A5029300111- Ear Surgery and Otitis Media
- Bacterial Infections and Vaccines
- Pneumonia and Respiratory Infections
- Respiratory and Cough-Related Research
- Respiratory viral infections research
- Streptococcal Infections and Treatments
- Sinusitis and nasal conditions
- Otitis Media and Relapsing Polychondritis
- Congenital Ear and Nasal Anomalies
- Pediatric health and respiratory diseases
- Nasal Surgery and Airway Studies
- Tracheal and airway disorders
- Microbial infections and disease research
- Otolaryngology and Infectious Diseases
- Antimicrobial Peptides and Activities
- Health and Medical Studies
- Immune Response and Inflammation
- Peptidase Inhibition and Analysis
- Influenza Virus Research Studies
- Animal Genetics and Reproduction
- Ear and Head Tumors
- Medical and Health Sciences Research
- RNA Interference and Gene Delivery
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Infection Control and Ventilation
Lund University
2013-2024
Skåne University Hospital
2010-2024
House Clinic
2005
Uppsala University
2000
Umeå University
1988-1990
Abstract Background Bacterial meningitis is a rare, but life-threatening disease, which sometimes occurs as complication to acute otitis media (AOM). The proportion of cases originating from AOM not clear. Purpose aim this study was investigate the caused by AOM, compare risk factors, bacteriology and outcome between otogenic non-otogenic meningitis, analyse incidence bacterial after introduction conjugate pneumococcal vaccines (PCV). Methods medical charts all patients admitted hospitals in...
A mutant lacking the ability to express surface-exposed lipoprotein protein D was constructed by linker insertion and deletion mutagenesis of a cloned DNA insert containing structural gene from nontypeable Haemophilus influenzae strain (NTHi). An isogenic NTHi isolated after transformation genetically competent bacteria. The transformant unreactive D-specific monoclonal antibody in colony immunoassay. In addition, lacked synthesize detectable levels staining, immunoblot methods,...
Background It has become clear that healthcare workers are at high risk, and otolaryngology been theorized to be among the highest risk specialties for coronavirus disease 2019 (COVID‐19). The purpose of this study was detail international impact COVID‐19 otolaryngologists, identify instructional cases. Methods Country representatives Young Otolaryngologists–International Federation Otolaryngologic Societies (YO‐IFOS) surveyed otolaryngologists through various channels. Nationwide surveys...
Hearing loss is a common sequela after bacterial meningitis, but risk factors for this are poorly studied, particularly in relation to concurrent acute otitis media (AOM).The aim of study was investigate incidence and hearing patients treated meningitis.In retrospective study, medical records admitted hospital with meningitis Skåne county, Sweden, between 2000 2017 were retrieved. The association estimated using logistic regression.During the 18 years, 187 cases identified. confirmed 71 119...
Abstract Aim: Acute otitis media (AOM) is a common childhood disease, which often becomes recurrent (rAOM). A small reduction in AOM episodes has been noted unselected child cohorts after vaccination with heptavalent conjugate pneumococcal vaccine (PCV7). The purpose of this study was to investigate how affects young children at risk developing rAOM. Methods: Ninety‐six an onset before 6 months age, implying high for rAOM, were closely monitored until the age 2 years. Forty‐six vaccinated...
Conclusion: Risk factors associated with increased carriage rates are the same in children recurrent acute otitis media (rAOM) as healthy children. These also known to be risk for development of AOM itself. Objectives: The aim this study was describe nasopharyngeal a cohort young at high developing rAOM. Methods: Children an onset before 6 months age, indicating 80% rAOM, were enrolled vaccination trial on heptavalent PCV. monitored 3 years during and periods cultures, physical examinations,...
To examine the effect of a transient episode purulent AOM on middle ear mucosa, an animal model was used. Histological examination performed after inoculation pneumococci into rat ear. At 4, 8 and 12 days, at 2 months inoculation, rats were sacrified each occasion samples taken from specific areas mucosa. Structural alterations noted all mucosal sites. The normally flat epithelium had become more cuboidal or cylindrical, numerous ciliated cells occurred in originally devoid these cells....
