Background: Coronavirus 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus (SARS-CoV-2), has created a tremendous economic and medical burden. The prevalence prognostic value of SARS-CoV-2-induced kidney impairment remain controversial. current study aimed to provide additional evidence on incidence injury (AKI) in COVID-19 patients propose use urinalysis as tool for screening impairment. Methods: 178 with confirmed were enrolled this retrospective cohort study....

Currently, there is rationale for separating the systemic manifestations of classical inflammation from (SI) itself as an independent form general pathological process underlying pathogenesis most severe acute and chronic diseases. With this aim in view, we used integral scales SI (ChSI), including following blood plasma parameters: interleukins 6, 8, 10; tumor necrosis factor alpha; C-reactive protein; D-dimer; cortisol; troponin I; myoglobin. The presence multiple organ dysfunction...

Chronic hepatitis C virus (HCV) and HIV viral infections are characterized by systemic inflammation. Yet the relative levels, drivers correlates of inflammation in these settings not well defined.Seventy-nine HIV-infected patients who had been receiving antiretroviral therapy (ART) for more than 2 years suppressed plasma levels (< 50 HIV-1 RNA copies/mL) were included study. Two patient groups, HCV-positive/HIV-positive HCV-negative/HIV-positive, a control group comprised healthy volunteers...

We defined Systemic inflammation (SI) as a "typical, multi-syndrome, phase-specific pathological process, developing from systemic damage and characterized by the total inflammatory reactivity of endotheliocytes, plasma blood cell factors, connective tissue and, at final stage, microcirculatory disorders in vital organs tissues." The goal work: to determine methodological approaches particular methodical solutions for problem identification SI common process. can be presence proinflammatory...

The lecture presents modern data on systemic inflammation, as well an original concept of its genesis. This disorder is considered a typical pathological process being fundamental to pathogenesis the most critical states different origin. Distinct features "classical" and inflammation are discussed, whereas underlying immunological pathophysiological mechanisms subject classification. Main constitutive processes, phases certain variants their proceeding characterized well. A definition...

T Cell Immune Regulator 1, ATPase H + Transporting V0 Subunit A3 (TCIRG1 gene provides instructions for making one part, the a3 subunit, of a large protein complex known as vacuolar -ATPase (V-ATPase). V-ATPases are group similar complexes that act pumps to move positively charged hydrogen atoms (protons) across membranes. Single amino acid changes in highly conserved areas TCIRG1 have been linked autosomal recessive osteopetrosis and severe congenital neutropenia. We used multiple...

The mechanisms regulating clonal expansion and contraction of T cells in response to immunization remain be identified. A recent study established that there was a log-linear relation between CD4 T-cell precursor number (PN) factor (FE), with slope ∼-0.5 over range 3-30,000 precursors per mouse. results suggested inhibition either by competition for specific antigen-presenting or the action other antigen-specific same microenvironment as most likely explanation. Several molecular potentially...

The life cycle of human immunodeficiency virus type-1 (HIV-1) makes possible the realization regulatory strategies that can lead to complex dynamical behavior system. We analyze strategy which is based on two feedback mechanisms, one mediating a positive regulation replication by Tat protein via antitermination genomic RNAs transcription TAR (transactivation responsive) element proviral DNA and second mechanism providing negative splicing full-length (9 kb) incompletely spliced (4 their...

HIV infection is multi-faceted and a multi-step process. The virus-induced pathogenic mechanisms are manifold mediated through range of positive negative feedback regulations immune physiological processes engaged in virus-host interactions. fundamental questions towards understanding the pathogenesis now shifting to 'dynamic' categories: (i) why HIV-immune response equilibrium finally disrupted? (ii) can one modify dynamic for host benefit? (iii) predict outcome system perturbation via...

To design an effective and safe vaccine against betacoronaviruses, it is necessary to use their evolutionarily conservative antigenic determinants that will elicit the combination of strong humoral cell-mediated immune responses. Targeting such minimizes risk antibody-dependent enhancement viral infection. This phenomenon was observed in animal trials experimental vaccines SARS-CoV-1 MERS-CoV were developed based on inactivated coronavirus or vector constructs expressing spike protein (S)...

Hennekam syndrome (HS) is an autosomal recessive disease in the pathogenesis of which lymphangiectasia and lymphedema plays a key role. HS associated with mutations CCBE1, FAT4, ADAMTS3 proteins that somehow affect activation primary lymphangiogenic growth factor VEGF-C. We used several silico methods to test this theory. According NCBI, FAT4 gene contains 3,343 non-synonymous SNPs, 298 were predicted be deleterious using SIFT Polyphen2. These SNPs further studied various mutation prediction...

The effects of hepatitis C virus (HCV) coinfection on immune homeostasis and restoration in treated HIV infection are not well understood.We studied 79 HIV-infected patients who had been receiving HAART for more than 2 years viral load below 50 copies/ml. Four patient groups were studied: HIV/HCV, CD4⁺ cells above 350/μl; CD4 350/μl. Controls comprised 20 healthy volunteers. Naive, central memory, effector terminal T enumerated. Naive CD4CD31 counted as recent thymic emigrants (RTEs)....

The scavenger receptors (SRs)) include &gt; 30 different molecules structurally classified into 11 classes (A to L). They are expressed mostly on stromal macrophages, and their expression may be augmented in direct dependence with concentrations of ligands. SRs heterogenous by structure, however, being common functional potential. E.g., SR participate absorption modified low-density lipoproteins glycated proteins, apoptotic ageing cells, altered erythrocytes platelets, like as a big variety...

Plasmacytoid dendritic cell (pDC)-mediated protection against cytopathic virus infection involves various molecular, cellular, tissue-scale, and organism-scale events. In order to better understand such multiscale interactions, we have implemented a systems immunology approach focusing on the analysis of structure, dynamics operating principles virus-host interactions which constrain initial spread pathogen. Using high-resolution experimental data sets coming from well-described mouse...