A5078870622- Neurobiology and Insect Physiology Research
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Antioxidant Activity and Oxidative Stress
- Plant biochemistry and biosynthesis
- Pharmacogenetics and Drug Metabolism
- Innovative Microfluidic and Catalytic Techniques Innovation
- Digital Holography and Microscopy
- Analytical Chemistry and Chromatography
- Gout, Hyperuricemia, Uric Acid
- Drug-Induced Hepatotoxicity and Protection
- Metabolomics and Mass Spectrometry Studies
- Insect-Plant Interactions and Control
- Estrogen and related hormone effects
- Insect Resistance and Genetics
- Drug Solubulity and Delivery Systems
- Microfluidic and Capillary Electrophoresis Applications
Novartis (Switzerland)
2018
Chugai Pharma (United States)
2018
Pfizer (United States)
2018
Roche (United States)
2018
Boehringer Ingelheim (Switzerland)
2018
The University of Tokyo
2011-2018
Roche (Switzerland)
2018
Bristol-Myers Squibb (Germany)
2018
In insects, the precise timing of moulting and metamorphosis is strictly guided by ecdysteroids that are synthesised from dietary cholesterol in prothoracic gland (PG). past decade, several ecdysteroidogenic enzymes, some which encoded Halloween genes, have been identified characterised. Here, we report a novel gene, noppera-bo (nobo), encodes member glutathione S-transferase family. nobo was as gene predominantly expressed PG fruit fly Drosophila melanogaster. We generated knock-out mutant,...
UR-1102, a novel uricosuric agent for treating gout, has been confirmed to exhibit pharmacological effect in patients. We clarified its metabolic pathway, estimated the contribution of each enzyme, and assessed impact genetic polymorphisms using human vitro materials.Glucuronide, sulfate oxidative metabolites UR-1102 were detected hepatocytes.The intrinsic clearance by glucuronidation or oxidation liver microsomes was comparable, but sulfation cytosol much lower, indicating that rank order ≥...