A5041701612- Neuroscience and Neuropharmacology Research
- Autism Spectrum Disorder Research
- Nerve injury and regeneration
- Epilepsy research and treatment
- Ion channel regulation and function
- Chemotherapy-induced organ toxicity mitigation
- Genetics and Neurodevelopmental Disorders
- Adenosine and Purinergic Signaling
- Cancer, Hypoxia, and Metabolism
- Cancer Treatment and Pharmacology
- Parkinson's Disease Mechanisms and Treatments
- Pharmacological Effects and Toxicity Studies
- Cancer, Lipids, and Metabolism
- Microtubule and mitosis dynamics
- Neuropeptides and Animal Physiology
- Cancer Research and Treatments
- Neuroendocrine regulation and behavior
- Neuroinflammation and Neurodegeneration Mechanisms
- Pancreatic and Hepatic Oncology Research
- Sirtuins and Resveratrol in Medicine
- Neuroblastoma Research and Treatments
- Liver Disease Diagnosis and Treatment
- Chemotherapy-induced cardiotoxicity and mitigation
- Curcumin's Biomedical Applications
- Nicotinic Acetylcholine Receptors Study
Izmir Kâtip Çelebi University
2018-2025
Istanbul Bilim University
2020-2023
Istanbul University
2023
Izmir Atatürk Eğitim ve Araştırma Hastanesi
2023
Bezmiâlem Vakıf Üniversitesi
2023
National Dong Hwa University
2022
Bridge University
2022
E-Da Hospital
2022
Ain Shams University
2022
National Sun Yat-sen University
2022
Worldwide, over 10 million individuals suffer from drug-resistant epilepsy. New therapeutic strategies are needed to address this debilitating disease. Inhibition of sodium-glucose linked transporters (SGLTs), which variably expressed in the brain, has been demonstrated reduce seizure activity murine models Here we investigated effects dapagliflozin, a highly competitive SGLT2 inhibitor currently used as drug for diabetes mellitus, on rats with pentylenetetrazol (PTZ) induced seizures....
Abstract The aim of the present study was to compare effects artificial sweeteners (aspartame, saccharin, and sucralose) on rat brain. Twenty‐four adult male Sprague–Dawley rats were included in study. control group ( n = 6) received regular tap water, whereas other groups aspartame (3 mg/kg/day, 6,) or saccharin sucralose (1.5 drinking water. Following 6 weeks, passive avoidance learning (PAL) test performed evaluate neurobehavioral sweeteners. brains assessed for lipid peroxides, neuron...
Diabetic neuropathy (DN) is a heterogeneous condition characterized by complex pathophysiological changes affecting both autonomic and somatic components of the nervous system. Inflammation oxidative stress are recognized contributors to pathogenesis DN. This study aims evaluate therapeutic potential dichloroacetic acid (DCA) in alleviating DN symptoms, focusing on its anti-inflammatory antioxidant properties. Thirty-two adult male Sprague Dawley rats were divided into four groups: Control,...
Abstract Background Previous studies have indicated an association between maternal metabolic conditions and general developmental disturbances of the offspring. Objective We aimed to investigate influence long‐term fructose intake during gestation lactation on neurobehavioral development rat Methods Twelve female Sprague Dawley rats were received either 30% enriched water (n = 6) or regular tap (control, n for 12 weeks. Then, control fructose‐received females caged with a fertile male, chow...
Abstract The COVID-19 pandemic catalyzed the swift development and distribution of mRNA vaccines, including BNT162b2, to address disease. Concerns have arisen about potential neurodevelopmental implications these especially in susceptible groups such as pregnant women their offspring. This study aimed investigate gene expression WNT, brain-derived neurotrophic factor (BDNF) levels, specific cytokines, m-TOR expression, neuropathology, autism-related neurobehavioral outcomes a rat model....
Systemic but not topical tacrolimus (TAC) is effective against psoriasis. Mechanical methods that enhance skin penetration by TAC increase its antipsoriatic effect. Liposomal delivery of would skin, allow for slow release and diminish toxicity.To test a liposomal (LTAC) formulation in murine model.Drug was assessed using radiolabelled LTAC, the effect LTAC on Balb/c graft survival ovalbumin-induced delayed-type hypersensitivity reactions tested C57BL/6 mice.Radiotracer studies showed...
