A5065431996- Heat Transfer and Optimization
- Heat Transfer and Boiling Studies
- Refrigeration and Air Conditioning Technologies
- Immunotherapy and Immune Responses
- Greenhouse Technology and Climate Control
- Solar-Powered Water Purification Methods
- Adsorption and Cooling Systems
- RNA Interference and Gene Delivery
- T-cell and B-cell Immunology
- Cell Adhesion Molecules Research
- Cancer-related Molecular Pathways
- Geothermal Energy Systems and Applications
- Immune Response and Inflammation
- Head and Neck Cancer Studies
- Gene Regulatory Network Analysis
- Cancer Genomics and Diagnostics
- Mathematical Biology Tumor Growth
- Nanofluid Flow and Heat Transfer
- Monoclonal and Polyclonal Antibodies Research
- Diffusion and Search Dynamics
- Thermodynamic and Exergetic Analyses of Power and Cooling Systems
- Heat Transfer Mechanisms
- Building Energy and Comfort Optimization
- Neuroinflammation and Neurodegeneration Mechanisms
- Immune Cell Function and Interaction
Libera Università Maria SS. Assunta
2022-2025
LUM Jean Monnet University
2023
University of Bari Aldo Moro
2021
University of Salento
2006-2020
Innovation Engineering (Italy)
2003-2015
National Research Council
1996-2013
Istituto di Farmacologia Traslazionale
2013
Institute of Neurobiology and Molecular Medicine
2003-2010
Istituto Nazionale di Fisica Nucleare, Sezione di Lecce
2005-2006
Istituto di Fisiologia Clinica
1990-2005
The p53-inducible gene PC3 (TIS21, BTG2) is endowed with antiproliferative activity. Here we report that expression of in cycling cells induced accumulation hypophosphorylated, growth-inhibitory forms pRb and led to G(1) arrest. This latter was not observed genetic disruption the Rb gene, indicating PC3-mediated arrest dependent. Furthermore, (i) G(1)-S transition exerted by completely rescued coexpression cyclin D1 but A or E; (ii) caused a significant down-regulation protein levels, also...
Abstract Fas/Apo-1 molecule, also designated as CD95, is a member of the TNF receptor family. Fas cross-linking by its natural ligand or agonistic mAbs results in rapid induction apoptosis susceptible cells. addition to full-length mRNA, human activated PBMC and tumor cell lines express several mRNA variants that derive from alternative splicing primary transcript. All five identified, two which are newly described here, code for soluble proteins that, with exception FasTMDel, truncated...
Tumor necrosis factor α (TNF-α) is a cytokine implicated in the pathogenesis of numerous chronic and acute inflammatory conditions. We have previously shown that mouse Sertoli cells respond to TNF-α by increasing interleukin-6 production intercellular adhesion molecule-1 (ICAM-1) expression (1Riccioli A. Filippini De Cesaris P. Barbacci E. Stefanini M. Starace G. Ziparo Proc. Natl. Acad. Sci. U. S. 1995; 92: 5808-5812Crossref PubMed Scopus (89) Google Scholar). In this cell type activates...
The expression of the cell adhesion molecules ICAM-1, ICAM-2, and VCAM-1 secretion cytokine interleukin 6 have been measured in mouse Sertoli cells cultured vitro. Cytometric analysis revealed that, basal conditions, low levels ICAM-1 were present on surface cells, whereas treatment with 1, tumor necrosis factor alpha, lipopolysaccharide, or interferon gamma induced, different kinetics, increases their expression. ICAM-2 was not detectable nor it inducible. Electron microscopic binding...
Mitogen-activated protein kinase 3 (MAP2K3) is a member of the dual specificity group. Growing evidence links MAP2K3 to invasion and tumor progression. Here, we identify as transcriptional target endogenous gain-of-function p53 mutants R273H, R175H, R280K. We show that modulation occurred at mRNA levels mutant proteins are capable binding activate promoter. In addition, found studied regulate gene expression through involvement cofactors NF-Y NF-κB. Finally, functional studies showed...
In the current scenario of transition to a Europe-wide circular economy (CE), Waste-to-Energy (WtE) treatments represent smart solution generate renewable energy, reduce landfills and ensure sustainable waste management. The costs environmental impacts existing WtE are very different for each available technology. many cases, their identification is affected by set variable boundary conditions strongly dependent on local municipal requirements. light these considerations, paper aims compare...
The production process of extra virgin olive oil, which is a strategic asset the Italian agrifood sector, can be innovated in its impact on environment, according to dual approach: (a) with view circular economy, acting waste it produces, either correctly disposing or effectively reusing it, and (b) emissions, reducing carbon footprint that generates, starting from supply chain. This approach, clearly contributing economy paradigm achievement zero-emission requires sector make significant...
Sertoli cells have long been considered to be involved in the regulation of immune response testis. More recently, Fas system has implicated maintenance privilege testis as well germ cell apoptosis. However, control and ligand (FasL) expression remains unknown. In present study, we demonstrate that cultured mouse constitutively express a low level membrane-bound protein, but not soluble form Fas. stimulated with TNF-alpha IFN-gamma markedly increase both dose-dependent manner. The...
The phosphatidylinositol 3-kinase/AKT pathway is activated frequently in human cancer, and it has been implicated tumor cell proliferation, survival, chemoresistance. In this study, we addressed the role of AKT cellular responses to therapeutic methylating agent temozolomide (TMZ), investigated possible link between TMZ-induced modulation function activation ataxia-telangiectasia Rad3-related (ATR)- ataxia telangiectasia mutated (ATM)-dependent signaling pathways. We found that clinically...
A new innovative infusion technology, pulsed infusion, has been developed for the manufacturing of fiber-reinforced thermoset-based composites. Pulsed is a double-bag vacuum process that based on use proper designed reusable pressure distributor and able to better control in way. Thus, transverse resin flow through dry fiber reinforcement promoted adhesion between fibers achieved. The allows obtain laminates with same volume fraction tensile properties those produced by conventional...
An increasing number of malignancies has been shown to be initiated and propelled by small subpopulations cancer stem cells (CSC). However, whether tumor aggressiveness is driven CSC what extent this property may relevant within the mass still unsettled. To address issue, we isolated a rare cell population on basis its CD44(+)CD24(-) phenotype from human androgen-independent prostate carcinoma line DU145 established properties. The behavior selected was investigated with respect bulk cells....