Essential oils are volatile and can have good antimicrobial activity. We compared the effects of oil basil (Ocimum basilicum) essential components (thymol, carvacrol, salicylaldehyde) to those a placebo when placed in ear canal rats with experimental acute otitis media caused by pneumococci or Haemophilus influenzae. Progress was monitored otomicroscopic examination middle cultures. The treatment cured healed 56%-81% infected H. influenzae 6%-75% pneumococci, 5.6%-6% group. their provide...
Middle ears of male Sprague-Dawley rats were injected with suspensions thirteen Haemophilus influenzae strains different sero- and biotypes at various concentrations. Systemic local changes monitored by clinical observations, otomicroscopy, analysis bacterial samples from blood middle ears. Two patterns response recognized, a nontypeable an encapsulated pattern. The H. ear infection required high dose was well past its peak 8 days after challenge, when the otitis media still purulent. most...
Conclusions: Recurrences were seen in 5% of all patients with acute mastoiditis (AM). Mastoidectomy had been performed the majority recurrences at their first episode AM. Compared group a single AM, recurrent exhibited more subperiosteal and ear canal abscesses, although they not severely ill. It appears from this study that previous mastoidectomy itself could predispose to AM (rAM), perhaps due easier access mastoid cavity and/or reduction mucosal lining. Objective: To retrospectively...
To investigate the internal validity of diagnosis code used at discharge after treatment acute mastoiditis.Retrospective national re-evaluation study patient records 1993-2007 and make comparison with original ICD codes.All ENT departments university hospitals one large county hospital department in Sweden.A total 1966 were reviewed for patients codes in-patient (529), chronic (44) unspecified mastoiditis (21) otitis media (1372).ICD by authors a defined protocol clinical mastoiditis. Those...
AbstractWe examined the mucosa of 50 rat middle Cars in an experimental model acute otitis media, order to obtain information on mechanisms polyp formation- The right Car 25 rats was inoculated with type 3 pneumococci. and left served as a control. animals were killed, bulla removed, dissected from bone, stained PAS-alcian blue embedded whole-mount. whole-mounts light microscope for polypous mucosal prominences. Serial sections made all polyps, relevant parts mucosa. 15 polyps found II (44%)...
Magnuson K, Hermansson A, Melhus Å, Hellström S. The tympanic membrane and middle ear mucosa during non-typeable Haemophilus influenzae type b acute otitis media. A study in the rat. Acta Otolaryngol (Stockh) 1997; 117: 396-405.Non-typeable (NTHi) encapsulated (Hib) were inoculated into ears of Sprague-Dawley rats. Tympanic (TM) status was assessed otomicroscopically specimens from various areas prepared for light microscopy at times phase up to 6 months after inoculation. Irrespective...
An experimental rat model for Streptococcus pneumoniae otitis media was used to investigate passive protection by anti-type 3 capsular antibodies and effects of immunization with pneumococcal surface protein A (PspA). Anti-type instilled into the middle ear reduced purulent as compared control animals (p = 0.015). Secondly, after PspA, right inoculated S. type 6A in a dose calibrated induce media. There an anti-PspA antibody response all rats immunized reduction signs 0.026). Thus, (acute)...
To study the effects of viable and heat-killed Moraxella catarrhalis bacteria on middle ear mucosa to evaluate protection after whole-cell immunizations, Sprague-Dawley rats were challenged rechallenged with four different M. strains. The animals monitored by clinical observations, bacterial histological samples from ears, serum IgG levels. Only at a high concentration induced purulent otitis media, which was culture positive in 58% cases day 4. infection characterized mild acute reaction...
The purpose of our study was to elucidate the course healing tympanic membrane (TM) when myringotomy performed during acute otitis media. early and long-lasting structural changes TM were studied in an animal model. Rats inoculated with Streptococcus pneumoniae (PnC) type 3 bulla. When infection manifest, performed. On days 4 12, 6 months after myringotomy, status checked by otomicroscopy TMs prepared for light electron microscopy. Comparison made PnC-infected that not perforated, as well...
The diagnosis of acute otitis media (AOM) is often difficult, depending heavily on the experience and skills examiner. However, it important to identify episodes AOM that involve risk complications treat these appropriately. present study was performed in order evaluate use a rapid antigen assay for Streptococcus pneumoniae, Binax NOW test, as diagnostic tool patients with severe associated complications. included 70 74 AOM, 18 them Cultures, tests, PCR were nasopharyngeal secretions, middle...