A5081891227- Air Quality and Health Impacts
- Adipose Tissue and Metabolism
- Climate Change and Health Impacts
- Dietary Effects on Health
- Birth, Development, and Health
- Antioxidant Activity and Oxidative Stress
- Neuroinflammation and Neurodegeneration Mechanisms
- Gut microbiota and health
- Regulation of Appetite and Obesity
- Noise Effects and Management
- Nutritional Studies and Diet
- Biochemical effects in animals
Universidade Estadual de Campinas (UNICAMP)
2018-2024
Beth Israel Deaconess Medical Center
2024
Harvard University
2024
Abstract A previous study demonstrated that a high-fat diet (HFD), administered for one-three-days, induces hypothalamic inflammation before obesity’s established, and the long term affects leptin signaling/action due to inflammation. We investigate whether exposure particulate matter of diameter ≤2.5 μm (PM 2.5 ) in mice fed with chow leads similar metabolic effects caused by feeding. Compared filtered air group (FA), one-day-exposure-PM did not affect adiposity. However,...
Introduction The timing of maternal exposure to air pollution is crucial define metabolic changes in the offspring. Here we aimed determine most critical period particulate matter (PM 2.5 ) that impairs offspring's energy metabolism and gut microbiota composition. Methods Unexposed female male C57BL/6J mice were mated. PM or filtered (FA) occurred only gestation /FA) lactation (FA/PM ). We studied offspring both genders. Results during increased body weight (BW) at birth from weaning young...
Low-density lipoprotein receptor-related protein-1 (LRP1) regulates energy homeostasis, blood-brain barrier integrity, and metabolic signaling in the brain. Deficiency of LRP1 inhibitory gamma-aminobutyric acid (GABA)ergic neurons causes severe obesity mice. However, impact on memory function cognition context is poorly understood. Mice lacking GABAergic (Vgat-Cre; LRP1loxP/loxP) underwent behavioral tests for locomotor activity motor coordination, short/long-term spatial memory, fear...
Low-density lipoprotein receptor-related protein-1 (LRP1) regulates energy homeostasis, and its dysfunction has been linked to cognitive decline, dementia, Alzheimer’s disease. However, the impact of LRP1 in inhibitory neurons on memory function cognition obesity remains unexplored. Mice lacking GABAergic (Vgat-Cre; LRP1loxP/loxP) are subjected conduct behavioral tests locomotor activity motor coordination, short/long-term spatial memory, fear learning/memory. We evaluated relationships...
Air pollution affects energy homeostasis detrimentally. Yet, knowledge of how each isolated pollutant can impact metabolism remains incomplete. The present study was designed to investigate the distinct effects 1,2-naphthoquinone (1,2-NQ) on since this increases at same rate as diesel combustion. In particular, we aimed determine in vivo subchronic exposure 1,2-NQ metabolic and inflammatory parameters wild-type mice (WT) explore involvement tumor necrosis factor receptor 1 (TNFR1) toll-like...
Air pollution is involved in several processes harmful to health. PM2,5 the most associated with induction of chronic inflammation. Hypothalamus regulates energy homeostasis thought metabolic, neural and hormonal signals. Leptin signaling participates this process, hypothalamic inflammation may induce leptin resistance. TLR4 an innate immune receptor capable triggering subclinical inflammation, one its agonists LPS, which known be present PM2.5 composition. Polluted C57 mice had increased...
Fine particulate matter (PM2.5) is the most harmful component of air pollution and associated with an increased risk cardiometabolic diseases, such as T2DM. The small diameter PM2.5 allows it to be inhaled subsequently invades tissues through airways. Intake also possible even if this not primary route entry into body. However, still unclear whether ingestion inhalation in a short time would sufficient alter gut microbiota energy metabolism. Thus, we aimed investigate 1 day or 5 days...