Polycystic ovary syndrome is a of ovarian dysfunction. Oxidative stress, inflammation and endothelial cell activation are thought to play concomitant roles in the pathogenesis above diseases particularly development atherosclerotic lesions.We studied 58 polycystic patients age-matched 25 healthy controls consisting women that have regular, ovulatory cycles normal androgen levels. Homeostasis Model Assessment-Insulin Resistance for this study was taken as 1.75 upper level confidence interval...
Pancreatic stellate cells (PSC) have been recognized as the principal responsible for production of fibrosis in pancreatic ductal adenocarcinoma (PDAC). Recently, PSCs noted to share characteristics with monocyte-macrophage lineage (MML cells). Thus, we tested whether could be targeted nitrogen-containing bisphosphonates (NBP; pamidronate or zoledronic acid), which are potent MML cell inhibitors. In addition, NBPs treatment combination nanoparticle albumin-bound paclitaxel (nab-paclitaxel)...
A series of tacrine-donepezil hybrids were synthesized as potential multifunctional anti-Alzheimer's disease (AD) compounds. For this purpose, tacrine and the benzylpiperidine moiety donepezil fused with a hydrazone group to achieve small library hybrids. In agreement design, all compounds showed inhibitory activity toward both acetylcholinesterase (AChE) butyrylcholinesterase (BChE) IC
Abstract Previous studies have established anti‐inflammatory, antioxidant, and neuroprotective effects of Exenatide in the central nervous system. Since these mechanisms are thought to important roles pathophysiology autism, we hypothesized that may healing autism. We tested this hypothesis by examining an experimental autism model created lipopolysaccharide (LPS) exposure womb, with behavioral tests, histopathological examinations, biochemical measurements. The was administration LPS (i.p)...
Peripheral nerve damage is a significant clinical problem with limited therapeutic options. Adipose-derived mesenchymal stem cells (ADSCs) have emerged as promising approach due to their regenerative potential. However, the underlying mechanisms by which ADSCs promote peripheral regeneration remain unclear. In this study, we investigated role of syndecan-1 and heat shock protein 70 (HSP-70) in mediating effects on nerves. were characterized isolated from adipose tissue rats. vitro...
Abstract This study indicates the synthesis, cholinesterase (ChE) inhibitory activity, and molecular modeling studies of 48 compounds as o ‐ p ‐(3‐substitutedethoxyphenyl)‐1 H ‐benzimidazole derivatives. According to ChE inhibitor activity results, generally, para series are more active against acetylcholinesterase (AChE) whereas ortho butyrylcholinesterase (BuChE). The most AChE BuChE A12 B14 with IC 50 values 0.14 0.22 μM, respectively. Additionally, 16 AChE/BuChE were chosen investigate...
Purpose: Neuropeptides and neurotrophic factors are thought to be involved in epileptogenesis. This study aims investigate the potential effects of anticonvulsant drugs on neuropeptides (galanin neuropeptide Y) (BDNF NGF) pentylenetetrazol (PTZ)-kindled seizures rat.Methods: Forty-eight adult male Sprague-Dawley rats were included study. The animals divided into 8 groups six rats. Group 1 was defined as naïve control, received no medication. 2 (PTZ + saline) treated with sub-convulsive doses...
Background Gadolinium-based contrast agents (GBCAs) are widely used in magnetic resonance imaging (MRI). Recently, increased signal intensity has been reported specific brain areas after repeated administrations of GBCAs. Purpose To investigate the toxic effects GBCAs on neuronal cells by using SH-SY5Y neuroblastoma cell cultures. Material and Methods For toxicity assays, were incubated with different doses (0–1000 µM) several macrocyclic (gadoterate meglumine gadobutrol) linear...
The medical intervention for autism spectrum disorder (ASD) is restricted to ameliorating comorbid situations. Granulocyte colony-stimulating factor (G-CSF) a growth that enhances the proliferation, differentiation, and survival of hematopoietic progenitor cells. In present study, we aimed investigate effects G-CSF in maternal immune activation-induced model.Sixteen female six male Wistar adult rats were included study. After 21 days, 48 littermates (eight controls, eight 16...
The aim of this research was to determine the anti-inflammatory effect betaine on sepsis-induced acute respiratory distress syndrome (ARDS) in rats through histopathological examination, radiologic imaging, and biochemical analysis. Eight were included control group, no procedure performed. Feces intraperitoneal (FIP) performed 24 create a ARDS model. These separated into three groups as follows: FIP alone (sepsis n=8), + saline (1 mL/kg, placebo (500 mg/kg, n=8). Computed tomography (CT)...