A5101952064- Ubiquitin and proteasome pathways
- Herpesvirus Infections and Treatments
- Cancer-related Molecular Pathways
- Cytomegalovirus and herpesvirus research
- Advanced Computing and Algorithms
- Surgical Sutures and Adhesives
- melanin and skin pigmentation
- Retinal Imaging and Analysis
- Healthcare and Venom Research
- Skin Protection and Aging
- Breast Cancer Treatment Studies
- Digestive system and related health
- Breast Lesions and Carcinomas
- Respiratory viral infections research
- RNA modifications and cancer
- Gastrointestinal motility and disorders
- Ideological and Political Education
- Virus-based gene therapy research
- Phytochemicals and Antioxidant Activities
- Plant and fungal interactions
- Digital Imaging for Blood Diseases
- Toxoplasma gondii Research Studies
- Immune Response and Inflammation
- DNA Repair Mechanisms
- Diet and metabolism studies
Tianjin University of Science and Technology
2024
Weifang People's Hospital
2024
Weifang Medical University
2024
Ocean University of China
2020-2024
Shandong University
2022
University at Buffalo, State University of New York
2021
Duke University
2021
Xinjiang University
2019
Louisiana State University Health Sciences Center Shreveport
2013
University of the Pacific
2011
Computer-aided diagnosis of retinopathy is a research hotspot in the field medical image classification. Diabetic macular edema (DME) and age-related degeneration (AMD) are two common ocular diseases that can result partial or complete loss vision. Optical coherence tomography imaging (OCT) widely applied to including DME AMD. In this paper, an automatic method based on deep learning proposed detect AME AMD lesions, which publicly available OCT datasets retina were adopted network model with...
We report a requirement for the viral protein kinase UL97 in human cytomegalovirus (HCMV) replication that maps to ULb' region of genome. A UL97-null (Δ97) mutant strain TB40/E, which encodes full-length region, exhibited defects, particularly production cell-free virus, were more severe than those seen with Δ97 laboratory AD169, harbors extensive deletions its region. These differences recapitulated additional HCMV strains by treatment inhibitor,...
Background The skin provides a predominant barrier against chemical, physical and microbial incursion. intemperate exposure to ultraviolet A (UVA) radiation can cause excessive cellular oxidative stress, leading damage, proteins damage mitochondrial dysfunction. There is sufficient evidences supporting the proposal that mitochondria highly implicated in photo-damage. Methods In present study, polysaccharide isolated from Astragalus membranaceus was further purified be an α-glucan, which...
Phyllodes tumors (PTs) has an increased risk of local relapse and distant metastases. Molecular features correlating to histologic grade aggressive behavior PTs are poorly characterized. Here, whole exome sequencing (WES) was performed explore genetic mutations in 61 samples fibroepithelial breast tumors, including 16 fibroadenomas (FAs), 18 benign PTs, 19 borderline 8 malignant PTs. Our work clearly shows that FA, PT, PT independent entities at the genomic level. They may exist as hidden...
ABSTRACT Human cytomegalovirus (HCMV) encodes one conventional protein kinase, UL97. During infection, UL97 phosphorylates the retinoblastoma tumor suppressor (pRb) on sites ordinarily phosphorylated by cyclin-dependent kinases (CDK), inactivating ability of pRb to repress host genes required for cell cycle progression S phase. is important viral DNA synthesis in quiescent cells, but this function can be replaced human papillomavirus type 16 E7, which targets degradation. However, viruses E7...
Functional intestinal imaging holds importance for the diagnosis and evaluation of treatment gastrointestinal diseases. Currently, preclinical motility in animal models is performed either invasively with excised intestines or noninvasively under anesthesia, cannot reveal dynamics awake condition. Capitalizing on near-infrared optics a high-absorbing contrast agent, we report Trans-illumination Intestine Projection (TIP) system free-moving mice. After complete evaluation, vivo studies,...
This article designs a nanny abnormal behavior recognition bracelet.The bracelet is equipped with multiple sensors and powerful control board, forming complete system, which realizes alarm in various environments.It uses gyroscope to collect the three-axis acceleration information of nanny, HAR model infer nanny's real-time behavior.When inferred, STM32 sends GPS collected positioning employer through ESP32 for timely alarm.
The aryl hydrocarbon receptor (AhR) is a ligand‐activated, basic helix‐loop‐helix‐PAS transcription factor which involves in xenobiotic metabolism and cell growth. Without ligand, the p23‐containing AhR complex present cytoplasm. Although roles of p23 for function were suggested, its necessity has been questioned. Our objective to investigate whether necessary Hepa1c1c7 cells. Using shRNA strategy, we generated p23‐knockdown stable (p23KD) cells contained 30% wild type content. When compared...
Abstract Background: Frequent developed resistance leads to early relapse and short survival in Triple-negative breast cancer (TNBC). Targeting DNA damage response (DDR) has become an effective strategy for overcoming TNBC chemoresistance. CENPF (centromere protein) is a key regulator of cell cycle progression, but its role chemotherapy remains unclear. Methods: We Used bioinformatics, immunohistochemical staining real-time quantitative PCR analysis explore the expression triple negative...
Abstract Background: Frequent developed resistance leads to early relapse and short survival in Triple-negative breast cancer (TNBC). Targeting DNA damage response (DDR) has become an effective strategy for overcoming TNBC chemoresistance. CENPF (centromere protein) is a key regulator of cell cycle progression, but its role chemotherapy remains unclear. Methods: We Used bioinformatics, immunohistochemical staining real-time quantitative PCR analysis explore the expression triple negative...