A5043656025- Drug Transport and Resistance Mechanisms
- Cancer-related Molecular Pathways
- Nanoparticle-Based Drug Delivery
- Metal complexes synthesis and properties
- Ginger and Zingiberaceae research
- RNA Interference and Gene Delivery
- Lipid Membrane Structure and Behavior
- Berberine and alkaloids research
- Sirtuins and Resveratrol in Medicine
- Bioactive natural compounds
- Extracellular vesicles in disease
- HIV/AIDS drug development and treatment
- Gut microbiota and health
- Tryptophan and brain disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Phytochemical compounds biological activities
- Cancer Research and Treatments
- Synthesis and bioactivity of alkaloids
- Nanoplatforms for cancer theranostics
- Trace Elements in Health
- Ubiquitin and proteasome pathways
- Advancements in Transdermal Drug Delivery
- MicroRNA in disease regulation
- Autophagy in Disease and Therapy
Monash University Malaysia
2021-2024
Australian Regenerative Medicine Institute
2023
Monash University
2023
Taylor's University
2021-2022
Abstract The human gastrointestinal tract is populated with a diverse microbial community. vast genetic and metabolic potential of the gut microbiome underpins its ubiquity in nearly every aspect biology, including health maintenance, development, aging, disease. advent new sequencing technologies culture-independent methods has allowed researchers to move beyond correlative studies toward mechanistic explorations shed light on microbiome–host interactions. Evidence unveiled bidirectional...
Zerumbone (ZER), a potential anticancer agent for breast cancer treatment, has limited clinical applications due to its poor water solubility and targeting ability. The of ZER been partly overcome by loading into nanostructured lipid carriers (ZER-NLC). However, the lack selectivity is still concern in settings. To these limitations, ZER-NLC was co-loaded with an active-targeting known as superparamagnetic iron oxide nanoparticles (SPION) that may direct tumor site external magnetic field....
Copper complex has been gaining much attention in anticancer research as a targeted agent since cancer cells uptake more copper than non-cancerous cells. Our group synthesised ternary complex, which is composed of 1,10-phenanthroline and tyrosine [Cu(phen)(L-tyr)Cl].3H20. These two payloads have designed to cleave DNA inhibit protein degradation system (proteasome) concurrently cells, making this dual-target compound. The current study was carried out investigate the mode cell death role...
Ubiquitin-proteasome system (UPS) and autophagy are interconnected proteolysis pathways implicated in doxorubicin resistance of breast cancer cells. Following anticancer treatments, either plays a cytoprotective role or augments treatment-induced cytotoxicity. However, the cells cotreated with ixazomib remains unclear. The expression proteins (LC3A/B Beclin-1) UPS protein (ubiquitin) MDA-MB-231 MCF-7 following doxorubicin, ixazomib, and/or hydroxychloroquine were determined by western blot....
Background: The lack of specificity, severe side effects, and development drug resistance have largely limited the use platinum-based compounds in cancer treatment. Therefore, copper complexes emerged as potential alternatives to compounds. Objective: Ternary (II) complex incorporated with 1-10-phenanthroline L-tyrosine was investigated for its anti-cancer effects HT-29 colorectal cells. Methods: Cytotoxic ternary cells evaluated using MTT assay, Real-Time Cell Analysis (RTCA) lactate...
Zerumbone (ZER), a potential anticancer agent for breast cancer treatment, has limited clinical applications due to its poor water solubility and targeting ability. The of ZER been partly overcome by loading into nanostructured lipid carriers (ZER-NLC). However, the lack selectivity is still concern in settings. To these limitations, ZER-NLC was co-loaded with an active-targeting known as superparamagnetic iron oxide nanoparticles (SPION) that may direct tumor site external magnetic field....
Background: Dryobalanops rappa is a plant species belonging to the family of Dipterocarpaceae. Nevertheless, active compounds present in D. have never been investigated. Objective: The aim this research isolate and characterize from study its bioactivity against human MCF-7 breast cancer A549 lung cell lines several bacterial strains. Methods: isolation step was carried out using combination chromatographic techniques. structure isolated elucidated mainly NMR spectroscopy. cytotoxic activity...