A5068243274- Pneumonia and Respiratory Infections
- Immune Response and Inflammation
- Immune Cell Function and Interaction
- Immune cells in cancer
- Atherosclerosis and Cardiovascular Diseases
- Neonatal Respiratory Health Research
- Inflammatory mediators and NSAID effects
- Immunotherapy and Immune Responses
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Adenosine and Purinergic Signaling
- Pneumocystis jirovecii pneumonia detection and treatment
- Neuroinflammation and Neurodegeneration Mechanisms
- Tuberculosis Research and Epidemiology
- Immune responses and vaccinations
- Viral gastroenteritis research and epidemiology
- Synthesis and Catalytic Reactions
- Antifungal resistance and susceptibility
- Acute Kidney Injury Research
- Ion Transport and Channel Regulation
- Liver physiology and pathology
- Galectins and Cancer Biology
- Immunodeficiency and Autoimmune Disorders
- Chronic Kidney Disease and Diabetes
- Vagus Nerve Stimulation Research
- Helicobacter pylori-related gastroenterology studies
Tanta University
2018-2025
Boston University
2015-2024
Suez Canal University
2024
Pulmonary Associates
2021-2022
Boston Medical Center
2015
Sandwich panels, consisting of two concrete wythes that encase an insulating core, are designed to improve energy efficiency and reduce the weight construction applications. This research examines thermal flexural properties a novel sandwich panel incorporates ultra-high-performance fiber-reinforced (UHPFRC) cellular lightweight (CLC) as its core material. Seven specimens were tested for their thermo-flexural performance using four-point bending tests. The experimental parameters included...
Lung-resident memory B cells (BRM cells) are elicited after influenza infections of mice, but connections to other pathogens and hosts — as well their functional significance have yet be determined. We postulate that BRM core components lung immunity. To test this, we examined whether by the respiratory pathogen pneumococcus, present in humans, important pneumonia defense. Lungs mice had recovered from pneumococcal did not contain organized tertiary lymphoid organs, plasma noncirculating...
Abstract Barrier tissues are populated by functionally plastic CD4 + resident memory T (T RM ) cells. Whether the barrier epithelium regulates cell locations, plasticity and activities remains unclear. Here we report that lung epithelial cells, including distinct surfactant protein C (SPC) low MHC high function as anatomically-segregated temporally-dynamic antigen presenting In vivo ablation of MHC-II results in altered localization Recurrent encounters with cognate absence leads cells to...
Community-acquired pneumonia is a widespread disease with significant morbidity and mortality. Alveolar macrophages are tissue-resident lung cells that play crucial role in innate immunity against bacteria cause pneumonia. We hypothesized alveolar display adaptive characteristics after resolution of bacterial studied mice 1 to 6 months self-limiting infections Streptococcus pneumoniae, the most common macrophages, but not other myeloid cells, recovered from showed long-term modifications...
Oxidative damage to renal tubular epithelial cells is a fundamental pathogenic mechanism implicated in both acute kidney injury and chronic diseases. Because cell survival influences the outcome of diseases, identifying its molecular regulators could provide new insight into pathobiology possible therapeutic strategies for these We have identified transmembrane immunoglobulin domain-containing 1 (TMIGD1) as novel adhesion molecule, which highly conserved humans other species. TMIGD1...
Recovery from pneumococcal pneumonia remodels the pool of alveolar macrophages so that they exhibit new surface marker profiles, transcriptomes, metabolomes, and responses to infection. Mechanisms mediating macrophage phenotypes after have not been delineated. IFN-γ its receptor on were essential for certain, but all, aspects remodeled phenotype. was produced by CD4+ T cells plus other cells, cell depletion did prevent remodeling. In mice infected or recovering pneumococcus, monocytes...
Recovery from respiratory pneumococcal infections generates lung-localized protection against heterotypic bacteria, mediated by resident memory lymphocytes. Optimal in mice requires re-exposure to pneumococcus within days of initial infection. Serial surface marker phenotyping B cell populations a model immunity revealed that bacterial stimulates the immediate accumulation dynamic and heterogeneous cells lung, is essential for establishment lung (BRM) cells. The early wave were activated,...
Ligand stimulation promotes downregulation of RTKs, a mechanism by which through the ubiquitination pathway are removed from cell surface, causing temporary termination RTK signaling. The molecular mechanisms governing trafficking and maturation in endoplasmic reticulum (ER)/Golgi compartments poorly understood. Vascular endothelial growth factor receptor-2 (VEGFR-2) is prototypic that plays critical role physiologic pathologic angiogenesis. Here we demonstrate Ring Finger Protein 121...
Identifying host factors that contribute to pneumonia incidence and severity are of utmost importance guiding the development more effective therapies. Lectin-like oxidized low-density lipoprotein receptor 1 (LOX-1, encoded by OLR1) is a scavenger known promote vascular injury inflammation, but whether how LOX-1 functions in lung unknown. Here, we provide evidence substantial accumulation lungs patients with acute respiratory distress syndrome mice pneumonia. Unlike previously described...
Cyclic di-AMP (c-di-AMP) is an important signaling molecule between and within pneumococci, as a uniquely prokaryotic product it can be recognized by mammalian cells danger signal that triggers innate immunity. Roles of c-di-AMP in directing host responses during pneumococcal infection are only beginning to defined. We hypothesized pneumococci with defective catabolism due phosphodiesterase deletions could illuminate roles mediating infection. Pneumococci deficient 2 (Pde2) stimulated rapid...
Streptococcus pneumoniae is the most common etiology of bacterial pneumonia, one leading causes death in children and elderly worldwide. During non-lethal infections with S. pneumoniae, lymphocytes accumulate lungs protect against reinfection serotype-mismatched strains. Cluster differentiation CD4+ resident memory T (TRM) cells are known to be crucial for this protection, but diversity lung TRM has yet fully delineated. We aimed identify unique subsets their contributions immunity. After...
Abstract Systemic duress, such as that elicited by sepsis, burns, or trauma, predisposes patients to secondary pneumonia, demanding better understanding of host pathways influencing this deleterious connection. These pre-existing circumstances are capable triggering the hepatic acute-phase response (APR), which we previously demonstrated is essential for limiting susceptibility lung infections. To identify potential mechanisms underlying protection afforded lung–liver axis, our studies aimed...
Abstract Recovery from pneumococcal ( Spn ) pneumonia induces development of tissue resident memory CD4 + T RM cells, B and antibody secreting plasma cells in experienced lungs. These lymphocytes confer protection against subsequent lethal challenge by serotype mismatched (termed as heterotypic immunity). While traditional flow cytometry gating strategies support premeditated identification using a limited set markers, discovery novel necessitates stable platforms that can handle larger sets...
Abstract Background The global poultry industry has been experiencing increasing condemnation at slaughterhouses since 2011, due to the emergence of avian reovirus (ARV) variant strains. Recently seven ARV genogroup clusters were identified based on σC sequence S1 segment that was used as a genetic marker characterize and classify ARV. Results Among ninety-seven suspected broilers, breeders, commercial grandparent’s homogenates, PCR confirmed in thirty-five (36%). Samples collected from...
A promising treatment for allergic asthma (AA) in children is the sublingual specific immunotherapy (SLIT) which targets mild or moderate persistent AA types. There have not been any studies to investigate efficacy and safety of adding SLIT combination therapy (budesonide / formoterol) asthmatic sensitive house dust mite (HDM). The aims this current study were evaluate effectiveness HDM with over a three-year period. Another aim was possibility reducing dose on using SLIT. This has followed...