A5050460607- Plant Virus Research Studies
- Bacteriophages and microbial interactions
- CRISPR and Genetic Engineering
- Microbial infections and disease research
- Cancer Genomics and Diagnostics
- interferon and immune responses
- Lung Cancer Treatments and Mutations
- Viral Infections and Vectors
- Antimicrobial Resistance in Staphylococcus
- Cholangiocarcinoma and Gallbladder Cancer Studies
- SARS-CoV-2 and COVID-19 Research
- Viral Infections and Outbreaks Research
- HIV Research and Treatment
- RNA and protein synthesis mechanisms
- Lung Cancer Research Studies
- HIV/AIDS drug development and treatment
- Mosquito-borne diseases and control
- Cancer-related molecular mechanisms research
- Fungal Infections and Studies
- Antifungal resistance and susceptibility
Children's Healthcare of Atlanta
2024
Emory University
2024
Democritus University of Thrace
2021-2024
Candida auris has recently emerged as a multidrug-resistant yeast implicated in various healthcare-associated invasive infections and hospital outbreaks. In the current study, we report first five intensive care unit (ICU) cases affected by C. isolates Greece, during October 2020–January 2022. The ICU of was converted to COVID-19 on 25 February 2021, third wave Greece. Identification confirmed Matrix Assisted Laser Desorption Ionization Time Flight mass spectroscopy (MALDI-TOF]. Antifungal...
Abstract Therapeutic regimens for the COVID‐19 pandemics remain unmet. In this line, repurposing of existing drugs against known or predicted SARS‐CoV‐2 protein actions have been advanced, while natural products also tested. Here, we propose that p‐cymene, a monoterpene, can act as potential novel agent treatment SARS‐CoV‐2‐induced and other RNA‐virus‐induced diseases (influenza, rabies, Ebola). We show by extensive molecular simulations C‐terminal structured domain contains nuclear...
Background/Aim: The plasma levels of cell-free DNA (cfDNA) in cancer patients increase due to rapid cell proliferation and death. Therefore, cfDNA can be used study specific tumor-DNA features. In addition, the non-specific concentration may an important biomarker prognosis. Patients Methods: We prospectively examined predictive role kinetics outcome chemo-radiotherapy (CRT) a cohort 47 with locally advanced squamous head-neck (SCHNC) treated definitive chemo-radiotherapy. Results: Increased...
Subgenomic flaviviral RNAs (sfRNAs) are small non-coding products of the incomplete degradation viral genomic RNA. They accumulate during infection and have been associated with many functional roles inside host cell. Studies so far demonstrated that sfRNA plays a crucial role in determining West Nile virus (WNV) pathogenicity. However, its modulatory on neuronal homeostasis has not studied depth. In this study, we investigated mechanism biosynthesis importance for WNV replication cells. We...
Disruption of HIV-1 Integrase (IN) interactions with the host-factor Lens Epithelium-Derived Growth Factor (LEDGF)/p75 leads to decreased, random integration, increased latent infection, and described here, accumulation antisense RNA (asRNA). asRNA increase was observed following interruptions IN-LEDGF/p75 either through pharmacologic perturbations by treatment allosteric integrase inhibitors (ALLINIs) or in cell lines LEDGF genetic knockout. Additionally, impairing Tat-dependent HIV...
Using next-generation sequencing (NGS), we investigated DNA mutations in the plasma tumor cell-free circulating (ctDNA) of 38 patients with inoperable squamous cell head neck cancer (SCHNC) before and after completion chemoradiotherapy (CRT). Baseline TP53 were recorded 10/38 (26.3%) persisted 4/10 CRT. ΤP53 further detected post CRT 7/38 additional undetectable at baseline (overall rate 44.7%). Furthermore, 4/38 exhibited EGFR, AR, FGFR3, FBXW3, four new gene (MTOR, EGFR3, ALK, SF3B1). Τ4...
Escherichia Coli ( E. coli ) is one of the most prevalent bacteria in gut and plays an important role formation intestinal microbiome. In this study, phage Ioannina, a novel member Caudoviricetes , with high lytic activity against ATCC 25922, was isolated from hospital wastewater. Ioannina highly resistant to broad range temperatures alkaline pH, but sensitive acidic pH. Whole genome sequencing phage, revealed that within Dhillonvirus genus. Its 45,270 bp double-stranded DNA molecule encodes...
Escherichia Coli ( E. coli ) is one of the most prevalent bacteria in gut and plays an important role formation intestinal microbiome. In this study, phage Ioannina, a novel member Caudoviricetes , with high lytic activity against ATCC 25922, was isolated from hospital wastewater. Ioannina highly resistant to broad range temperatures alkaline pH, but sensitive acidic pH. Whole genome sequencing phage, revealed that within Dhillonvirus genus. Its 45,270 bp double-stranded DNA molecule encodes...