A5079342565- Inflammatory Bowel Disease
- Gut microbiota and health
- Semantic Web and Ontologies
- Open Education and E-Learning
- Microscopic Colitis
- Bioinformatics and Genomic Networks
- IL-33, ST2, and ILC Pathways
- Digestive system and related health
- Viral Infections and Vectors
- E-Learning and Knowledge Management
- SARS-CoV-2 and COVID-19 Research
- Atherosclerosis and Cardiovascular Diseases
- Biomedical Text Mining and Ontologies
- Wikis in Education and Collaboration
- Insect symbiosis and bacterial influences
- Service-Oriented Architecture and Web Services
- Probiotics and Fermented Foods
- Genomics and Phylogenetic Studies
- Computational Drug Discovery Methods
- Ferroptosis and cancer prognosis
- Web and Library Services
- MicroRNA in disease regulation
- interferon and immune responses
- Animal Virus Infections Studies
- Plant Virus Research Studies
National and Kapodistrian University of Athens
2022-2025
Democritus University of Thrace
2013-2025
Hippocration General Hospital
2022
Fraunhofer Institute for Software and Systems Engineering
2015
The Open University
2015
L3S Research Center
2015
National Technical University of Athens
2011
Academy of Athens
2011
Research on interoperability of technology-enhanced learning (TEL) repositories throughout the last decade has led to a fragmented landscape competing approaches, such as metadata schemas and interface mechanisms. However, so far Web-scale integration resources is not facilitated, mainly due lack take-up shared principles, datasets schemas. On other hand, Linked Data approach emerged de-facto standard for sharing data Web offers large potential solve issues in field TEL. In this paper, we...
Even though anti-TNF therapy significantly improves the rates of remission in inflammatory bowel disease (IBD) patients, there is a noticeable subgroup patients who do not respond to treatment. Dysbiosis emerges as key factor IBD pathogenesis. The aim present study profile changes gut microbiome and transcriptome before after administration agent Infliximab (IFX) investigate their potential predict patient response IFX at baseline. Mucosal biopsy samples from 20 nine healthy controls (HC)...
The role of probiotic supplementation in type 2 diabetes (T2D) treatment is controversial. present study aimed to assess the effects a multi-strain supplement (LactoLevureR (containing Lactobacillus acidophilus, plantarum, Bifidobacterium lactis, and Saccharomyces boulardii)) over 6 months, primarily on glycemic control as well lipid levels alterations gut microbiome, among individuals with T2D residing Greece. A total 91 adults (mean age [±SD] 65.12 ± 10.92 years, 62.6% males) were...
Pancreatic cancer (PC) ranks as the seventh leading cause of cancer-related deaths, with approximately 500,000 new cases reported in 2020. Existing strategies for early PC detection primarily target individuals at high risk developing disease. Nevertheless, there is a pressing need to identify innovative clinical approaches and personalized treatments effective management. This study aimed explore dysbiosis signature fecal microbiota potential distinctions between its Intraductal papillary...
Abstract Background Ustekinumab, a monoclonal antibody targeting the p40 subunit of interleukin (IL)-12 and IL-23, is promising therapeutic approach in patients with ulcerative colitis (UC), but predicting treatment response remains challenge. In present study, we focused to identify prognostic markers ustekinumab active UC, utilizing mucosal transcriptome information machine-learning approaches. Methods We used 36 drug naive UC initiating ustekinumab. Colonic biopsies were obtained before...
Abstract Background Sphingosine-1-phosphate (S1P) receptor (S1PR) modulators (S1PRMs) block chemotaxis of cells immunity to the locus inflammation. S1PRM effectiveness depends on extent pathway activation. We explored contribution colonic stromal (CSC) S1P production in patients with ulcerative colitis (UC) and healthy controls (HC). Methods looked into two S1P-producing kinases (SPHK1, SPHK2), transporter exocytosing (SPNS2) lyase degrading it (SGPL1). Basal mRNA transcription primary CSC...
Alterations of the gut microbiome in cases colorectal cancer (CRC) hint at involvement host-microbe interactions onset and progression CRC also, possibly, provide novel ways to detect prevent early. The aim present study was evaluate whether oral fecal microbiomes an individual can be suitable for screening. Oral samples (n = 80) were gathered Taleghani hospital, affiliated with Shahid Beheshti University Medical Sciences, Tehran-Iran, from stage 0 I patients healthy controls (HCs), who...
Introduction Heart failure (HF) is a complex clinical syndrome leading to high morbidity. In this study, we aimed identify the gene expression and protein signature of HF main causes, namely dilated cardiomyopathy (DCM) ischemic (ICM). Methods Omics data were accessed through GEO repository for transcriptomic PRIDE proteomic datasets. Sets differentially expressed genes proteins comprising DCM (DiSig) ICM (IsSig) signatures analyzed by multilayered bioinformatics approach. Enrichment...
