A5038309889- Gastric Cancer Management and Outcomes
- COVID-19 epidemiological studies
- COVID-19 Pandemic Impacts
- Colorectal Cancer Screening and Detection
- Gastrointestinal Tumor Research and Treatment
- Esophageal Cancer Research and Treatment
- Esophageal and GI Pathology
- Bioinformatics and Genomic Networks
- Metastasis and carcinoma case studies
- Gene expression and cancer classification
- Colorectal Cancer Surgical Treatments
- SARS-CoV-2 and COVID-19 Research
- COVID-19 impact on air quality
- COVID-19 Clinical Research Studies
- Diverticular Disease and Complications
- Computational Drug Discovery Methods
- Pancreatic and Hepatic Oncology Research
- Dysphagia Assessment and Management
- Helicobacter pylori-related gastroenterology studies
- SARS-CoV-2 detection and testing
- Genetic factors in colorectal cancer
- Tracheal and airway disorders
- Metabolomics and Mass Spectrometry Studies
- Cancer, Lipids, and Metabolism
- Gene Regulatory Network Analysis
Michigan Center for Translational Pathology
2024-2025
University of Michigan
2019-2025
North Middlesex Hospital
2022-2023
Middlesex University
2023
Michigan United
2023
The Japanese Society of Gastroenterological Surgery
2023
Hiroshima University Hospital
2023
Iwate Medical University
2023
Hudson Institute
2023
Queen Alexandra Hospital
2014-2022
With only 536 COVID-19 cases and 11 fatalities, India took the historic decision of a 21-day national lockdown on March 25, 2020. The was first extended to May 3 soon after analysis this article completed, then 18 while being revised. In article, we use Bayesian extension susceptible-infected-removed (eSIR) model designed for intervention forecasting study short- long-term impact an initial total number infections in compared other, less severe nonpharmaceutical interventions. We compare...
Objectives To evaluate the effect of four-phase national lockdown from March 25 to May 31 in response COVID-19 pandemic India and unmask state-wise variations terms multiple public health metrics. Design Cohort study (daily time series case counts). Setting Observational population based. Participants Confirmed cases nationally across 20 states that accounted for >99% current cumulative counts until 2020. Exposure Lockdown (non-medical intervention). Main outcomes measures We illustrate...
Abstract Importance India has taken strong and early public health measures for arresting the spread of COVID-19 epidemic. With only 536 cases 11 fatalities, – a democracy 1.34 billion people took historic decision 21-day national lockdown on March 25. The was further extended to May 3rd, soon after analysis this paper completed. Objective To study short- long-term impact an initial total number in compared other less severe non-pharmaceutical interventions using epidemiological forecasting...
Abstract India has seen a surge of SARS-CoV-2 infections and deaths in early part 2021, despite having controlled the epidemic during 2020. Building on two-strain, semi-mechanistic model that synthesizes mortality genomic data, we find evidence altered epidemiological properties B.1.617.2 (Delta) variant play an important role this resurgence India. Under all scenarios immune evasion, increased transmissibility advantage for B.1617.2 against previously circulating strains. Using extended SIR...
Abstract Background and study aims Up to 25 % colorectal adenomas are missed during colonoscopy. The aim of this was investigate whether the endocuff could improve polyp detection in an organized bowel cancer screening program (BCSP). Patients methods This parallel group, single-blinded, randomized controlled trial included patients with positive fecal occult blood test (FOBT) who were attending for BCSP primary outcome number polyps per patient. Secondary outcomes patient, adenoma rates,...
Abstract Background Many popular disease transmission models have helped nations respond to the COVID-19 pandemic by informing decisions about planning, resource allocation, implementation of social distancing measures, lockdowns, and other non-pharmaceutical interventions. We study how five epidemiological forecast assess course in India: a baseline curve-fitting model, an extended SIR (eSIR) two SEIR (SAPHIRE SEIR-fansy) models, semi-mechanistic Bayesian hierarchical model (ICM). Methods...
India experienced a massive surge in SARS-CoV-2 infections and deaths during April to June 2021 despite having controlled the epidemic relatively well 2020. Using counterfactual predictions from epidemiological disease transmission models, we produce evidence support of how strengthening public health interventions early would have helped control country significantly reduced mortality second wave, even without harsh lockdowns. We argue that enhanced surveillance at district, state, national...
Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) have shown a significant global increase over the past decade. The mTOR signaling pathway is positive regulator of cell cycle progression, with its activation playing key role in pathogenesis NETs. Since 2011, FDA-approved inhibitor everolimus has been used as an anti-tumor agent for treating progressive NETs, and clinical efficacy limited due to rapid disease relapse progression. In this study, we investigated autophagy, specifically...
