Poor oocyte quality is a main concern for decreased reproductive outcomes in women with polycystic ovarian syndrome (PCOS) during controlled hyperstimulation (COH). A primary way to improve optimize the COH protocol. It was demonstrated that viable embryo rate per retrieved Utrogestan and hMG protocol, novel regimen based on frozen-thawed transfer (FET), statistically higher than short Thus, retrospective study conducted evaluate endocrine characteristics clinical PCOS patients subjected...

Abstract Human amniotic epithelial cells (hAECs) have shown excellent efficacy in clinical research and prospective applications the treatment of many diseases. However, properties hAECs their proliferative mechanisms remain unclear. Here, single‐cell RNA sequencing (scRNA‐seq) is performed on obtained from tissues at different gestational ages passages during vitro culture. The results showed that proliferation associated with epithelial‐mesenchymal plasticity (EMP) amniogenesis. Freshly...

Polycystic ovarian syndrome (PCOS) is a common endocrine and metabolic disorder in women of reproductive age. In this study, we aimed to investigate the potential prognostic value mitophagy-related genes PCOS patients analyze their role immune infiltration during pathogenesis progression. Training datasets were used for differential expression genes. Gene ontology annotations Kyoto encyclopedia genomes signaling pathway enrichment analysis performed. The biomarkers screened by...

Abstract Early embryonic arrest is one of the major causes recurrent assisted reproduction failure. It characterized by delayed development and failure to form viable eight‐cell stage embryos on day 3 an cycle. A recent study reported that biallelic mutations in NLRP5 can cause early arrest. a member subcortical maternal complex, which plays significant role embryogenesis. In this study, we described female consanguineous Chinese family who displayed clinical features identified novel...

Early embryonic arrest denotes premature termination of development in preimplantation embryos, which is one the major phenotypes recurrent assisted reproduction failure. Padi6 proven to be a member subcortical maternal complex (SCMC) mice, essential oocyte maturation and embryogenesis. We other groups previously found that biallelic mutations PADI6 caused female infertility manifesting as early arrest. In this study, we identified two novel homozygous variants (p.Cys163Arg, p. Trp475*)...

This study aimed to evaluate the cumulative live birth rate (cLBR) of progestin-primed ovarian stimulation (PPOS) protocol versus gonadotropin-releasing hormone antagonist (GnRH-ant) for in vitro fertilization (IVF) cycle infertile women with normal reserve (NOR). Infertile NOR who underwent their first IVF were enrolled an open-label randomized controlled trial. Patients randomly assigned 1:1 receive a freeze-all strategy delayed embryo transfer (PPOS group, n = 174) and fresh (GnRH-ant...

Endometriosis, the presence of active endometrial tissue outside lining membrane uterine cavity, is a common disease in women childbearing age. The ectopic endometrium has some characteristics tumor tissue, including invasive and migratory abilities. In addition, endometriosis associated with inflammation reduced cellular apoptosis.Western blot analysis, qPCR, immunohistochemistry, immunofluorescence microscopy, Transwell assay, wound healing TUNEL staining.Interleukin-1β (IL-1β) induced...

Abstract Progesterone soft capsules (brand name: Utrogestan) were demonstrated to be an effective oral alternative prevent premature LH surges both in normal-ovulatory and polycystic ovarian syndrome (PCOS) patients. However, its safety terms of neonatal outcomes is unclear. To evaluate whether Utrogestan use increase the risk adverse compared with short protocol patients undergoing IVF/ICSI treatments combination frozen-thawed embryo transfer (FET), we performed a retrospective analysis...

Polycystic ovary syndrome (PCOS) is an endocrinopathy with complex pathophysiology that a common cause of anovulatory infertility in women. Although the disruption circadian rhythms indicated PCOS, role clock etiology these pathologies has yet to be appreciated. The nuclear receptors REV-ERBα and REV-ERBβ are core modulators participate regulation diverse set biological functions. However, expression REV-ERBs their effects remain unclear. Here, we demonstrate levels were lower granulosa...

Oral progestin has recently been used to prevent premature LH surges in ovarian stimulation, and this progestin-primed stimulation (PPOS) is effective safe patients with different reserves. The current data are lacking regarding how individualize the gonadotropin dose regimen for women polycystic syndrome (PCOS). A retrospective cohort trial was performed evaluate efficacy of milder clomiphene citrate (CC) compared standard protocol infertile PCOS. total 220 PCOS were collected classified...

