A5051212384- Regulation of Appetite and Obesity
- Adipokines, Inflammation, and Metabolic Diseases
- Hypothalamic control of reproductive hormones
- Pituitary Gland Disorders and Treatments
- Adrenal and Paraganglionic Tumors
- Adipose Tissue and Metabolism
- Biochemical Analysis and Sensing Techniques
- Glioma Diagnosis and Treatment
- Neurosurgical Procedures and Complications
- Chromatin Remodeling and Cancer
- Stability and Controllability of Differential Equations
- Cerebrospinal fluid and hydrocephalus
- Mathematical and Theoretical Epidemiology and Ecology Models
- Nonlinear Differential Equations Analysis
Universidade de São Paulo
2006-2024
Beth Israel Deaconess Medical Center
2014-2015
Harvard University
2015
Universidade Federal de São Carlos
2006
Leptin has beneficial effects on glucose metabolism via actions in the hypothalamus, but roles of specific subgroups neurons responsible for these antidiabetic remain unresolved. We generated diabetic Lep(ob/ob) or Lepr(db/db) mice lacking re-expressing leptin receptors (LepRb) to explore their contributions leptin's glucose-lowering actions. show that agouti-related peptide (AgRP)-expressing are both required and sufficient correct hyperglycemia by leptin. LepRb pro-opiomelanocortin (POMC)...
Hypothalamic agouti-related peptide (AgRP) and pro-opiomelanocortin (POMC) expressing neurons play critical roles in control of energy balance. Glutamatergic input via n-methyl-d-aspartate receptors (NMDARs) is pivotal for regulation neuronal activity required AgRP normal body weight homeostasis. NMDARs typically consist the obligatory GluN1 subunit different GluN2 subunits, latter exerting crucial differential effects on channel function. Currently, role specific subunits POMC whole glucose...
Summary Postoperative (PO) complications after transsphenoidal surgery (TSS) are rare when performed in pituitary referral centers. Partial hypopituitarism is more frequent and somewhat expected. Meningitis, cerebrospinal fluid leaks, visual deficits unusual. Cerebrovascular complications, including cerebral vasospasm rare, usually under-appreciated not mentioned to the patient prior surgery. This a report of 51-year-old male with non-functioning macroadenoma presenting partial field loss....
Leptin plays an important role in the protection against diet-induced obesity (DIO) by its actions ventromedial hypothalamic (VMH) neurons. However, little is known about intracellular mechanisms involved these effects. To assess of STAT3 and ERK2 signaling neurons that express steroidogenic factor 1 (SF1) VMH energy homeostasis, we used cre-lox technology to generate male female mice with specific disruption or SF1 VMH. We demonstrated conditional knockout did not affect body weight, food...
Studies addressing the methylation pattern in adamantinomatous craniopharyngioma (ACP) are lacking.
Leptin plays an important role in the protection against diet-induced obesity (DIO) by its actions ventromedial hypothalamic (VMH) neurons. However, little is known about intracellular mechanisms involved these effects. To assess of STAT3 and ERK2 signaling neurons that express steroidogenic factor 1 (SF1) VMH on energy homeostasis, we used cre-lox technology to generate male female mice with specific disruption or SF1 VMH. We demonstrated conditional knockout did not affect body weight,...
Leptin plays an important role in the protection against diet-induced obesity (DIO) by its actions ventromedial hypothalamic (VMH) neurons. However, little is known about intracellular mechanisms involved these effects. To assess of STAT3 and ERK2 signaling neurons that express steroidogenic factor 1 (SF1) VMH on energy homeostasis, we used cre-lox technology to generate male female mice with specific disruption or SF1 VMH. We demonstrated conditional knockout did not affect body weight,...