A5080971020- Natural Compound Pharmacology Studies
- Natural product bioactivities and synthesis
- Phytochemistry and Biological Activities
- Bioactive Compounds and Antitumor Agents
- Insect Pest Control Strategies
- Essential Oils and Antimicrobial Activity
- Biological Activity of Diterpenoids and Biflavonoids
- Chromatography in Natural Products
- Phytochemistry Medicinal Plant Applications
- Phytochemical compounds biological activities
- Phytochemistry and biological activity of medicinal plants
- Bioactive Natural Diterpenoids Research
- Plant and animal studies
- Phytochemicals and Medicinal Plants
- Medicinal Plants and Neuroprotection
- Plant Parasitism and Resistance
- Phytochemistry and Bioactivity Studies
- Mosquito-borne diseases and control
- Ethnobotanical and Medicinal Plants Studies
- Venomous Animal Envenomation and Studies
- Traditional and Medicinal Uses of Annonaceae
- Plant biochemistry and biosynthesis
- Morinda citrifolia extract uses
- Marine Sponges and Natural Products
- Mitochondrial Function and Pathology
Fundação Oswaldo Cruz
2015-2024
Natura (Brazil)
2006-2024
National Institute of Science and Technology of Drugs and Medicines
2022
Universidade Federal Fluminense
1983-2019
Universidade Federal do Rio de Janeiro
1992-2012
Instituto de Tecnologia e Pesquisa
2007
Universidade Federal de Juiz de Fora
2006
Plumbagin is a naturally occurring naphthoquinone isolated from roots of Plumbago scandens. The plant was collected at the Campus Fundação Oswaldo Cruz, Rio de Janeiro, Brazil. P. scandens used as traditional medicine for treatment several diseases. antimicrobial activity plumbagin evaluated using macrodilution method. compound exhibited relatively specific against bacteria and yeast. minimum inhibitory concentration test showed growth inhibiton Staphylococcus aureus 1.56 g/ml Candida...
Carapa guianensis (Andiroba, Meliaceae) is considered a multipurpose tree. In Brazil, Indigenous people have used it as insect repellent and in the treatment of various diseases. Most biological activities popular uses are attributed to limonoids, which highly oxygenated tetranortriterpenoids. More than 300 limonoids been described Meliaceae family. Limonoids from Andiroba oil shown high anti-inflammatory anti-allergic vivo, by inhibiting platelet activating factors many inflammatory...
The Piper species are a recognized botanical source of broad structural diversity lignans and its derivatives. For the first time, tectoniifolium Kunth is presented as promising natural bioactive (-)-grandisin. Phytochemical analyses extracts from leaves, branches inflorescences showed presence target compound in large amounts, with leaf found to contain up 52.78% composition. A new HPLC-DAD-UV method was developed validated be selective for identification (-)-grandisin being sensitive,...
Abstract Introduction Limonoids are tetranortriterpenoids of considerable interest due to their structural varieties and biological activities, such as insecticidal, antibacterial, antifungal, antimalarial, anticancer antiviral. They contain oxygen atoms that confer a moderate polarity responsible for the difficulties in separation by traditional chromatographic methods. High‐speed countercurrent chromatography (HSCCC) is versatile liquid–liquid technique, which sample distributed between...
The Plumbago genus belongs to the Plumbaginaceae family and it is known due its variety of biological uses, most them attributed presence naphthoquinones. Plumbagin a naturally occurring naphthoquinone that can be obtained from roots scandens L. In order find out better technique for plumbagin extraction, were applied: static maceration, dynamic with assistance ultrasonic waves in Soxhlet apparatus. Four compounds qualitatively detected all extracts: naphthoquinones epi-isoshinanolone,...
Benzophenone derivatives are special metabolites that arouse great scientific interest. The Clusiaceae family is known for producing large amounts of benzophenone with several isoprene residues on their structures, which responsible the observed complexity and structural variety in this class substances, also contribute to biological activities. Clusia an important genus belonging Clusiaceae, 55 different polyisoprenylated benzophenones identified so far. These substances were analyzed from...
Abstract The antihypertensive action of a crude ethanolic extract (EEEG) from leaves Echinodorus grandiflorus (Alismataceae) was investigated in spontaneously hypertensive rats. intraperitoneal injection increasing doses EEEG (300–1000 mg/kg) elicited dose‐dependent reductions mean arterial pressure (MAP) that were paralleled by cardiac output and systemic vascular resistance, reaching the maximum 23 ± 5%, 13 3% 18 4%, respectively ( n = 5, P < 0.05). Comparable MAP obtained upon i.v....
The effects of the hexanic extracts fruits and flowers Clusia fluminensis Planch. & Triana, Clusiaceae, as well their main constituents, triterpene lanosterol benzophenone clusianone, were evaluated on hemipterans Dysdercus peruvianus Oncopeltus fasciatus. topical treatments insects with significantly affected survival O. fasciatus, but not that D. peruvianus. Concomitantly, delayed development both hemipterans. Moreover, isolated reduced fasciatus peruvianus, while clusianone only reduce...
Recently, the P2X(7) receptor has been reported to be associated with chronic inflammatory and neuropathic pain. Because Rheedia longifolia extract analgesic anti-inflammatory activity, we evaluated in vitro inhibitory potential of methanol fractions from its leaves on purinergic receptor. The activity was studied a dye uptake assay whole-cell patch clamp technique mouse peritoneal macrophages treated R. fractions. by flow cytometry fluorescence microscopy. some showed an effect...
PHYLOGENY OF Bignoniaceae.Our solemn homage to the great Master Otto R. Gottlieb who knew how teach mystery of evolutionary relationships between chemistry and its natural sources.The micromolecular chemical study family Bignoniaceae shows a profile predominantly characterized by occurrence metabolites derived from acetic acid biosynthetic pathways such as terpenoids, quinones, flavonoids special aromatic derivatives.Analysis different chemosystematic parameters for metabolite data...
Leishmaniasis is the generic denomination to neglected diseases caused by more than 20 species of protozoa belonging genus Leishmania. The toxic and parenteral-delivered pentavalent antimonials remain be first-line treatment. However, all current used drugs have restrictions. Aureliana fasciculata (Vell.) Sendtner var. a native Brazilian parsimoniously studied on chemical point view. In this study, antileishmanial activity A. was evaluated. Among evaluated samples leaves, dichloromethane...
Centrifugal liquid–liquid partition chromatography presents significant advantages for the separation and purification of plant metabolites owing to short operational time process elimination possible irreversible adsorption compounds. The crude chloroform extract from roots Plumbago auriculata was analysed by countercurrent using hexane:ethyl acetate:methanol:water (40:10:10:2, v/v) as solvent system. isolation naphthoquinones plumbagin epi-isoshinanolone, steroids sitosterol...
In Brazil, the Bothrops genus accounts for 87% of registered snakebites, which are characterized by hemorrhage, tissue necrosis, hemostatic disturbances, and death. The treatment recommended governments is administration specific antivenoms. Although antivenom efficiently prevents venom-induced lethality, it has limited efficacy in terms preventing local damage. Thus, researchers seeking alternative therapies able to inhibit main toxic effects venoms, without compromising safety.The study...
Severe dengue fever is a result of exacerbated immune responses and no specific treatments are available. We evaluated the antiviral immunomodulatory effects Norantea brasiliensis Choisy.Human adherent monocytes infected in vitro with virus (DENV)-2 were incubated crude ethanol extract from leaves (NB1) or 3 derived fractions: dichloromethane (NB3), ethyl acetate (NB5), butanolic (NB6) partitions. The activities determined by intracellular detection DENV antigen within secreted NS1 viral...