<b>Background and study aims:</b> There have been significant advances in the management of complex colorectal polyps. Previous failed resection or polyp recurrence is associated with fibrosis, making endoscopic extremely challenging; traditional approach to these lesions surgery. The aim this was evaluate efficacy a novel, knife-assisted snare (KAR) technique scarred colonic <b>Patients methods:</b> This prospective cohort patients, whom KAR used resect polyps > 2 cm size. Patients had...
Pancreatic ductal adenocarcinoma (PDAC) subsists in a nutrient-deregulated microenvironment, making it particularly susceptible to treatments that interfere with cancer metabolism
<b>Background and study aims: </b>Mucosal views can be impaired by residual bubbles mucus during gastroscopy. This aimed to determine whether a pre-gastroscopy drink containing simethicone N-acetylcysteine improves mucosal visualisation. <b>Patients methods: </b>We conducted randomized controlled trial recruiting 126 subjects undergoing routine Subjects were 1:1:1 receive: A—pre-procedure of water, (NAC); B—water alone; or C—no preparation. Study endoscopists blinded group allocation....
BackgroundScreening for Barrett's oesophagus relies on endoscopy, which is invasive and few who undergo the procedure are found to have condition. We aimed use machine learning techniques develop externally validate a simple risk prediction panel screen individuals oesophagus.MethodsIn this prospective study, in (MARK-BE), we used data from two case-control studies, BEST2 BOOST, compile training validation datasets. From analysed questionnaires 1299 patients, of whom 880 (67·7%) had...
ABSTRACT Introduction India has been under four phases of a national lockdown from March 25 to May 31 in response the COVID-19 pandemic. Unmasking state-wise variation effect nationwide on progression pandemic could inform dynamic policy interventions towards containment and mitigation. Methods Using data confirmed cases across 20 states that accounted for more than 99% cumulative case counts till 31, 2020, we illustrate masking state-level trends highlight variations by presenting...
Susceptible-Exposed-Infected-Removed (SEIR)-type epidemiologic models, modeling unascertained infections latently, can predict unreported cases and deaths assuming perfect testing. We apply a method we developed to account for the high false negative rates of diagnostic RT-PCR tests detecting an active SARS-CoV-2 infection in classic SEIR model. The number negatives being unobservable real study, population-based serosurveys help validate model projections. Applying our training data from...
ABSTRACT Underreporting of COVID-19 cases and deaths is a hindrance to correctly modeling monitoring the pandemic. This primarily due limited testing, lack reporting infrastructure large number asymptomatic infections. In addition, diagnostic tests (RT-PCR for detecting current infection) serological antibody IgG (to assess past infections) are imperfect. particular, have high false negative rate. Epidemiologic models with latent compartment unascertained infections like...
Endoscopic mucosal resection (EMR) is widely practiced in western countries. submucosal dissection (ESD) very effective for treating complex polyps but colonic ESD the setting remains challenging. We have developed a novel technique of knife-assisted snare (KAR) these lesions. Here we aim to describe technique, evaluate its outcomes, identify outcome predictors and define learning curve.We conducted prospective cohort study patients who had large refractory resected by KAR at our institution...
Personalized network inference on diverse clinical and in vitro model systems across cancer types can be used to delineate specific regulatory mechanisms, uncover drug targets pathways, develop individualized predictive models cancer.
Since March 25, 2020, India had been under a nation-wide lockdown announced as response to the spread of SARS-CoV-2 and COVID-19 has resorted process 'unlocking' over past couple months. This work attempts examine effect novel coronavirus 2019 (COVID-19) its resulting disease, COVID-19, on foreign exchange rates stock market performances using secondary data span 112 days spanning between 11 June 30, 2020. The study explores whether causal relationships directions among growth rate confirmed...
Objectives The EndoRings device is a distal attachment consisting of two layers circular flexible rings that evert mucosal folds. aim this study was to investigate whether EndoRing assisted colonoscopy ( ER ) improves polyp and adenoma detection compared standard SC ). Methods Multicenter, parallel group, randomized controlled trial. Results Total 556 patients n = 275) or 281). Colonoscopy completed in 532/556 (96%) cases. removed 74/275 (27%) patients. number polyps limb 582 vs. 515 limb, P...
Abstract Background Many popular disease transmission models have helped nations respond to the COVID-19 pandemic by informing decisions about planning, resource allocation, implementation of social distancing measures and other non-pharmaceutical interventions. We study how five epidemiological forecast assess course in India: a baseline model, an extended SIR (eSIR) two SEIR (SAPHIRE SEIR- fansy ) models, semi-mechanistic Bayesian hierarchical model (ICM). Methods Using data for India from...
<h3>Introduction</h3> Excess alcohol intake is associated with liver disease and pancreatic disease, however, the majority of individuals appear to present a single condition, for example, chronic disease. There paucity studies assessing prevalence in patients related (ALD). Detecting ALD may be important as symptoms go untreated nutrition affected. The aim this study was assess cohort ALD. <h3>Methods</h3> Consecutive seen outpatient clinic were invited participate. Demographics, severity...