) disorders still largely unknown etiology. IBD diagnosis time-consuming and costly as other diseases with similar signs should be initially excluded. In human microRNA (miR) expression changes have been reported in GI mucosa blood. Thus, there possibility that miRs may provide insight into pathogenesis, even treatment canine IBD. The aim this study was to determine the colonic mucosal serum relative panel dogs...
To investigate the correlation between rs2910164, rs11 614913, rs113054794, and rs188519172 polymorphisms response to anti-TNF treatment in patients with Crohn's disease (CD).One hundred seven CD based on standard clinical, endoscopic, radiological, pathological criteria were included study. They all received infliximab or adalimumab intravenously subcutaneously at induction doses as per international guidelines. Clinical biochemical was assessed using Harvey-Bradshaw index CRP levels...
Infliximab trough levels (IFX-TLs) and antibodies to infliximab (ATIs) have been suggested as useful markers for the optimization of treatment in inflammatory bowel disease (IBD). We aimed estimate patterns over time IFX-TLs ATIs IBD patients on maintenance with IFX.Two different measurements were performed (ELISA; Eagle BioSciences) at a 10-month interval using serum samples consecutive IFX. Certain biomarkers [hemoglobin, erythrocyte sedimentation rate, C-reactive protein (CRP), platelets,...
The development of methods and miniaturized systems for fast reliable quantitative determinations at the Point-of-Care is a top challenge priority in diagnostics. In this work, compact bench-top system, based on White Light Reflectance Spectroscopy, introduced evaluated an application with high clinical interest, namely determination C-Reactive protein (CRP) human blood samples. system encompassed all necessary electronic optical components performance assay, while dedicated software...
Nine genetic loci have been associated with abdominal aortic aneurysm (AAA) susceptibility, including DAB2IP. This gene is playing a role in apoptosis, cell proliferation and epithelial-to-mesenchymal transition cancers. study aimed to elucidate the differential expression levels of DAB2IP AAA tissues investigate whether mir-363-3p EZH2 can be considered as potential mediators its expression.18 samples 15 non-aneurysmatic controls were collected. Relative mRNA DAB2IP, measured using...
Background/Aim: Recent evidence suggests that survivin, a member of the inhibitors apoptosis family prevents cell death and regulates division is implicated in pathogenesis inflammatory bowel disease (IBD). The aim study was to identify possible association between individual genetic variation, IBD susceptibility, response infliximab (IFX). Material Methods: expression levels survivin were detected pathologic areas fresh tissues blood samples by real-time reverse transcriptase - polymerase...
Alcohol use disorder (AUD) is a chronic, multifactorial psychiatric condition with an enormous impact on public health and social cost. Genetic studies suggest heritability, genome-wide association (GWAS) have revealed genetic polymorphisms influencing AUD development. Our study aimed to investigate known variants located in ADH1B, DRD2, FAAH, SLC39A8, GCKR, PDYN genes (rs1229984, rs7121986, rs324420, rs13107325, rs1260326, rs2281285 respectively) Greek cohort order shed more light the...
The central dogma of molecular biology, has remained a cornerstone classical biology. However, serendipitously discovered microRNAs (miRNAs) in nematodes paradigmatically shifted our current knowledge the intricate mechanisms during transitions from transcription to translation. discovery miRNA captured considerable attention and appreciation, we had witnessed an explosion field non-coding RNAs. Ground-breaking discoveries RNAs have helped better characterization long (LncRNAs). There is...
The measurement of infliximab trough levels (IFX-TLs) in patients with inflammatory bowel disease (IBD) is performed to optimize treatment. However, the association between development adverse events (AEs) and IFX-TLs has not been sufficiently studied thus far. To investigate possible AEs Greek IBD receiving maintenance treatment IFX.A retrospective analysis registry data Gastroenterology Department University Hospital Heraklion, from at least one available IFX-TL during years 2016 2017 was...
Background Inflammatory bowel disease (IBD) seems to arise from an interplay between genetic and environmental factors.CLEC5A CLEC7A genes code for 2 members of the C-type lectin receptor superfamily, which participate in immune response against various pathogens, mediating inflammatory signaling.CLEC5A polymorphisms have been linked risk Crohn's (CD), whereas has implicated fungal dysbiosis, chemically induced colitis mice undertreated ulcerative (UC) humans.This study aimed explore how...
Developmentally early cells are mobilized into peripheral blood in Crohn's disease (CD) patients. OCT4, is considered to be important sustaining the pluripotency of stem cells. OCT4 splicing variants differentially expressed pluripotent and non-pluripotent Our study aims investigate expression pattern SOX-2, an essential factor implicated self-renewal pluripotency, tissue samples from patients with IBD.Peripheral were collected active CD ulcerative colitis (UC), healthy individuals. was...
Bacteriophages represent the most extensive group of viruses within human virome and have a significant impact on general health well-being by regulating bacterial population dynamics. Staphylococcus aureus , found in anterior nostrils, throat skin, is an opportunistic pathobiont that can cause wide range diseases, from chronic inflammation to severe acute infections. In this study, we developed cell-based homeostasis model between clinically isolated strain S. 141 active phages for (PYO...