In the present study, course of SARS-CoV-2 natural infection in two asymptomatic cats, which were negative for immunosuppressive retroviral infections, is investigated. The source virus cats was their COVID-19-affected owner, with whom they continuous proximity a small household setting. owner's signs included fatigue, sneezing, anosmia and loss taste, diagnosis confirmed 4 days after symptom onset. Oropharyngeal faecal swabs collected from to investigate RNA concentrations, as well...
Abstract Mosquitoes are the most important vectors of emerging infectious diseases. During past decade, our understanding diversity viruses they carry has greatly expanded. Most these considered mosquito-specific, but there is increasing evidence that may affect vector competence mosquitoes. Metagenomics approaches have focused on specific mosquito species for identification what called core virome. Despite fact that, in ecosystems, multiple participate virus emergence and circulation, a...
Abstract Background Anti-TNF agents have been a cornerstone of IBD therapy; however, response to treatment has variable, and clinically applicable biomarkers are urgently needed. We hypothesized that the type I II interferon (IFN) signatures may be confounding factor for antitumor necrosis (TNF) via interactions with host its gut microbiota. Methods Peripheral blood from 30 patients 10 healthy controls was subjected real-time quantitative polymerase chain reaction IFN genes (IFNGs), both at...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel responsible for the disease 2019 (COVID-19) pandemic. Chains of infections starting from various countries worldwide seeded outbreak COVID-19 in Athens, capital city Greece. A full-genome analysis isolates Athens' hospitals and other healthcare providers revealed variety SARS-CoV-2 that initiated pandemic before lockdown passenger flight restrictions. dominant variant, encompassing G614D amino acid substitution, spread...
Metabolites produced by dysbiotic intestinal microbiota can influence disease pathophysiology participating in ligand–receptor interactions. Our aim was to investigate the differential expression of metabolite receptor (MR) genes between inflammatory bowel (IBD), healthy individuals (HIs), and controls order identify possible interactions with fibrotic pathways intestine. RNA-sequencing datasets containing 643 Crohn’s (CD) patients, 467 ulcerative colitis (UC) patients 295 HIs, 4...
Oncostatin-M (OSM) is associated with antitumor necrosis factor (anti-TNF)-α resistance in inflammatory bowel disease (IBD) and fibrosis diseases. We studied the expression of OSM its receptors (OSMR, gp130) on intestinal subepithelial myofibroblasts (SEMFs) effect stimulation SEMFs.
Microflora dysbiosis is implicated in the pathophysiology of Crohn’s disease. This work analyzes differences microbial communities and relevant metabolic pathways among nonstricturing nonpenetrating (B1), stricturing (B2), penetrating (B3) subphenotypes disease vs healthy controls. We conducted a bioinformatics analysis using QIIME pipeline Calypso, linear discriminant effect size, Phylogenetic Investigation Communities by Reconstruction Unobserved States, STAMP tools on publicly available...
Biting midges (Culicoides) are vectors of arboviruses both veterinary and medical importance. The surge emerging reemerging vector-borne diseases their expansion in geographical areas affected by climate change has increased the importance understanding capacity to contribute novel infectious diseases. study Culicoides virome is first step assessment this potential. In study, we analyzed RNA 10 species within area Thrace southeastern part Europe, a crossing point between Asia Europe...
Crohn's disease (CD) and Ulcerative colitis (UC) are the two main entities of inflammatory bowel (IBD). Previous works have identified more than 200 risk factors (including loci signaling pathways) in populations predominantly European ancestry. Our study was conducted on an extended population-specific cohort 573 Greek IBD patients (364 CD 209 UC) 445 controls.To highlight different genetic functional background its phenotypes, utilizing contemporary systems bioinformatics...
Introduction Extracellular matrix turnover, a ubiquitous dynamic biological process, can be diverted to fibrosis. The latter affect the intestine as serious complication of Inflammatory Bowel Diseases (IBD) and is resistant current pharmacological interventions. It embosses need for out-of-the-box approaches identify target molecular mechanisms Methods results In this study, novel mRNA sequencing dataset 22 pairs intestinal biopsies from terminal ileum (TI) sigmoid 7 patients with Crohn’s...
The social Web has become an important trend during the last few years with a thriving number of networking sites that currently address variety information needs. Following first generation human-centered networks, notion object-centered sociality been introduced to describe fact strong relationships are built mainly when individuals grouped together around shared object. In this paper we attempt further enhance object and present concept heterogeneous network, where humans objects...
Abstract Background Improving treatment outcomes with biological therapy is a demanding current need for patients inflammatory bowel disease. Discovery of pretreatment prognostic indicators response may facilitate patient selection and increase long-term remission rates. We aimed to identify baseline mucosal gene expression profiles predictive value subsequent or failure the monoclonal antibody against integrin α4β7, vedolizumab, in active ulcerative colitis (UC). Methods Mucosal 84...