A5050042998- RNA modifications and cancer
- RNA and protein synthesis mechanisms
- Insect symbiosis and bacterial influences
- Genomics and Phylogenetic Studies
- Viral Infections and Vectors
- Plant Virus Research Studies
- MicroRNA in disease regulation
- Bacterial Genetics and Biotechnology
- Cancer-related molecular mechanisms research
- Mosquito-borne diseases and control
- Immune Cell Function and Interaction
- Chronic Lymphocytic Leukemia Research
- T-cell and B-cell Immunology
- Circular RNAs in diseases
- Bacteriophages and microbial interactions
- interferon and immune responses
- Environmental DNA in Biodiversity Studies
- Infective Endocarditis Diagnosis and Management
University of Patras
2021-2024
Democritus University of Thrace
2020-2024
Abstract Mosquitoes are the most important vectors of emerging infectious diseases. During past decade, our understanding diversity viruses they carry has greatly expanded. Most these considered mosquito-specific, but there is increasing evidence that may affect vector competence mosquitoes. Metagenomics approaches have focused on specific mosquito species for identification what called core virome. Despite fact that, in ecosystems, multiple participate virus emergence and circulation, a...
Subgenomic flaviviral RNAs (sfRNAs) are small non-coding products of the incomplete degradation viral genomic RNA. They accumulate during infection and have been associated with many functional roles inside host cell. Studies so far demonstrated that sfRNA plays a crucial role in determining West Nile virus (WNV) pathogenicity. However, its modulatory on neuronal homeostasis has not studied depth. In this study, we investigated mechanism biosynthesis importance for WNV replication cells. We...
The Src family kinases (SFKs) Lck and Lyn are crucial for lymphocyte development function. Albeit tissue-restricted expression patterns the two share common functions; most pronounced one being phosphorylation of ITAM motifs in cytoplasmic tails antigenic receptors. is predominantly expressed T lymphocytes; however, it can be ectopically found B-1 cell subsets numerous pathologies including acute chronic B-cell leukemias. exact impact on signaling apparatus remains enigmatic followed by...
Abstract BackgroundMosquitoes are the most important vectors of emerging infectious diseases. During past decade, our understanding diversity viruses they carry has greatly expanded. Most these considered mosquito-specific, while there is increasing evidence that may affect mosquito vector potential. Metagenomics approaches have focused on specific species for identification what called core virome. However, in ecosystems, multiple participate virus emergence and circulation, lack...
Abstract T-box riboswitches (T-boxes) are essential RNA regulatory elements with a remarkable structural diversity, especially among bacterial pathogens. In staphylococci, all glyS T-boxes synchronize glycine supply during synthesis of nascent polypeptides and cell wall formation characterized by conserved unique insertion in their antiterminator/terminator domain, termed stem Sa. Interestingly, Staphylococcus aureus the Sa can accommodate binding specific antibiotics, which turn induce...
T-box riboswitches are widespread bacterial regulatory noncoding RNAs that directly interact with tRNAs and switch conformations to regulate the transcription or translation of genes related amino acid metabolism. Recent studies in Bacilli have revealed core mechanisms T-boxes enable multivalent, specific recognition both identity aminoacylation status tRNA substrates. However, in-depth knowledge on a vast number other species remains scarce, although remarkable structural diversity,...
Viral metagenomics, also known as virome studies, have yielded an unprecedented number of novel sequences, essential in recognizing and characterizing the etiological agent origin emerging infectious diseases. Several tools pipelines been developed, to date, for identification assembly viral genomes. Assembly often result genomes contaminated with host genetic material, some which are currently deposited into public databases. In current report, we present a group sequences that encompass...
Abstract In the era of emergence and re-emergence vector-borne diseases, a high throughput trap-based insect monitoring is essential for identification invasive species, study mosquito populations risk assessment disease outbreaks. Insect DNA metabarcoding technology has emerged as highly promising methodology unbiased large-scale surveillance. Despite significant attempts to introduce in or other surveillance qualitative quantitative remains challenge. present study, we have developed...
Abstract The Src family kinases (SFKs) Lck and Lyn are crucial for lymphocyte development function. Albeit tissue-restricted expression patterns, the two share common functions, most pronounced one, being phosphorylation of ITAM motifs in cytoplasmic tails antigenic receptors. is predominantly expressed T-lymphocytes; however, it can be ectopically found B-1 cell subsets numerous pathologies including acute chronic B-cell leukemias. exact impact on signaling apparatus remains enigmatic...