A5058460870- Hepatitis C virus research
- Insect symbiosis and bacterial influences
- Viral Infections and Vectors
- Mosquito-borne diseases and control
- Plant Virus Research Studies
- Genomics and Phylogenetic Studies
- Endoplasmic Reticulum Stress and Disease
- Systemic Lupus Erythematosus Research
- interferon and immune responses
- Neonatal Health and Biochemistry
- COVID-19 Pandemic Impacts
- Metabolism and Genetic Disorders
- Viral Infections and Immunology Research
- Hepatitis B Virus Studies
- Quality and Supply Management
- Monoclonal and Polyclonal Antibodies Research
- Drug-Induced Hepatotoxicity and Protection
- COVID-19 epidemiological studies
- Environmental DNA in Biodiversity Studies
- Bacteriophages and microbial interactions
- Quality Function Deployment in Product Design
- Occupational Health and Safety Research
- Acute Lymphoblastic Leukemia research
- Autophagy in Disease and Therapy
- Lipid metabolism and biosynthesis
Democritus University of Thrace
2017-2024
Pasteur Hellenic Institute
2017-2022
Institut Pasteur
2018
Land Quality Management
2017
University of Patras
2012
Abstract Mosquitoes are the most important vectors of emerging infectious diseases. During past decade, our understanding diversity viruses they carry has greatly expanded. Most these considered mosquito-specific, but there is increasing evidence that may affect vector competence mosquitoes. Metagenomics approaches have focused on specific mosquito species for identification what called core virome. Despite fact that, in ecosystems, multiple participate virus emergence and circulation, a...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel responsible for the disease 2019 (COVID-19) pandemic. Chains of infections starting from various countries worldwide seeded outbreak COVID-19 in Athens, capital city Greece. A full-genome analysis isolates Athens' hospitals and other healthcare providers revealed variety SARS-CoV-2 that initiated pandemic before lockdown passenger flight restrictions. dominant variant, encompassing G614D amino acid substitution, spread...
Purpose The purpose of this paper is to focus on the application quality function deployment (QFD) in a Housing Association (HA) located UK. Facing problem improving company’s performance, practitioners and academics have fashioned applied variety models, theories techniques. Design/methodology/approach research questions were developed from review process improvement literature tested using evidence field-based, action within UK HA company. case study provides insight benefits challenges...
TPMT activity is characterized by a trimodal distribution, namely low, intermediate and high methylator. gene promoter contains variable number of GC-rich tandem repeats (VNTRs), A, B C, ranging from three to nine in length an A(n)B(m)C architecture. We have previously shown that the VNTR architecture affects transcription. MATERIALS, METHODS & RESULTS: Here we demonstrate, using reporter assays, 6-mercaptopurine (6-MP) treatment results architecture-dependent decrease transcription,...
Subgenomic flaviviral RNAs (sfRNAs) are small non-coding products of the incomplete degradation viral genomic RNA. They accumulate during infection and have been associated with many functional roles inside host cell. Studies so far demonstrated that sfRNA plays a crucial role in determining West Nile virus (WNV) pathogenicity. However, its modulatory on neuronal homeostasis has not studied depth. In this study, we investigated mechanism biosynthesis importance for WNV replication cells. We...
Hepatitis C virus (HCV) possesses a second open reading frame (ORF) within the core gene encoding an additional protein, known as alternative protein (ARFP), F or core+1. The biological significance of core+1/ARF remains elusive. However, several independent studies have shown presence core+1/ARFP antibodies in chronically HCV-infected patients. Furthermore, higher prevalence was detected patients with HCV-associated hepatocellular carcinoma (HCC). Here, we investigated incidence...
Intergenotypic recombinant hepatitis C virus (HCV) strains emerge rarely during coinfection of the same individual with two HCV genotypes. Few have been identified to date and only one, CRF01 2k/1b, has become a worldwide concern. This study reevaluated genotyping three genotype 2 from group patients an unusually low rate sustained virological response after pegylated interferon/ribavirin treatment. In addition, genetic determinants host interferon resistance were evaluated.The type...
Abstract BackgroundMosquitoes are the most important vectors of emerging infectious diseases. During past decade, our understanding diversity viruses they carry has greatly expanded. Most these considered mosquito-specific, while there is increasing evidence that may affect mosquito vector potential. Metagenomics approaches have focused on specific species for identification what called core virome. However, in ecosystems, multiple participate virus emergence and circulation, lack...
Hepatitis C virus (HCV) core protein is a multifunctional that involved in proliferation, inflammation and apoptosis mechanism of hepatocytes. HCV genetic variability has been implicated various outcomes pathology treatment. In the present study, we aimed to analyze role tumor necrosis factor α (TNFα)-induced death under viewpoint variability. Immortalized hepatocytes (IHH), not Huh7.5 hepatoma cell line, stably expressing subtype 4a 4f proteins showed only could increase...
Hepatitis C virus (HCV) core protein is a multifunctional that involved in the proliferation, inflammation, and apoptosis mechanism of hepatocytes. HCV genetic variability has been implicated various outcomes pathology treatment. In present study, we aimed to analyze role tumor necrosis factor α (TNFα)-induced death under viewpoint variability. Immortalized hepatocytes (IHH), not Huh 7.5 hepatoma cell line, stably expressing subtype 4a 4f proteins showed only could increase sensitivity...
Viral metagenomics, also known as virome studies, have yielded an unprecedented number of novel sequences, essential in recognizing and characterizing the etiological agent origin emerging infectious diseases. Several tools pipelines been developed, to date, for identification assembly viral genomes. Assembly often result genomes contaminated with host genetic material, some which are currently deposited into public databases. In current report, we present a group sequences that encompass...
Abstract In the era of emergence and re-emergence vector-borne diseases, a high throughput trap-based insect monitoring is essential for identification invasive species, study mosquito populations risk assessment disease outbreaks. Insect DNA metabarcoding technology has emerged as highly promising methodology unbiased large-scale surveillance. Despite significant attempts to introduce in or other surveillance qualitative quantitative remains challenge. present study, we have developed...