Abstract Adenomatous polyposis coli ( APC ) mutations are the most frequently identified genetic alteration in sporadic colorectal cancer (CRC) cases, and a myriad of genetically engineered Apc ‐mutant CRC mouse models have been developed using various manipulation techniques. The advent CRISPR/Cas9 system has revolutionized field engineering facilitated development new models. In this study, we aimed to develop novel knockout allele evaluate phenotypic effects two different strains. For...

This study was conducted to the effects of dietary garlic powder on laying performance, egg traits and blood serum cholesterol level quails.A total three hundred quails (Coturnix coturnix japonica) aged nine weeks were used.They allocated 3 treatments.Each treatment comprised 5 replicates 20 quails.The diets supplemented with 0, 10 g/kg powder.The experimental period lasted 21 weeks.The addition did not significantly affect body weight, production, feed consumption, efficiency, shell...

The aim of the present study was to investigate usage thyme leaves and its effects on performance, some egg quality traits humoral immunity in laying hens. A total 108 hens aged 36 weeks were randomly assigned three dietary groups for 16 weeks. Dried ground (Thymus vulgaris L.) used at level 0, 1 2% diets groups. Feed intake, body weight, production, weight characteristics not affected by supplementation. Thyme supplementation resulted beneficial due lowering yolk cholesterol saturated fatty...

This experiment was carried out to determine the effects of supplementation L-carnitine and humic substances alone or in combination laying hen diets on performance, egg traits blood parameters.A total 180 IGH type brown hens aged 22 weeks were employed a completely randomized block design with one control group three treatment groups.Each divided into five replicates as subgroups, each comprising 9 hens.The first, second third groups supplemented 0.1 g/kg L-carnitine, 1.5 (Farmagülator ®...

ABSTRACT Neuroinflammation can be triggered by a high‐fat/high‐fructose diet (HFFD), and CD36 may an underlying mechanism. Lauric acid (LA), the major fatty in coconut oil, resveratrol, plant‐based polyphenolic compound, exert anti‐inflammatory effects. Therefore, this study investigated possible effects of LA resveratrol on diet‐induced neuroinflammation CD36. Healthy male C57BL/6 mice (8 weeks age, n = 31) were fed control (10%kcal fat) or diets containing high fat (60%kcal fructose (5%...

This experiment was carried out to determine the effects of usage dried brewing yeast in quail diets on laying performance, egg traits and blood parameters. A total 240 Japanese quails (Coturnix coturnix japonica) aged 10 weeks were randomly allocated into one control group three treatment groups. Each divided five replicates as subgroups, comprising 12 each. Dried (Saccharomyces cerevisiae) used at levels 1.5%, 3.0% 4.5% first, second third groups, respectively. Soyabean meal replaced with...

Several studies have indicated the influence of a maternal low protein diet on fetus. However, effect quality fetal growth and development is largely unknown. Wistar rats (11 weeks old) were mated maintained either chow with 20% casein (n = 6) as control group (C), or wheat gluten 7) experimental (WG) through gestation lactation. Maternal body weights similar in both groups throughout study. Birth not influenced by offspring during lactation between groups. Offspring’s plasma amino acid...

The pathological endpoint of congenital and senile myopathies is chronic muscle degeneration characterized by the atrophy contractile elements, accompanied fibrosis fatty infiltration interstitium. Tenotomy release preload that causes abrupt shortening models without prominent inflammatory response. Fibrosis in skeletal known to be triggered transforming growth factor (TGF)-β, which activated events. As these were lacking, tenotomy provided an opportunity investigate transcriptional events...

The increase in poultry production and the high cost of soybean led to search for alternative protein sources. One these sources is vinasse, a by-product baker's yeast industry. Modified dried vinasse (MDV) can be produced use nutrition by making some improvements vinasse. Therefore, present study aimed examine effect usage MDV broiler diets. A total 192 daily male Ross 308 chicks were randomly assigned four groups. was included at levels 0%, 2%, 4%, 6% diets 42-day trial. Linear significant...

Abstract Nutrition during pregnancy and lactation is a critical factor in the development of offspring. Both protein content source maternal diet affect neonatal health, but long-term effects low-quality on offspring are less clear. This study aimed to examine offspring’s growth, development, circulating metabolites hepatic expression methyltransferases. Virgin Wistar rats were mated at 11 weeks age. Dams then maintained either chow with 20% casein as control group (C), or wheat gluten...

