A5070270065- Air Quality and Health Impacts
- Climate Change and Health Impacts
- Prenatal Substance Exposure Effects
- Birth, Development, and Health
- Cannabis and Cannabinoid Research
- Energy and Environment Impacts
- Nutrition, Genetics, and Disease
- Noise Effects and Management
- Sexual Differentiation and Disorders
- Neonatal and fetal brain pathology
- Neonatal Health and Biochemistry
- Reproductive Biology and Fertility
- Systemic Lupus Erythematosus Research
- Oral Health Pathology and Treatment
- Peroxisome Proliferator-Activated Receptors
- Animal Genetics and Reproduction
- Immune Cell Function and Interaction
- Sperm and Testicular Function
- Per- and polyfluoroalkyl substances research
- Animal Disease Management and Epidemiology
- Immune cells in cancer
- Chemokine receptors and signaling
- Diabetes Treatment and Management
- Cancer, Lipids, and Metabolism
- Renal Diseases and Glomerulopathies
Universidade de São Paulo
2017-2024
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
2019-2024
Universidade Federal do ABC
2023-2024
Universidade Nove de Julho
2020
Air pollution is a public health concern that has been associated with adverse effects on the development and functions of central nervous system (CNS). However, studies exposure to pollutants CNS across entire developmental period still remain scarce. In this study, we investigated impacts prenatal and/or postnatal fine particulate matter (PM2.5) from São Paulo city, brain structure behavior juvenile male mice. BALB/c mice were exposed PM2.5 concentrated ambient particles (CAP) at daily...
Introduction The timing of maternal exposure to air pollution is crucial define metabolic changes in the offspring. Here we aimed determine most critical period particulate matter (PM 2.5 ) that impairs offspring's energy metabolism and gut microbiota composition. Methods Unexposed female male C57BL/6J mice were mated. PM or filtered (FA) occurred only gestation /FA) lactation (FA/PM ). We studied offspring both genders. Results during increased body weight (BW) at birth from weaning young...
Air pollution causes negative impacts on health. Systemic lupus erythematosus (SLE) is an autoimmune disease with diverse clinical manifestations and multifactorial etiology. Recent studies suggest that air can trigger SLE induce activity. However, this association has not been deeply investigated. Thus, the aim of study was to evaluate whether exposure fine particulate matter (PM2.5) exacerbates manifestations, focusing renal complications, in a lupus-prone animal model. Female NZBWF1 mice...
Abstract Epidemiological and toxicological studies have shown that inhalation of particulate matter (PM) is associated with development cardiovascular diseases. Long‐term exposure to PM may increase the risk events reduce life expectancy. Systemic lupus erythematosus (SLE) a chronic inflammatory disease, autoimmune in nature, characterized by production autoantibodies affects several organs, including heart. Air pollution ‐ which can be caused different factors one most important points both...
The aim of this study was to characterize the parameters reproductive anatomy and pituitary hormone expression levels in ames dwarf mice (Prop1 df/df). Male Prop1df/df aged 30 days received daily intraperitoneal injections recombinant human GH levothyroxine three times weekly for 60 days. sexual maturation these animals compared with that their wild-type (Prop +/+) untreated (Prop1df/df ) siblings. treated group developed 2 weeks later than Prop +/+ presented an increase testicular weight,...
Abstract Background Prenatal exposure to Cannabis is a worldwide growing problem. Although retina part of the central nervous system, impact maternal use on retinal development and its postnatal consequences remains unknown. As prenatal period potentially sensitive in normal retina, we hypothesized that recreational during pregnancy may alter structure offspring. To test this, developed murine model mimics human terms dose use. Methods Pregnant BalbC mice were exposed daily for 5 min smoke...
The risk of dementia and Alzheimer's disease in Latin America the Caribbean (LAC) rises with increasing age polluted air. Currently, at least 172 million people breathe unhealthy levels air pollution LAC countries. Several cohort studies have indicated that increases developing neurodegenerative diseases, but mechanisms underlying association are still not clear. Air causes aggravates five established factors for (obesity, hypertension, stroke, diabetes mellitus, heart diseases) is linked to...
Atmospheric pollution can be defined as a set of changes that occur in the composition air, making it unsuitable and/or harmful and thereby generating adverse effects on human health. The regular practice physical exercise (PE) is associated with preservation improvement health; however, influenced by neuroimmunoendocrine mechanisms external factors such air pollution, highlighting need for studies involving PE polluted environments. Herein, 24 male C57BL/6 mice were evaluated, distributed...
Abstract Disclosure: B.V. Azevedo: None. N. Trigueiro: J.M. Marques: V. Yariwake: L. Tamashiro: R. Cruz: M.M. Veras: Carvalho: Introduction: The Ames lineage, a mouse model with mutation in the Prop1 gene, exhibits GH, TSH, and PRL deficiencies along low levels of gonadotropins. This has prompted an investigation into aging reproductive restoration after hormone replacement reported literature. Aims: present study aims to analyze pathophysiologic mechanisms system fertility restoration....
Abstract Disclosure: B.V. Azevedo: None. N. Trigueiro: J.M. Marques: V. Yariwake: L. Tamashiro: R. Cruz: M.M. Veras: Carvalho: Introduction: The Ames lineage, a mouse model with mutation in the Prop1 gene, exhibits GH, TSH, and PRL deficiencies along low levels of gonadotropins. This has prompted an investigation into aging reproductive restoration after hormone replacement reported literature. Aims: present study aims to analyze pathophysiologic mechanisms system fertility restoration....
Abstract Epidemiological and toxicological studies have shown that inhalation of particulate matter (PM) is associated with development cardiovascular diseases. Long-term exposure to PM may increase the risk events reduce life expectancy. Systemic lupus erythematosus (SLE) a chronic inflammatory disease autoimmune nature, characterized by production autoantibodies affects several organs, including heart. Caused factors, air pollution, appear as one most important points on onset SLE. This...
ABSTRACT Air pollution is comprised of several substances, including particulate matter (PM). Exposure to air may trigger alterations in DNA methylation thus modifying gene expression patterns. This phenomenon likely mediate the relationship between exposure and adverse health effects. The purpose this study was analyzing effects PM 2.5 during pregnancy or lactation whether it would cause multigenerational epigenetic promoter region genes Pdx1 NEUROG3 within mouse pancreatic islets. Our...