A5069184240- Regulation of Appetite and Obesity
- Adipose Tissue and Metabolism
- Biochemical Analysis and Sensing Techniques
- Animal Nutrition and Physiology
- Adipokines, Inflammation, and Metabolic Diseases
- Metabolism, Diabetes, and Cancer
- Aquaculture Nutrition and Growth
- Clusterin in disease pathology
- Neurological Disorders and Treatments
- Pain Mechanisms and Treatments
- Meat and Animal Product Quality
- Reproductive Physiology in Livestock
- Livestock and Poultry Management
- Neurobiology and Insect Physiology Research
- Eicosanoids and Hypertension Pharmacology
- Inflammatory mediators and NSAID effects
- Transcranial Magnetic Stimulation Studies
- Heart Rate Variability and Autonomic Control
- Veterinary Equine Medical Research
- Lipid metabolism and disorders
- Veterinary Orthopedics and Neurology
- Dietary Effects on Health
- Cancer, Stress, Anesthesia, and Immune Response
- Rabbits: Nutrition, Reproduction, Health
- Animal health and immunology
Beth Israel Deaconess Medical Center
2015-2024
Harvard University
2015-2024
Adnan Menderes University
2004-2024
The University of Texas Southwestern Medical Center
2024
Hadassah Medical Center
2022
A study was carried out to evaluate the effect of dietary probiotic supplementation and stocking density on performance, relative carcass yield, gut microflora, stress markers broilers. One-day-old Ross 308 male broiler chickens (n = 480) were allocated 4 experimental groups for 42 d. Each treatment had 8 replicates 15 chicks each. Two subjected a high (HSD) 20 birds/m2 other 2 kept at low (LSD) 10 birds/m2. basal diet supplemented with 1 0.5 g/kg (in starter finisher diets, respectively)...
Abstract Leptin regulates both feeding and glycaemia primarily through its receptors expressed on agouti-related peptide (AgRP) pro-opiomelanocortin-expressing (POMC) neurons; however, it is unknown whether activity of these neuronal populations mediates the regulation processes. To determine this, we injected Cre-dependent designer exclusively activated by drugs (DREADD) viruses into hypothalamus normoglycaemic diabetic AgRP-ires-cre POMC-cre mice to chemogenetically activate or inhibit...
Abstract Crosstalk between liver and skeletal muscle is vital for glucose homeostasis. Hepatokines, liver-derived proteins that play an important role in regulating metabolism, are to this communication. Here we identify apolipoprotein J (ApoJ) as a novel hepatokine targeting metabolism insulin sensitivity through low-density lipoprotein receptor-related protein-2 (LRP2)-dependent mechanism, coupled with the receptor (IR) signaling cascade. In muscle, LRP2 necessary insulin-dependent IR...
Abstract AgRP neurons in the arcuate nucleus of hypothalamus (ARC) coordinate homeostatic changes appetite associated with fluctuations food availability and leptin signaling. Identifying relevant transcriptional regulatory pathways these has been a priority, yet such attempts have stymied due to their low abundance rich cellular diversity ARC. Here we generated neuron-specific transcriptomic chromatin accessibility profiles from male mice during three distinct hunger states satiety,...
A trial was conducted to investigate the effects of a dietary organic acid blend for period 35 days on growth performance, intestinal histomorphology and microflora male broiler chicks with delayed access feed. One hundred ninety two one day old (ROSS 308) were randomly distributed into 4 groups housed in four replicate pens 12 birds each. 2 × factorial design implemented. Four experimental formed by levels supplementation (Control Fysal Dry®) periods feed (0 36 h). At h after hatching body...
Low-density lipoprotein receptor-related protein-1 (LRP1) regulates energy homeostasis, blood-brain barrier integrity, and metabolic signaling in the brain. Deficiency of LRP1 inhibitory gamma-aminobutyric acid (GABA)ergic neurons causes severe obesity mice. However, impact on memory function cognition context is poorly understood. Mice lacking GABAergic (Vgat-Cre; LRP1loxP/loxP) underwent behavioral tests for locomotor activity motor coordination, short/long-term spatial memory, fear...
A five‐year‐old female dog was presented with a four‐week history of inappetence, weight loss, and skin gait abnormalities. Physical examination revealed weakness, depression, incoordination the posterior limbs, emaciation, hair coat alterations, peripheral lymphadenopathy, pale mucous membranes fever. Laboratory analysis samples abnormalities which included anaemia, neutrophilic leucocytosis, thrombocytopenia, low serum glucose albumin concentrations, increased alkaline phosphatase...
