A5077011242- Mitochondrial Function and Pathology
- Photosynthetic Processes and Mechanisms
- Fatty Acid Research and Health
- ATP Synthase and ATPases Research
- Advanced Computational Techniques and Applications
- Microbial Metabolic Engineering and Bioproduction
- Lipid metabolism and biosynthesis
- Liver Disease Diagnosis and Treatment
- Surgical Simulation and Training
- Musculoskeletal pain and rehabilitation
- Oil Spill Detection and Mitigation
- Big Data Technologies and Applications
- Metalloenzymes and iron-sulfur proteins
- Scientific Computing and Data Management
- Muscle activation and electromyography studies
- Cell Image Analysis Techniques
- Data-Driven Disease Surveillance
- Oceanographic and Atmospheric Processes
- Maritime Navigation and Safety
- Environmental Monitoring and Data Management
- Diet and metabolism studies
- Milk Quality and Mastitis in Dairy Cows
- Advanced Breast Cancer Therapies
- Forensic Entomology and Diptera Studies
- Peroxisome Proliferator-Activated Receptors
University Children's Hospital Tübingen
2023
CMCC Foundation - Euro-Mediterranean Center on Climate Change
2015-2017
Istituti di Ricovero e Cura a Carattere Scientifico
2011
University of Salento
2006-2011
Istituto Nazionale di Fisica Nucleare, Sezione di Lecce
2004
We have examined the status of cytochrome bc 1 complex in mitochondrial membranes from yeast mutants which genes for one or more subunits were deleted. When wild‐type resolved by native gel electrophoresis and analyzed immunodecoration, was detected as a mixed population enzymes, consisting dimers, ternary complexes dimers associated with two copies c oxidase complex. deletion analyzed, dimer not many mutant membranes, some contained common set subcomplexes. these subcomplexes fractionated...
The assembly status of the cytochrome bc(1) complex has been analyzed in distinct yeast deletion strains which genes for one or more subunits were deleted. In all tested, a sub-complex approximately 500 kDa was found when mitochondrial membranes by blue native electrophoresis. subsequent molecular characterization this sub-complex, carried out second dimension SDS/PAGE and immunodecoration, revealed presence two catalytic subunits, b c(1), associated with noncatalytic core protein 1, 2,...
The mitochondrial tricarboxylate carrier supplies cytosol with the carbon units necessary for hepatic lipogenesis. activities of cytosolic acetyl-CoA carboxylase and fatty acid synthetase are therefore strictly connected to function carrier. Dietary polyunsaturated acids (PUFA) potent modulators In rats fed a diet enriched 2.5% krill oil (KO), novel source dietary n-3 PUFA, time-dependent decrease in lipogenic enzymes was found. KO induced inhibition lipogenesis more pronounced than that...
The cytochrome bc1 complex of the yeast Saccharomyces cerevisiae is composed 10 different subunits that are assembled as a symmetrical dimer in inner mitochondrial membrane. Three contain redox centers and participate catalysis, whereas little known about function seven supernumerary subunits. To gain further insight into assembly process, we have examined subunit composition membranes isolated from mutants which genes for b were deleted containing double deletions Deletion any one encoding...
Conjugated linoleic acid (CLA) is able to reduce adiposity by affecting lipid metabolism. In particular, CLA administration mice reduces body fat mass with a concomitant accumulation in the liver. We investigated effects of on activity mitochondrial citrate carrier (CIC), which implicated hepatic lipogenesis. The transport CIC, measured both intact mitochondria and proteoliposomes, progressively increased duration feeding. An increase CIC approximately 1.7-fold was found 16 week CLA-treated...
The Rieske iron-sulfur protein, one of the catalytic subunits cytochrome complex, is involved in electron transfer at level inner membrane yeast mitochondria. protein encoded by nuclear DNA and, after being synthesized cytosol, imported into mitochondria with help a cleavable N-terminal presequence. besides incorporating 2Fe-2S cluster, also interacts other and non-catalytic thereby assembling mature functional respiratory complex. In this paper, we summarize most recent findings on import...
Conjugated linoleic acid (CLA) strongly prevents fat accumulation in adipose tissue of mice, even if hepatic deposition and insulin resistance are concomitantly observed. This study investigated the possibility maintaining antiadiposity properties CLA while preventing adverse effects such as liver steatosis hyperinsulinemia. To this end, mice were divided into three groups fed a standard diet (control) or supplemented with 1% mixture plus 7.5% pine nut oil (CLA + P). The combination P...
Abstract. Reliable and timely information on the environmental conditions at sea is key to safety of professional recreational users as well optimal execution their activities. The possibility obtaining in due time with adequate accuracy marine coastal environment defined situational awareness (SSA). Without meteorological oceanographic conditions, have a limited capacity respond, which has led loss lives large disasters enormous consequent damage economy, society ecosystems. Within...
In spatial health research, it is necessary to consider not only the spatial-temporal patterns of diseases, but also external environmental factors, such as effects climate change on air quality, that may influence insurgence or progression diseases (e.g. respiratory and cardiovascular cancer, male human infertility, etc.). this paper, we propose a Spatial Data analysis Infrastructure (SDI) for pathologies related factors and, more specifically, change. The main goal development new...
Phytoplankton is a quality element for determining the ecological status of transitional water ecosystems. In routine analysis, bio-volume and surface area phytoplankton are most studied morphometric descriptors. Bio-volume can be estimated by comparing algae with similar three-dimensional geometric forms their volume, measuring linear dimensions required its calculation images acquired an inverse microscope. Software such as LUCIA-G (Laboratory Imaging) determines, in automatic way, only...
Abstract. An efficient, secure, and interoperable data platform solution has been developed in the TESSA project to provide fast navigation access stored archive, as well a standard-based metadata management support. The mainly targets scientific users Situational Sea Awareness high-level services such Decision Support Systems (DSS). These datasets are accessible through following three main components: Data Access Service (DAS), Metadata Service, Complex Analysis Module (CDAM). DAS allows...
Abstract. An efficient, secure and interoperable data platform solution has been developed in the TESSA project to provide fast navigation access stored archive, as well a standard-based metadata management support. The mainly targets scientific users situational sea awareness high-level services such decision support systems (DSS). These datasets are accessible through following three main components: Data Access Service (DAS), Metadata Complex Analysis Module (CDAM). DAS allows archive by...