Acetaminophen (AAP) is a commonly used analgesic and antipyretic drug; however, when in high doses, it causes fulminant hepatic necrosis both humans experimental animals. In this study, we investigated whether selenium (Se) N-acetylcysteine (NAC), alone or combination, are protective against AAP toxicity mice. At the beginning of experiment, blood samples were taken from 10 350 Then, remaining mice randomly allocated into four groups, each consisting 35 The 1st group received single...

Brain-derived neurotrophic factor (BDNF) is a growth of the neurotrophin family. Recent studies indicate that its expression regulated by Wnt/β-catenin signaling. In this study, we aimed to examine effects reduced Bdnf levels in an Apc mutant intestinal/colonic tumor mouse model.We crossed Apc+/- and Bdnf+/- C57BL/6 mice. After genotyping litters, Apc+/+ Bdnf+/+ (wild-type, wt), (Apc mutant), (Bdnf (Apc/Bdnf double mutant) mice cohorts were generated. All followed daily for 36 weeks weighed...

Objective: To compare fetal cell microchimerism in normal and immunocompromised gestations. Materials methods: The study consists of two groups mature female mice. In the control group group, 5 mg saline cyclosporine were injected intraperitoneally, respectively. second step, all mice mated with "Actine-Luc (+) green fluorescent protein (GFP)" transgenic male Immunohistochemical studies (ALPL-antiluciferase, cytokeratin-antiluciferase, CD 105-antiluciferase) carried out on maternal liver,...

Algae, which are used as supplementary nutrients in various countries, products rich protein, vitamins and minerals. The aim of this study was to investigate the effects algae extracts on healing colonic anastomosis malnourished rats.Seventy-two rats were randomized three groups. Group 1 fed with standard diet for 15 days, before after anastomosis. Groups 2 3 a malnutrition days prior then basic there after. also received an extract derived from Cholerella sp. via oral gavage...

In the district of Anatolia, located in South Eastern Turkey, an aqueous extract roots Astragalus is traditionally used against leukemia and for its wound-healing properties. Known biologically active constituents represent two major classes chemical compounds, polysaccharides saponins [1].

This study aimed to investigate the immunogenicity of hepatitis B virus (HBV) vaccine by applying a normal and high-dose vaccination program in mice modeling non-alcoholic fatty liver disease (NAFLD). NAFLD was induced mouse livers via diet. At 10-week mark, both groups were divided into 3 subgroups. While standard dose applied on days 0, 7, 21, two programs applied: one 0 other 21. All euthanized. Blood samples from anti-HB titers; T follicular helper, regulatory, CD27

As part of our continuing search for wound healing from medicinal sources, we analysed Spirulina platensis crude extract (cyanobacteria) and c-phycocyanin. The blue-green microalgae spirulina a non-nitrogen fixing, consumed in daily diets natives Africa America, has been found to be rich natural source proteins, carotenoids other micronutrients [1]. Recent studies have demonstrated antioxidant, antimutagenic, antiviral, anticancer, anti-allergic, immune enhancing, hepato-protective, blood...

Bu araştırmanın amacı, endüstri koşulları altında yumurta tavuğu yemlerinde sepiyolit kullanımının pelet kalitesine ve üretim parametrelerine olan etkisini belirlemektir. Araştırmada, kontrol deneme grubu için yedişer parti olmak üzere her grup toplam 14 tonluk yem ticari bir fabrikasında üretilmiştir. Her 2 tondur. Üretilen yemi %14,12 ham protein, %4,47 selüloz %3,20 yağ içermektedir. Deneme yemine karıştırıcıda %1 ilave edilmiştir (top-dressed). Fabrikada 6 mm delik çaplı peletleme diski...

Clinical diagnosis of diphtheria is often difficult, in particular countries where the disease rarely observed, such as Turkey. In 2011, after 12 years no recorded cases Turkey, a 34-year-old woman was diagnosed with diphtheria; she later died myocarditis. this study, we aimed to demonstrate diagnostic potential an immunofluorescent antibody method determine presence toxin (DT) myocardial cells DT-injected rabbits and female subject.