Hypothalamic agouti-related peptide (AgRP) and pro-opiomelanocortin (POMC) expressing neurons play critical roles in control of energy balance. Glutamatergic input via n-methyl-d-aspartate receptors (NMDARs) is pivotal for regulation neuronal activity required AgRP normal body weight homeostasis. NMDARs typically consist the obligatory GluN1 subunit different GluN2 subunits, latter exerting crucial differential effects on channel function. Currently, role specific subunits POMC whole glucose...
[Purpose] The current study aimed to reveal the therapeutic effects of a pulsed electromagnetic field and swimming exercises on rats with experimental sciatic nerve injury, which was induced crush-type neuropathy model damage, using electrophysiological methods. [Subjects] In study, sample consisted 28 adult male Wistar albino rats. [Methods] were randomized into four groups (n=7). Swimming exercise PEMF (2 Hz 0.3 MT) applied one hour day, five days week, for weeks. Electroneuromyographic...
Low-density lipoprotein receptor-related protein 1 (LRP1) is a member of LDL receptor family that plays key role in systemic glucose and lipid homeostasis. LRP1 also regulates energy balance the hypothalamus by mediating leptin's anorexigenic action, although underlying neurocircuitry involved still unclear. Because GABAergic neurons are major mediator hypothalamic leptin we studied action using mice lacking Vgat- or AgRP-expressing (Vgat-Cre;
Introduction/Aim: Regular exercise may have beneficial effects on high blood-pressure, as shown in different types of experimental hypertension models rats. The present study aims to investigate the 6-week swimming training blood pressure, oxidative stress variables selected tissues, serum adrenomedullin (ADM) levels, and situ muscle contraction rats with induced by Nω-nitro-L-arginine methyl ester hydrochloride (L-NAME), an inhibitor endothelial nitric oxide synthases (eNOs).Materials...
The study is aimed to determine the beneficial effects of methyl palmitate (MP) which has antioxidant and anti-inflammatory demonstrated on murine model acute lung injury induced by lipopolysaccharide (LPS).Forty male BALB/C mice were randomly allocated into four groups (n=10, each): control group, group (300 mg/kg), LPS -treated groups. Methyl or vehicle was given with an intraperitoneal administration 1 h before intratracheal instillation (5 mg/kg). severity pulmonary evaluated 6 after...
The aim of this study was to investigate the H-reflex in forelimb and compare hindlimb results Hmax/Mmax ratios rabbit. For purpose, we used 15 healthy adult female New Zealand albino rabbits. Left limbs rabbits were for stimulation recording procedures using general anesthesia. Electrophysiological tests performed Nikolet Viking Quest (USA) 2-channel EMG equipment. median tibial nerves evaluate M-waves. Latencies almost same both limbs. However, M-wave latencies amplitudes significantly...
Moderate exercise stimulates immune system whereas intensive may display immune-suppressive effect associated with the disruption of intestinal barrier. With this study, we tested effects moderate and swimming exercises on some cytokines oxidant variables zonulin, an barrier marker, in rats. We also possible ameliorative probiotic VSL#3 both regimens. Twenty eight rats were randomly divided into 4 equal groups: Control-C, Probiotic-P, Exercise-E, Probiotic+Exercise-PE. The group E PE...
Adipocyte-derived leptin enters the brain to exert its anorexigenic action, yet transport mechanism is poorly understood. Here we report that LRP1 (low-density lipoprotein receptor-related protein-1) mediates of across blood-CSF barrier in Foxj1 expressing cells highly enriched at choroid plexus (ChP), coupled with short-form receptor, and deletion from ependymocytes ChP leads resistance hyperphagia, causing obesity. Thus, epithelial a principal regulator brain.
ABSTRACT Objective Low-density lipoprotein receptor-related protein-1 (LRP1) regulates energy homeostasis, blood-brain barrier integrity, and metabolic signaling in the brain. Loss of LRP1 from inhibitory gamma-aminobutyric acid (GABA)ergic neurons causes severe obesity mice. Its dysfunction has been associated with cognitive decline, dementia, Alzheimer’s disease. However, impact on memory function cognition context is poorly understood. Methods Mice lacking GABAergic ( Vgat-Cre; loxP/loxP...
: Classical risk factors such as cholesterol and lipoproteins are currently not sufficient to explain all physiopathological processes of obesity-related vascular dysfunction well atherosclerosis arteriosclerosis. Therefore, the discovery potential markers involved in obese state is still needed. Disturbances hemostatic may be developmental associated with cardiovascular disorders. We hypothesized that alterations several could correlate function morphology aorta it play an important role...