Background: Exogenous progestational agents have recently been introduced as an alternative pituitary modulator for the prevention of premature luteinizing hormone (LH) surges during in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) treatments. There is increasing evidence that frozen-embryo transfer (FET) associated with a lower risk ovarian hyperstimulation syndrome (OHSS) women polycystic ovary (PCOS). Herein, we compared clinical outcomes progesterone protocol...

Stoichiometric 1 : reaction of C60 with potassium mediated by 1-methylnaphthalene in THF at room temperature produces KC60(THF) high yields; VIS-near IR, FTIR, solid-state 13C NMR and ESR spectra the product are reported.

Timing of frozen embryo transfer (FET) in natural endometrial preparation cycles is often based on luteinizing hormone (LH) surge. However, some patients do not show spontaneous LH surge despite follicular maturation. The objective this study was to evaluate the impact pregnancy outcomes modified (mNC).This retrospective analysis included 1897 FET with normo-ovulatory women between January 1, 2015, December 31, 2019, at our center: 920 (≥ 20 IU/L) and 977 without. For cleavage embryos,...

This letter reports the far-infrared (FIR) transmission spectra of undoped and Sb-doped p-type Hg1−xCdxTe films grown by a liquid-phase epitaxy (LPE) or molecular-beam (MBE) technique. The activation energies cation vacancy acceptor are found to be ∼10–12 meV almost independent on Cd composition. absorption strength per Hg vacancy, useful for evaluating density from spectra, is derived as 3.4×10−12 cm. Further, Zeeman splitting resulting two different acceptors observed magnetotransmission...

Abstract Background Low serum progesterone on the day of frozen embryo transfer (FET) is associated with diminished pregnancy rates in artificial endometrium preparation cycles, but there no consensus whether strengthened luteal phase support (LPS) benefits patients low FET cycles. This single-centre, large-sample retrospective trial was designed to investigate contribution LPS outcomes for groups levels Methods Women who had undergone first cycle after a freeze-all protocol our clinic from...

Polycystic ovary syndrome (PCOS) is one of the most common hormonal disorders among premenopausal women. PCOS accompanied by many other reproductive, endocrinal, and metabolic thus amassing difficulties encountered women affected. However, there limited information on its molecular etiology. Synoviolin (SYVN1) an E3 ubiquitin ligase that thought to participate in pathology PCOS. expression function SYVN1 are unknown. In this study, we found downregulation was followed increased apoptosis...

The superconducting energy gap of the high-${T}_{c}$ superconductor $\mathrm{Y}{\mathrm{Ba}}_{2}{\mathrm{Cu}}_{3}{\mathrm{O}}_{9\ensuremath{-}\ensuremath{\delta}}$ (${T}_{c}=90$ K) has been measured by far-infrared technique in frequency range 30-150 ${\mathrm{cm}}^{\ensuremath{-}1}$ and temperature 4.2-200 K. frequency-dependent reflectances two different samples show a common feature near ${\ensuremath{\omega}}_{c}\ensuremath{\approx}125$ where reflectance curves drop rapidly at very low...

The present study aimed to evaluate pregnancy and neonatal outcomes in women, with a previous history of wedge resection for interstitial pregnancy, frozen-thawed embryo transfer (FET) cycles IVF/ICSI.The involved retrospective case-control assessment 75 cases 375 control subjects over 6 years single center. To compare between cases, treated using resection, controls without any ectopic propensity score matching (1:5) was utilized. also compared subgroups the case group.Women exhibited...

<title>Abstract</title> <bold>Background:</bold> Endometriosis is a common disease among women of childbearing age. However, the molecular mechanism behind it still unknown. Therefore, new biomarkers and therapeutic targets are needed to improve diagnosis treatment infertile women. <bold>Methods:</bold> Microarray datasets GSE7305, GSE7307, GSE51981 were downloaded from Gene Expression Omnibus (GEO) database identify differentially expressed genes (DEGs) between control endometriosis. The...

This letter discusses the analysis of infrared and visible spectra Hg1−xCdxTe thin films deposited by molecular beam epitaxy (MBE) onto a CdTe buffer layer on GaAs substrate. The were obtained transmission spectroscopic ellipsometry. Two mathematical techniques, fast Fourier transform (FFT) multiple reflectance spectrum associated with multilayer system fractional-derivatives (FDS) employed. Compared to conventional fitting procedure, FFT method directly offers thickness individual layers....